Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules

2015 ◽  
Vol 12 (5) ◽  
pp. 1391-1401 ◽  
Author(s):  
Madeleine Witting ◽  
Alexander Boreham ◽  
Robert Brodwolf ◽  
Kateřina Vávrová ◽  
Ulrike Alexiev ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Dermal Delivery

scholarly journals Formulation and Characterization of Native and Crosslinked Hyaluronic Acid Microspheres for Dermal Delivery of Sodium Ascorbyl Phosphate: A Comparative Study

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 254 ◽  
Author(s):  
Arianna Fallacara ◽  
Filippo Marchetti ◽  
Michele Pozzoli ◽  
Ugo Raffaello Citernesi ◽  
Stefano Manfredini ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Spherical Shape ◽  
Kinetic Mechanism ◽  
High Yield ◽  
Release Kinetic ◽  
Polymer Swelling ◽  
Dermal Delivery ◽  
Emulsification Solvent Evaporation ◽  
First Time

The present work evaluates for the first time the use of urea-crosslinked hyaluronic acid (HA-CL), a novel derivative of native hyaluronic acid (HA), to produce microspheres (MS) by emulsification-solvent evaporation, for dermal delivery of sodium ascorbyl phosphate (SAP). As the term of comparison, HA MS were prepared. A pre-formulation study—investigation of the effects of polymers solutions properties (pH, viscosity) and working conditions—led to the - production of optimized HA-CL MS and HA-CL—SAP MS with: almost unimodal size distributions; mean diameter of 13.0 ± 0.7 and 9.9 ± 0.8 µm, respectively; spherical shape and rough surface; high yield, similar to HA MS and HA–SAP MS (≈ 85%). SAP was more efficiently encapsulated into HA-CL MS (78.8 ± 2.6%) compared to HA MS (69.7 ± 4.6%). Physical state, thermal properties, relative moisture stability of HA-CL MS and HA-CL–SAP MS were comparable to those of HA MS and HA–SAP MS. However, HA-CL–SAP MS exhibited an extended drug release compared to HA–SAP MS, despite the same kinetic mechanism—contemporaneous drug diffusion and polymer swelling/dissolution. Therefore, HA-CL formulation showed a greater potential as microcarrier (for encapsulation efficiency and release kinetic), that could be improved, in future, using suitable excipients.

Improving dermal delivery of hyaluronic acid by ionic liquids for attenuating skin dehydration

2020 ◽  
Vol 150 ◽  
pp. 528-535 ◽  
Author(s):  
Xiying Wu ◽  
Hongmin Zhang ◽  
Shuhua He ◽  
Qin Yu ◽  
Yi Lu ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Hyaluronic Acid ◽  
Dermal Delivery

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

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