scholarly journals Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles

2013 ◽  
pp. 3437 ◽  
Author(s):  
Yang Guo ◽  
Zhuoli Zhang ◽  
Weiguo Li ◽  
Nicolai ◽  
Procissi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Shell Nanoparticles ◽  
Gold Shell ◽  
Pancreatic Cancer Cells ◽  
Photothermal Ablation ◽  
Iron Oxide Core

Multifunctionalized iron oxide nanoparticles for selective targeting of pancreatic cancer cells

2017 ◽  
Vol 1861 (6) ◽  
pp. 1597-1605 ◽  
Author(s):  
Sara Trabulo ◽  
Antonio Aires ◽  
Alexandra Aicher ◽  
Christopher Heeschen ◽  
Aitziber L. Cortajarena
Keyword(s):  
Pancreatic Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Pancreatic Cancer Cells ◽  
Selective Targeting

scholarly journals The Effect of Superparamagnetic Iron Oxide with iRGD Peptide on the Labeling of Pancreatic Cancer CellsIn Vitro: A Preliminary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hou Dong Zuo ◽  
Wei Wu Yao ◽  
Tian Wu Chen ◽  
Jiang Zhu ◽  
Juan Juan Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Tumor Therapy ◽  
Superparamagnetic Iron Oxide ◽  
Cell Labeling ◽  
Pancreatic Cancer Cells ◽  
Good Biocompatibility ◽  
Tumor Homing ◽  
The Many

The iRGD peptide loaded with iron oxide nanoparticles for tumor targeting and tissue penetration was developed for targeted tumor therapy and ultrasensitive MR imaging. Binding of iRGD, a tumor homing peptide, is mediated by integrins, which are widely expressed on the surface of cells. Several types of small molecular drugs and nanoparticles can be transfected into cells with the help of iRGD peptide. Thus, we postulate that SPIO nanoparticles, which have good biocompatibility, can also be transfected into cells using iRGD. Despite the many kinds of cell labeling studies that have been performed with SPIO nanoparticles and RGD peptide or its analogues, only a few have applied SPIO nanoparticles with iRGD peptide in pancreatic cancer cells. This paper reports our preliminary findings regarding the effect of iRGD peptide (CRGDK/RGPD/EC) combined with SPIO on the labeling of pancreatic cancer cells. The results suggest that SPIO with iRGD peptide can enhance the positive labeling rate of cells and the uptake of SPIO. Optimal functionalization was achieved with the appropriate concentration or concentration range of SPIO and iRGD peptide. This study describes a simple and economical protocol to label panc-1 cells using SPIO in combination with iRGD peptide and may provide a useful method to improve the sensitivity of pancreatic cancer imaging.

Targeting pancreatic cancer cells in vitro with super-paramagnetic iron oxide nanoparticles

Pancreatology ◽  
2012 ◽  
Vol 12 (6) ◽  
pp. 548
Author(s):  
P. Sykes ◽  
C. Olariu ◽  
E. Hasan ◽  
D. Lydon ◽  
E. Costello ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Super Paramagnetic Iron Oxide ◽  
Pancreatic Cancer Cells
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