scholarly journals Application of liposomal technologies for delivery of platinum analogs in oncology

2013 ◽  
pp. 3309 ◽  
Author(s):  
Andrew Wang ◽  
Wenbin Lin ◽  
Demin Liu ◽  
Chunbai He
Keyword(s):  
Platinum Analogs

scholarly journals Molecular Mechanisms and Immunomodulatory Effects of Platinum Analogs on Some Genes and as Anticancer Drugs: Review Article

2020 ◽  
Vol 7 (2) ◽  
pp. 20-26
Author(s):  
Dalia A. Shakur ◽  
Suhad F. H. Al-Mugdadi ◽  
Inam S. Arif
Keyword(s):  
Cytotoxic Effect ◽  
Molecular Mechanisms ◽  
Review Article ◽  
Chemotherapeutic Drug ◽  
Immunomodulatory Effects ◽  
Molecular Mechanism Of Action ◽  
Immunomodulatory Properties ◽  
Dna Break ◽  
Dna Purine Bases ◽  
Platinum Analogs

Platinum analogs includes cisplatin, oxaliplatin and carboplatin. Cisplatin is a chemotherapeutic drug with excellent success in the management of human malignancies. Molecular mechanism of action related to its capacity to crosslink of DNA purine bases; also, by interfere with DNA repair, leading to DNA break, and consequently lead to apoptosis in cancer cells. Cisplatin also found to have immunomodulatory properties besides its cytotoxic effect.

Studies on mutagenesis and repair induced by platinum analogs

1986 ◽  
Vol 173 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Robert J. Fram ◽  
Paul S. Cusick ◽  
M.G. Marinus
Keyword(s):  
Platinum Analogs

Platinum Analogs

2013 ◽  
pp. 630-630
Author(s):  
Larry C. Daugherty ◽  
Brandon J. Fisher ◽  
Christin A. Knowlton ◽  
Michelle Kolton Mackay ◽  
David E. Wazer ◽  
...  
Keyword(s):  
Platinum Analogs

TOXIC SIDE EFFECTS OF PLATINUM ANALOGS

Cisplatin ◽  
1980 ◽  
pp. 227-236 ◽  
Author(s):  
John E. Schurig ◽  
William T. Bradner ◽  
James B. Huftalen ◽  
Gary J. Doyle ◽  
Jonas A. Gylys
Keyword(s):  
Side Effects ◽  
Platinum Analogs

scholarly journals A PROSPECTIVE STUDY OF ADVERSE DRUG REACTIONS DUE TO PLATINUM ANALOGS - CHEMOTHERAPY IN A TERTIARY CARE HOSPITAL

2018 ◽  
Vol 11 (6) ◽  
pp. 215
Author(s):  
Sumit Kumar ◽  
Badruddeen Badruddeen ◽  
Singh S P ◽  
Mohammad Irfan Khan
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
World Health ◽  
Care Hospital ◽  
Drug Reactions ◽  
Medical College ◽  
Health Organization ◽  
A Prospective Study ◽  
Platinum Analogs

Objective: The objective of this study was to analyze the types of adverse drug reactions (ADRs) associated with platinum analogs (cisplatin, carboplatin and oxaliplatin) used for cancer chemotherapy in a tertiary care hospital and determine their causal relationship with the offending drug.Methods: This prospective, observational, non-interventional study was conducted in a tertiary care hospital at GSVM Medical College Kanpur, India, for 4 months. Patients of all age and either sex were included in the study. ADRs were reported by the physicians of oncology department of the hospital and ADRs were assessed for different parameters -causality, outcome, and seriousness of ADR as per the World Health Organization (WHO), type of ADRs as per expanded Rawlins and Thompson’s classification, predictability using council for international organization of medical sciences guidelines and severity using modified Hartwig’s scale. Descriptive statistics were used for data analysis.Results: A total of 140 ADRs were reported from platinum analogs following treatment of different types of cancer in hospital. The burden of ADRs in each patient was 2.41. Most of the ADRs were observed in the age group of 40–60 years. Vomiting (27 ADRs) was commonly reported reaction. Among platinum analogs, cisplatin leads to 82 ADRs (58.57%) followed by carboplatin with 53 ADRs (37.86%) and least with oxaliplatin 5 ADRs (3.57%). Most of the ADRs on causality assessment were possible (104, 74.29%) and probable (36, 25.71%) in nature. Type -A ADRs account for 4/5th of the total reported ADRs, followed by Type-B and C. Severity of 90.71% ADRs was found to be mild followed by moderate, with no case of severe and serious nature. Nearly, most of the ADRs were of predictable type (97.14%).Conclusion: The potential of platinum analogs to cause ADRs is high; thus, the need of effective ADRs monitoring is highly emphasized.

Platinum analogs as potential new drugs for bladder cancer

Urology ◽  
1984 ◽  
Vol 23 (3) ◽  
pp. 54-60 ◽  
Author(s):  
Patrick J. Creaven
Keyword(s):  
Bladder Cancer ◽  
New Drugs ◽  
Platinum Analogs
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