scholarly journals 3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair

2021 ◽  
Vol Volume 16 ◽  
pp. 8417-8432
Author(s):  
Chun Liu ◽  
Wen Qin ◽  
Yan Wang ◽  
Jiayi Ma ◽  
Jun Liu ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Sodium Alginate ◽  
Tissue Repair ◽  
Alginate Hydrogel ◽  
Hydrogel Scaffolds ◽  
3D Printed

scholarly journals Drug-Loadable Calcium Alginate Hydrogel System for Use in Oral Bone Tissue Repair

2017 ◽  
Vol 18 (5) ◽  
pp. 989 ◽  
Author(s):  
Luyuan Chen ◽  
Renze Shen ◽  
Satoshi Komasa ◽  
Yanxiang Xue ◽  
Bingyu Jin ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Calcium Alginate ◽  
Tissue Repair ◽  
Alginate Hydrogel ◽  
Calcium Alginate Hydrogel ◽  
Hydrogel System

scholarly journals Printability of 3D Printed Hydrogel Scaffolds: Influence of Hydrogel Composition and Printing Parameters

2019 ◽  
Vol 10 (1) ◽  
pp. 292 ◽  
Author(s):  
Saman Naghieh ◽  
MD Sarker ◽  
N. K. Sharma ◽  
Zohra Barhoumi ◽  
Xiongbiao Chen
Keyword(s):  
Flow Behavior ◽  
Three Dimensional ◽  
Methyl Cellulose ◽  
Alginate Hydrogel ◽  
Hydrogel Scaffolds ◽  
Number Of Factors ◽  
3D Printed ◽  
The Difference ◽  
Printing Processes ◽  
Printing Parameters

Extrusion-based bioprinting of hydrogel scaffolds is challenging due to printing-related issues, such as the lack of capability to precisely print or deposit hydrogels onto three-dimensional (3D) scaffolds as designed. Printability is an index to measure the difference between the designed and fabricated scaffold in the printing process, which, however, is still under-explored. While studies have been reported on printing hydrogel scaffolds from one or more hydrogels, there is limited knowledge on the printability of hydrogels and their printing processes. This paper presented our study on the printability of 3D printed hydrogel scaffolds, with a focus on identifying the influence of hydrogel composition and printing parameters/conditions on printability. Using the hydrogels synthesized from pure alginate or alginate with gelatin and methyl-cellulose, we examined their flow behavior and mechanical properties, as well as their influence on printability. To characterize the printability, we examined the pore size, strand diameter, and other dimensions of the printed scaffolds. We then evaluated the printability in terms of pore/strand/angular/printability and irregularity. Our results revealed that the printability could be affected by a number of factors and among them, the most important were those related to the hydrogel composition and printing parameters. This study also presented a framework to evaluate alginate hydrogel printability in a systematic manner, which can be adopted and used in the studies of other hydrogels for bioprinting.

scholarly journals Lotus seedpod-inspired internal vascularized 3D printed scaffold for bone tissue repair

2021 ◽  
Vol 6 (6) ◽  
pp. 1639-1652
Author(s):  
Xiaoyu Han ◽  
Mingjie Sun ◽  
Bo Chen ◽  
Qimanguli Saiding ◽  
Junyue Zhang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Repair ◽  
3D Printed ◽  
Lotus Seedpod

scholarly journals Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration

2021 ◽  
Vol 22 (12) ◽  
pp. 6203
Author(s):  
Elham Pishavar ◽  
Hongrong Luo ◽  
Mahshid Naserifar ◽  
Maryam Hashemi ◽  
Shirin Toosi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Repair ◽  
Recent Progress ◽  
Human Mesenchymal Stem Cells ◽  
Synthetic Polymers ◽  
Hydrogel Scaffolds ◽  
Concise Review ◽  
Free Treatment

Hydrogels are known as water-swollen networks formed from naturally derived or synthetic polymers. They have a high potential for medical applications and play a crucial role in tissue repair and remodeling. MSC-derived exosomes are considered to be new entities for cell-free treatment in different human diseases. Recent progress in cell-free bone tissue engineering via combining exosomes obtained from human mesenchymal stem cells (MSCs) with hydrogel scaffolds has resulted in improvement of the methodologies in bone tissue engineering. Our research has been actively focused on application of biotechnological methods for improving osteogenesis and bone healing. The following text presents a concise review of the methodologies of fabrication and preparation of hydrogels that includes the exosome loading properties of hydrogels for bone regenerative applications.

scholarly journals Stimuli-responsive supramolecules for bone tissue engineering

2020 ◽  
Vol 10 (2) ◽  
pp. 5122-5127
Keyword(s):  
Tissue Engineering ◽  
Ionic Strength ◽  
Regenerative Medicine ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Repair ◽  
3D Bioprinting ◽  
Stimuli Responsive ◽  
Hydrogel Scaffolds ◽  
Physical Stimuli

In the recent scenario Stimuli responsive supramolecules are used for bone tissue engineering. Stimuli responsive Supramolecules are responding towards the desired stimuli. This has a property to change their dynamics and undergo impulsive and continual assembly or disassembly processes under specific conditions. These supramolecules respond towards chemical and physical stimuli which include: pH, temperature, light, ionic strength, magnetic and electric field sensitive. Stimuli responsive supramolecules are used to various preparations such as hydrogels, scaffolds, hydrogel scaffolds, 3D bioprinting, 4D bioprinting, nanogels and microgels used for the bone tissue repair and regenerative medicine. Manuscript deals with various approaches used to prepare stimuli responsive supramolecules for bone engineering applications.

Bone tissue engineering in the greater omentum with computer-aided design/computer-aided manufacturing scaffolds is enhanced by a periosteum transplant

2020 ◽  
Author(s):  
Hendrik Naujokat ◽  
Klaas Loger ◽  
Juliane Schulz ◽  
Yahya Açil ◽  
Jörg Wiltfang
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Computer Aided Design ◽  
Bone Tissue Regeneration ◽  
Histological Evaluation ◽  
Greater Omentum ◽  
Collagen Membrane ◽  
Computer Aided ◽  
3D Printed ◽  
The Impact

Aim: This study aimed to evaluate two different vascularized bone flap scaffolds and the impact of two barrier membranes for the reconstruction of critical-size bone defects. Materials & methods: 3D-printed scaffolds of biodegradable calcium phosphate and bioinert titanium were loaded with rhBMP-2 bone marrow aspirate, wrapped by a collagen membrane or a periosteum transplant and implanted into the greater omentum of miniature pigs. Results: Histological evaluation demonstrated significant bone formation within the first 8 weeks in both scaffolds. The periosteum transplant led to enhanced bone formation and a homogenous distribution in the scaffolds. The omentum tissue grew out a robust vascular supply. Conclusion: Endocultivation using 3D-printed scaffolds in the greater omentum is a very promising approach in defect-specific bone tissue regeneration.

scholarly journals Therapeutic Effects of the Addition of Fibroblast Growth Factor-2 to Biodegradable Gelatin/Magnesium-Doped Calcium Silicate Hybrid 3D-Printed Scaffold with Enhanced Osteogenic Capabilities for Critical Bone Defect Restoration

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 712
Author(s):  
Wei-Yun Lai ◽  
Yen-Jen Chen ◽  
Alvin Kai-Xing Lee ◽  
Yen-Hong Lin ◽  
Yu-Wei Liu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Silicate ◽  
Clinical Applications ◽  
Fibroblast Growth Factor 2 ◽  
Therapeutic Effects ◽  
Fibroblast Growth ◽  
3D Printed

Worldwide, the number of bone fractures due to traumatic and accidental injuries is increasing exponentially. In fact, repairing critical large bone defects remains challenging due to a high risk of delayed union or even nonunion. Among the many bioceramics available for clinical use, calcium silicate-based (CS) bioceramics have gained popularity due to their good bioactivity and ability to stimulate cell behavior. In order to improve the shortcomings of 3D-printed ceramic scaffolds, which do not easily carry growth factors and do not provide good tissue regeneration effects, the aim of this study was to use a gelatin-coated 3D-printed magnesium-doped calcium silicate (MgCS) scaffold with genipin cross-linking for regulating degradation, improving mechanical properties, and enhancing osteogenesis behavior. In addition, we consider the effects of fibroblast growth factor-2 (FGF-2) loaded into an MgCS scaffold with and without gelatin coating. Furthermore, we cultured the human Wharton jelly-derived mesenchymal stem cells (WJMSC) on the scaffolds and observed the biocompatibility, alkaline phosphatase activity, and osteogenic-related markers. Finally, the in vivo performance was assessed using micro-CT and histological data that revealed that the hybrid bioscaffolds were able to further achieve more effective bone tissue regeneration than has been the case in the past. The above results demonstrated that this type of processing had great potential for future clinical applications and studies and can be used as a potential alternative for future bone tissue engineering research, as well as having good potential for clinical applications.

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

2021 ◽  
pp. 2000398
Author(s):  
Fei Liu ◽  
Wenyu Li ◽  
Hongting Liu ◽  
Teng Yuan ◽  
Yu Yang ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Double Network ◽  
Hydrogel Scaffolds ◽  
3D Printed
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