scholarly journals Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma

2021 ◽  
Vol Volume 16 ◽  
pp. 8433-8446
Author(s):  
Lingling Wu ◽  
Qin Li ◽  
Junjie Deng ◽  
Jinglan Shen ◽  
Weide Xu ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Hybrid ◽  
Hybrid Membrane ◽  
Therapy Efficacy

Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy

2020 ◽  
Vol 12 (37) ◽  
pp. 41138-41147
Author(s):  
Dongdong Wang ◽  
Conghui Liu ◽  
Shiquan You ◽  
Kai Zhang ◽  
Meng Li ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Immune Activation ◽  
Cell Hybrid ◽  
Photothermal Therapy ◽  
Hybrid Membrane ◽  
Coated Nanoparticles

scholarly journals The 'Holy Grail' in Immuno-Oncology: AC BioScience SA is Aiming to Potentiate Anti-PD-1 Therapy Efficacy through Tumor Cell Conditioning Strategy

2020 ◽  
Vol 74 (10) ◽  
pp. 771-775
Author(s):  
Andreas Schläpfer ◽  
Christian Auclair ◽  
Bassam Janji ◽  
Manale Karam ◽  
Muhammad Zaeem Noman
Keyword(s):  
Clinical Trials ◽  
Tumor Cell ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Leading Edge ◽  
Vascular Normalization ◽  
Drug Candidates ◽  
Therapy Efficacy ◽  
Immune Oncology

AC BioScience is a Swiss biotech company based at the EPFL Innovation Park and Biopôle, dedicated to developing groundbreaking therapies to fight a range of cancers and infectious diseases. We are about to start clinical trials with two of four leading-edge cancer drugs mainly focusing on immune-oncology and tumor vascular normalization with multi-billion $ sales potential. Here, we present our strategy and one of our pioneering drug candidates that has already shown exceptional results with tumor cell conditioning to improve the efficacy of immune checkpoint inhibitors.

scholarly journals The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1974
Author(s):  
Wen Yin ◽  
Tianqi Xu ◽  
Mohamed Altai ◽  
Maryam Orougeni ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Targeted Delivery ◽  
Binding Domain ◽  
Albumin Binding ◽  
Tumor Cell Proliferation ◽  
Drug Conjugate ◽  
Therapy Efficacy

Human epidermal growth factor receptor 2 (HER2) is a clinically validated target for breast cancer therapy. Previously, a drug-fused HER2-targeting affinity protein construct successfully extended the survival of mice bearing HER2-expressing xenografts. The aim of this study was to evaluate the influence of the number and positioning of the protein domains in the drug conjugate. Seven HER2-targeting affibody-based constructs, including one or two affibody molecules (Z) with or without an albumin-binding domain (ABD), namely Z, Z-ABD, ABD-Z, Z-Z, Z-Z-ABD, Z-ABD-Z, and ABD-Z-Z, were evaluated on their effects on cell growth, in vivo targeting, and biodistribution. The biodistribution study demonstrated that the monomeric constructs had longer blood retention and lower hepatic uptake than the dimeric ones. A dimeric construct, specifically ABD-Z-Z, could stimulate the proliferation of HER2 expressing SKOV-3 cells in vitro and the growth of tumors in vivo, whereas the monomeric construct Z-ABD could not. These two constructs demonstrated a therapeutic effect when coupled to mcDM1; however, the effect was more pronounced for the non-stimulating Z-ABD. The median survival of the mice treated with Z-ABD-mcDM1 was 63 days compared to the 37 days for those treated with ABD-Z-Z-mcDM1 or for the control animals. Domain permutation of an ABD-fused HER2-targeting affibody-based drug conjugate significantly influences tumor cell proliferation and therapy efficacy. The monomeric conjugate Z-ABD is the most promising format for targeted delivery of the cytotoxic drug DM1.

Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors

Biomaterials ◽  
2019 ◽  
Vol 192 ◽  
pp. 292-308 ◽  
Author(s):  
Qin Jiang ◽  
Yao Liu ◽  
Ranran Guo ◽  
Xianxian Yao ◽  
Seunghyun Sung ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Hybrid Membrane ◽  
Therapy Efficacy ◽  
Melanin Nanoparticles

Cancer–leukocyte hybrid membrane-cloaked magnetic beads for the ultrasensitive isolation, purification, and non-destructive release of circulating tumor cells

Nanoscale ◽  
2020 ◽  
Vol 12 (37) ◽  
pp. 19121-19128
Author(s):  
Zhi-min Chang ◽  
Rui Zhang ◽  
Chao Yang ◽  
Dan Shao ◽  
Yuguo Tang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Tumor Cell ◽  
Cell Adhesion Molecules ◽  
Magnetic Beads ◽  
Circulating Tumor Cell ◽  
Hybrid Membrane ◽  
Immunomagnetic Beads ◽  
Isolation Techniques ◽  
Non Destructive

Most of the current circulating tumor cell (CTC) isolation techniques are based on immunomagnetic beads with antibodies or aptamers that specifically target epithelial cell adhesion molecules (EpCAMs).

HER-2/neu tolerant and non-tolerant mice for fine assessment of antimetastatic potency of dendritic cell-tumor cell hybrid vaccines

Vaccine ◽  
2011 ◽  
Vol 29 (29-30) ◽  
pp. 4690-4697 ◽  
Author(s):  
Lorena Landuzzi ◽  
Agnese Antognoli ◽  
Giordano Nicoletti ◽  
Stefania Croci ◽  
Arianna Palladini ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Tumor Cell ◽  
Cell Hybrid ◽  
Cell Tumor ◽  
Her 2

Dendritic cell?tumor cell hybrid vaccination for metastatic cancer

2004 ◽  
Vol 53 (12) ◽  
pp. 1111-1118 ◽  
Author(s):  
Jose Alexandre M. Barbuto ◽  
Luis F. C. Ensina ◽  
Andreia R. Neves ◽  
Patr�cia C. Bergami-Santos ◽  
Katia R. M. Leite ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Tumor Cell ◽  
Cell Hybrid ◽  
Metastatic Cancer ◽  
Cell Tumor

Evaluation of Dendritic Cell–Tumor Cell Hybrid Vaccine Storage

2008 ◽  
Vol 6 (4) ◽  
pp. 285-288
Author(s):  
Juliana Moreira de Sousa-Canavez ◽  
Dewton de Moraes-Vasconcelos ◽  
Elaine Cristina Corneta ◽  
Katia R.M. Leite ◽  
Luiz H. Camara-Lopes
Keyword(s):  
Dendritic Cell ◽  
Tumor Cell ◽  
Cell Hybrid ◽  
Cell Tumor
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