scholarly journals Targeting Antibacterial Effect and Promoting of Skin Wound Healing After Infected with Methicillin-Resistant Staphylococcus aureus for the Novel Polyvinyl Alcohol Nanoparticles

2021 ◽  
Vol Volume 16 ◽  
pp. 4031-4044
Author(s):  
Dengyan Wu ◽  
Dong Wei ◽  
Maotao Du ◽  
Song Ming ◽  
Qian Ding ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibacterial Effect ◽  
Skin Wound ◽  
The Novel ◽  
Skin Wound Healing ◽  
Methicillin Resistant

scholarly journals Antibacterial Alkaloids from Chelidonium Majus Linn (Papaveraceae) Against Clinical Isolates of Methicillin-Resistant Staphylococcus Aureus

2009 ◽  
Vol 11 (4) ◽  
pp. 90 ◽  
Author(s):  
Guo Ying Zuo ◽  
Fan Yan Meng ◽  
Xiao Yan Hao ◽  
Yun Ling Zhang ◽  
Gen Chun Wang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Agents ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibacterial Effect ◽  
Dilution Method ◽  
Chelidonium Majus ◽  
Methicillin Resistant ◽  
Aerial Parts ◽  
Bioassay Guided Fractionation ◽  
Mrsa Strains

Purpose. This study describes the antibacterial effect of extracts and compounds isolated from the aerial part of Chelidonium majus Linn. (Papaveraceae) acting against clinical strains of methicillin-resistant Staphylococcus aureus (MRSA). Methods. The activities were evaluated by using the macrobroth dilution method and reported as the MICs/MBCs. Results. Bioassay-guided fractionation of the most active extract from the aerial parts (EtOAc) led to the isolation of benzo[c]phenanthridine-type alkaloids 8-hydroxydihydrosanguinarine (hhS), 8-hydroxydihydrochelerythrine (hhC), which were potently active against MRSA strains. Conclusions. The selective antibacterial activity reported in this paper for 8-hydroxylated benzo[c]phenanthridine-type alkaloids isolated from C.majus opens the possibility that they could be helpful for the developing of new antibacterial agents for treating the infection of MRSA which has created nosocomial problem worldwide.

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