scholarly journals The bactericidal effect of liposomal vancomycin as a topical combating system against Methicillin-resistant Staphylococcus aureus skin wound infection in mice

2019 ◽  
Author(s):  
Fahimeh Hajiahmadi ◽  
Mohammad Yousef Alikhani ◽  
Hanifeh Shariatifar ◽  
Mohammad Reza Arabestani ◽  
Davoud Ahmadvand
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bactericidal Effect ◽  
Skin Wound ◽  
Methicillin Resistant

Silver Nanoparticles Toxicity and Bactericidal Effect Against Methicillin-Resistant Staphylococcus aureus: Nanoscale Does Matter

2009 ◽  
Vol 5 (1-4) ◽  
pp. 2-9 ◽  
Author(s):  
Nilda Vanesa Ayala-Núñez ◽  
Humberto H. Lara Villegas ◽  
Liliana del Carmen Ixtepan Turrent ◽  
Cristina Rodríguez Padilla
Keyword(s):  
Staphylococcus Aureus ◽  
Silver Nanoparticles ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bactericidal Effect ◽  
Methicillin Resistant ◽  
Nanoparticles Toxicity

scholarly journals Inflammatory and Antimicrobial Responses to Methicillin-Resistant Staphylococcus aureus in an In Vitro Wound Infection Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82800 ◽  
Author(s):  
Elisabeth M. Haisma ◽  
Marion H. Rietveld ◽  
Anna de Breij ◽  
Jaap T. van Dissel ◽  
Abdoelwaheb El Ghalbzouri ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Infection Model ◽  
Methicillin Resistant

scholarly journals Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers.

2007 ◽  
Vol 54 (3) ◽  
pp. 665-670 ◽  
Author(s):  
Mariusz Grinholc ◽  
Bozena Szramka ◽  
Katarzyna Olender ◽  
Alfreda Graczyk
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bactericidal Effect ◽  
Aureus Strain ◽  
Methicillin Resistant ◽  
Essential Change ◽  
Log10 Unit ◽  
Porphyrin Photosensitizers ◽  
Unit Reduction

Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wavelength. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin diarginate) induced a 3 log10-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log10-unit reduction was obtained. The sensitizers tested executed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.

scholarly journals Correlation between the Bacteriostatic and Bactericide Effect with Antibiofilm and Anticolony Spreading from Javanese Citronella Oil on Methicillin-Resistant Staphylococcus aureus (MRSA)

2019 ◽  
Vol 55 (1) ◽  
pp. 1
Author(s):  
Amaliyah Nurul Hidayah ◽  
Eddy Bagus Wasito ◽  
Kartuti Debora ◽  
Achmad Basori ◽  
Isnaeni Isnaeni ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Biofilm Formation ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Bactericidal Effect ◽  
Methicillin Resistant ◽  
Citronella Oil ◽  
Bactericidal Effects ◽  
Effect Test

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that has been resistant to various types of antibiotics, so it is not easy to be treated with antibiotics and needs other solutions. Javanese citronella oil distilled from the Cymbopogon nardus plant is proven to function as an antibacterial agent (bacteriostatic and bactericidal), fungicide and repellent. This study aimed to prove that there is a positive correlation between bacteriostatic and bactericidal effects with antibiofilm and anticolony spreading from Javanese citronella oil on MRSA. The intended antibiofilm is a barrier to biofilm formation and eradication. Bacteriostatic and antibiofilm effects were tested using microtiter plates assay, bactericidal effect test with subculture into the media and anticolony spreading effect test with spot inoculation in Tryptic Soy Broth media supplemented with 0.24% agar. The bacteriostatic effect test data were analyzed using paired t-test, bactericidal effect using the Friedman test, antibiofilm effect test using Kruskall-Wallis and the results of all the tests correlated using Pearson and Spearman correlation. The statistical significance used was p<0.05. The results showed that Javanese citronella oil had a bacteriostatic concentration of 0.02% (v/v) and bactericidal concentration of 0.78% (v/v). The Pearson correlation test showed that there was a negative correlation between bacteriostatic and bactericidal effects on biofilm formation with r=-0.956 (p=0.000), but the correlation was positive for biofilm eradication with r=0.918 (p=0.000) and anticolony spreading with r=1.000 (p=0.000).

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