scholarly journals Enhancing cellular uptake of activable cell-penetrating peptide–doxorubicin conjugate by enzymatic cleavage

2012 ◽  
pp. 1613 ◽  
Author(s):  
Xian-Rong Qi ◽  
Shi ◽  
Gao ◽  
Xiang
Keyword(s):  
Cellular Uptake ◽  
Cell Penetrating Peptide ◽  
Enzymatic Cleavage ◽  
Cell Penetrating

scholarly journals A comparison of acyl-moieties for noncovalent functionalization of PLGA and PEG-PLGA nanoparticles with a cell-penetrating peptide

RSC Advances ◽  
2021 ◽  
Vol 11 (57) ◽  
pp. 36116-36124
Author(s):  
Omar Paulino da Silva Filho ◽  
Muhanad Ali ◽  
Rike Nabbefeld ◽  
Daniel Primavessy ◽  
Petra H. Bovee-Geurts ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Plga Nanoparticles ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Noncovalent Functionalization ◽  
Cell Penetrating ◽  
A Cell

Noncovalent functionalization with acylated cell-penetrating peptides achieves an efficient cellular uptake of PLGA and PEG-PLGA nanoparticles.

Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems

Synlett ◽  
2017 ◽  
Vol 28 (15) ◽  
pp. 1897-1900
Author(s):  
Zi-Gang Li ◽  
Yan-Hong Jiang ◽  
Hui Zhao ◽  
Yuan Tian
Keyword(s):  
Cellular Uptake ◽  
Biological Research ◽  
Cell Penetrating Peptide ◽  
Peptide Conjugates ◽  
Cellular Toxicity ◽  
Wide Range ◽  
Cell Penetrating ◽  
Effective Delivery ◽  
Cellular Permeability ◽  
Small Molecule Therapeutics

A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is simple, efficient, has minimal cellular toxicity, and might be useful in a wide range of biological research.

The influence of cell penetrating peptide branching on cellular uptake of QDs

2016 ◽  
Author(s):  
Joyce Breger ◽  
James Delehanty ◽  
Kimihiro Susumu ◽  
George Anderson ◽  
Markus Muttenhaler ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals On the mechanisms of the internalization of S413-PV cell-penetrating peptide

2005 ◽  
Vol 390 (2) ◽  
pp. 603-612 ◽  
Author(s):  
Miguel Mano ◽  
Cristina Teodósio ◽  
Artur Paiva ◽  
Sérgio Simões ◽  
Maria C. Pedroso de Lima
Keyword(s):  
Cellular Uptake ◽  
Cell Membranes ◽  
Heparan Sulphate ◽  
Cell Penetrating Peptides ◽  
Membrane Receptors ◽  
Live Cells ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Pv Cell

Cell-penetrating peptides have been shown to translocate across eukaryotic cell membranes through a temperature-insensitive and energy-independent mechanism that does not involve membrane receptors or transporters. Although cell-penetrating peptides have been successfully used to mediate the intracellular delivery of a wide variety of molecules of pharmacological interest both in vitro and in vivo, the mechanisms by which cellular uptake occurs remain unclear. In the face of recent reports demonstrating that uptake of cell-penetrating peptides occurs through previously described endocytic pathways, or is a consequence of fixation artifacts, we conducted a critical re-evaluation of the mechanism responsible for the cellular uptake of the S413-PV karyophilic cell-penetrating peptide. We report that the S413-PV peptide is able to accumulate inside live cells very efficiently through a rapid, dose-dependent and non-toxic process, providing clear evidence that the cellular uptake of this peptide cannot be attributed to fixation artifacts. Comparative analysis of peptide uptake into mutant cells lacking heparan sulphate proteoglycans demonstrates that their presence at the cell surface facilitates the cellular uptake of the S413-PV peptide, particularly at low peptide concentrations. Most importantly, our results clearly demonstrate that, in addition to endocytosis, which is only evident at low peptide concentrations, the efficient cellular uptake of the S413-PV cell-penetrating peptide occurs mainly through an alternative, non-endocytic mechanism, most likely involving direct penetration across cell membranes.

Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

2021 ◽  
Author(s):  
Anselm F. L. Schneider ◽  
Marina Kithil ◽  
M. Cristina Cardoso ◽  
Martin Lehmann ◽  
Christian P. R. Hackenberger
Keyword(s):  
Cell Surface ◽  
Cellular Uptake ◽  
Cell Penetrating Peptide ◽  
Reactive Cell ◽  
Cell Penetrating
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