scholarly journals In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy

2012 ◽  
pp. 1251 ◽  
Author(s):  
Priyaveena Puvanakrishnan
Keyword(s):  
Gold Nanoparticles ◽  
Tumor Targeting ◽  
Particle Type ◽  
Dosing Strategy

scholarly journals Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Theranostics ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. 3168-3178 ◽  
Author(s):  
Huaxin Tan ◽  
Yazhou Huang ◽  
Jianghong Xu ◽  
Bo Chen ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Tumor Targeting ◽  
Functionalized Gold Nanoparticles ◽  
Spider Toxin

Spider toxin peptide lycosin-i functionalized gold nanoparticles for in vivo tumor targeting and therapy

Toxicon ◽  
2019 ◽  
Vol 158 ◽  
pp. S2
Author(s):  
Huaxin Tan ◽  
Yazhou Huang ◽  
Jianghong Xu ◽  
Bo Chen ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Tumor Targeting ◽  
Functionalized Gold Nanoparticles ◽  
Spider Toxin

Light-triggered crosslinking of gold nanoparticles for remarkably improved radiation therapy and computed tomography imaging of tumors

Nanomedicine ◽  
2019 ◽  
Vol 14 (22) ◽  
pp. 2941-2955 ◽  
Author(s):  
Xiaju Cheng ◽  
Rui Sun ◽  
Huawei Xia ◽  
Jianan Ding ◽  
Ling Yin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Poly Ethylene Glycol ◽  
Computed Tomography Imaging ◽  
Tomography Imaging ◽  
Poly Ethylene ◽  
Targeting Ability

Aim: We aimed to characterize the tumor-targeting and radiosensitization properties of the photo-responsive gold nanoparticles (AuNPs) decorated photolabile diazirine group and folic acid for improved radiotherapy and computed tomography imaging of tumors. Methods: Folic acid and photolabile diazirine group were covalently conjugated on the surface of AuNPs to afford the desired photo-responsive dAuNP-FA (AuNPs capped with poly(ethylene) glycol ligands bearing photolabile diazirine group and folic acid). The probes were intravenously injected into tumor-bearing mice followed by photocrosslinking upon 405 nm laser irradiation for radiotherapy and computed tomography imaging of tumors in vivo. Results: Light-triggered crosslinking of AuNPs in vivo remarkably enhanced the accumulation and retention of AuNPs within tumors. Conclusion: We have successfully developed a novel photo-responsive Au particle-based tumor theranostic probe showing remarkably improved tumor targeting ability and radiosensitization effect.

scholarly journals Gold nanoparticles for cancer theranostics — A brief update

2016 ◽  
Vol 09 (04) ◽  
pp. 1630004 ◽  
Author(s):  
Ning Zhao ◽  
Yongxu Pan ◽  
Zhen Cheng ◽  
Hongguang Liu
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Tumor Targeting ◽  
Drug Carriers ◽  
Cancer Diagnostics ◽  
Chemotherapeutic Drug ◽  
X Ray ◽  
Cancer Theranostics

Gold nanoparticles (AuNPs) exhibit superior optical and physical properties for more effective treatment of cancer through incorporating both diagnostic and therapeutic functions into one single platform. The ability to passively accumulate on tumor cells provides AuNPs the opportunity to become an attractive contrast agent for X-ray based computed tomography (CT) imaging in vivo. Because of facile surface modification, various size and shape of AuNPs have been extensively functionalized and applied as active nanoprobes and drug carriers for cancer targeted theranostics. Moreover, their capabilities on producing photoacoustic (PA) signals and photothermal effects have been used to image and treat tumor progression, respectively. Herein, we review the developments of AuNPs as cancer diagnostics and chemotherapeutic drug vector, summarizing strategies for tumor targeting and their applications in vitro and in vivo.

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

2019 ◽  
Vol 9 (2Apr) ◽  
Author(s):  
S Farahani ◽  
N Riyahi Alam ◽  
S Haghgoo ◽  
M Khoobi ◽  
Gh Geraily ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
3D Visualization ◽  
Energy Levels ◽  
Polymer Gel ◽  
External Radiotherapy ◽  
Dose Enhancement ◽  
Internal Radiotherapy ◽  
Boost Radiotherapy

Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lying tumors require much higher energy levels with greater penetration power, and investigations carried out in megavoltage energy range show contradictory results.Objective: In this study, we quantitatively assess and compare dose enhancement factors (DEFs) obtained through AuNPs under radiation of Cobalt-60 source (1.25MeV) versus Iridium-192 source (0.380 KeV) using MAGAT gel dosimeter.Material and Methods: MAGAT polymer gel in both pure and combined with 0.2 mM AuNPs was synthesized. In order to quantify the effect of energy on DEF, irradiation was carried out by Co-60 external radiotherapy and Ir-192 internal radiotherapy. Finally, readings of irradiated and non-irradiated gels were performed by MR imaging.Result: The radiation-induced R2 (1/T2) changes of the gel tubes doped with AuNPs compared to control samples, upon irradiation of beams released by Ir-192 source showed a significant dose enhancement (15.31% ±0.30) relative to the Co-60 external radiotherapy (5.85% ±0.14).Conclusion: This preliminary study suggests the feasibility of using AuNPs in radiation therapy (RT), especially in low-energy sources of brachytherapy. In addition, MAGAT polymer gel, as a powerful dosimeter, could be used for 3D visualization of radiation dose distribution of AuNPs in radiotherapy.

Correlation between in vitro and in vivo Data of Radiolabeled Peptide for Tumor Targeting

2019 ◽  
Vol 19 (12) ◽  
pp. 950-960
Author(s):  
Soghra Farzipour ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Tumor Targeting ◽  
Single Photon ◽  
Specific Binding ◽  
Specific Interaction ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Mixed Effect ◽  
Radiolabeled Peptides

Tumor-targeting peptides have been generally developed for the overexpression of tumor specific receptors in cancer cells. The use of specific radiolabeled peptide allows tumor visualization by single photon emission computed tomography (SPECT) and positron emission tomography (PET) tools. The high affinity and specific binding of radiolabeled peptide are focusing on tumoral receptors. The character of the peptide itself, in particular, its complex molecular structure and behaviors influence on its specific interaction with receptors which are overexpressed in tumor. This review summarizes various strategies which are applied for the expansion of radiolabeled peptides for tumor targeting based on in vitro and in vivo specific tumor data and then their data were compared to find any correlation between these experiments. With a careful look at previous studies, it can be found that in vitro unblock-block ratio was unable to correlate the tumor to muscle ratio and the success of radiolabeled peptide for in vivo tumor targeting. The introduction of modifiers’ approaches, nature of peptides, and type of chelators and co-ligands have mixed effect on the in vitro and in vivo specificity of radiolabeled peptides.

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