scholarly journals Hybrid Nanoparticles Modified by Hyaluronic Acid Loading an HSP90 Inhibitor as a Novel Delivery System for Subcutaneous and Orthotopic Colon Cancer Therapy

2021 ◽  
Vol Volume 16 ◽  
pp. 1743-1755
Author(s):  
Chenwei Pan ◽  
Tiaotiao Zhang ◽  
Shaoxun Li ◽  
Zhihua Xu ◽  
Binhui Pan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Delivery System ◽  
Hsp90 Inhibitor ◽  
Hybrid Nanoparticles ◽  
Acid Loading

Development of a controlled-release drug delivery system by encapsulating oxaliplatin into SPIO/MWNT nanoparticles for effective colon cancer therapy and magnetic resonance imaging

2016 ◽  
Vol 4 (12) ◽  
pp. 1742-1753 ◽  
Author(s):  
Pei-Chi Lee ◽  
Chien-Yu Lin ◽  
Cheng-Liang Peng ◽  
Ming-Jium Shieh
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Colon Cancer ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Resonance Imaging ◽  
Release Drug ◽  
Important Objective

The development of a controlled-release drug delivery system has been an important objective for cancer therapy.

Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 2-14
Author(s):  
Sahil Kumar ◽  
Bandna Sharma ◽  
Kiran Thakur ◽  
Tilak R. Bhardwaj ◽  
Deo N. Prasad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Near Ir ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

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