PEGylated Hyaluronic Acid-Modified Liposomal Delivery System with Anti-γ-Glutamylcyclotransferase siRNA for Drug-Resistant MCF-7 Breast Cancer Therapy

2015 ◽  
Vol 104 (2) ◽  
pp. 476-484 ◽  
Author(s):  
Rui Ran ◽  
Yayuan Liu ◽  
Huile Gao ◽  
Qifang Kuang ◽  
Qianyu Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Delivery System ◽  
Drug Resistant ◽  
Breast Cancer Therapy ◽  
Liposomal Delivery ◽  
Mcf 7

Multifunctional HER2-Antibody Conjugated Polymeric Nanocarrier-Based Drug Delivery System for Multi-Drug-Resistant Breast Cancer Therapy

2014 ◽  
Vol 6 (9) ◽  
pp. 6469-6480 ◽  
Author(s):  
Raju Vivek ◽  
Ramar Thangam ◽  
Varukattu NipunBabu ◽  
Chandrababu Rejeeth ◽  
Srinivasan Sivasubramanian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Resistant ◽  
Breast Cancer Therapy ◽  
Polymeric Nanocarrier

scholarly journals Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy

2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Breast Cancer Therapy

scholarly journals Co-delivery of baicalein and doxorubicin by hyaluronic acid decorated nanostructured lipid carriers for breast cancer therapy

Drug Delivery ◽  
2015 ◽  
Vol 23 (4) ◽  
pp. 1364-1368 ◽  
Author(s):  
Qian Liu ◽  
Jia Li ◽  
Gaobin Pu ◽  
Fang Zhang ◽  
Hongyan Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Nanostructured Lipid Carriers ◽  
Breast Cancer Therapy

Co-administration of biocompatible self-assembled polylactic acid–hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy

2018 ◽  
Vol 6 (19) ◽  
pp. 3163-3180 ◽  
Author(s):  
Caifeng Deng ◽  
Xiaohong Xu ◽  
Drunp Tashi ◽  
Yongmei Wu ◽  
Bingyin Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Polylactic Acid ◽  
Targeted Delivery ◽  
Metastatic Breast ◽  
Chemotherapeutic Drugs ◽  
Breast Cancer Therapy

The safe and efficient targeted delivery of chemotherapeutic drugs has remained a challenge in metastatic breast cancer therapy.

scholarly journals An analytical study of Trastuzumab-dendrimer-fluorine drug delivery system in breast cancer therapy in vitro

2021 ◽  
Vol 133 ◽  
pp. 111053
Author(s):  
Dorota Bartusik-Aebisher ◽  
Grzegorz Chrzanowski ◽  
Zuzanna Bober ◽  
David Aebisher
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Analytical Study ◽  
Breast Cancer Therapy

scholarly journals A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy

Drug Delivery ◽  
2021 ◽  
Vol 29 (1) ◽  
pp. 1-9
Author(s):  
Yun-Chang Zhang ◽  
Pei-Yu Zeng ◽  
Zhi-Qiang Ma ◽  
Zi-Yue Xu ◽  
Ze-Kun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Organic Framework

scholarly journals New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1623
Author(s):  
Diana Duarte ◽  
Nuno Vale
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Cell Viability ◽  
Cultured Cells ◽  
Fixed Ratio ◽  
Tumor Cell Line ◽  
New Combination ◽  
Breast Cancer Therapy ◽  
Almost All ◽  
Mcf 7

Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy. Cytotoxic effects of two antineoplastic agents alone and in combination with several antimalarials on MCF-7 tumor cell line was evaluated. Different concentrations in a fixed ratio were added to the cultured cells and incubated for 48 h. Cell viability was evaluated using MTT and SRB assays. Synergism was evaluated using the Chou-Talalay method. The results indicate doxorubicin (DOX) and paclitaxel (PTX) alone at concentrations of their IC50 and higher are cell growth inhibitors. Mefloquine, artesunate, and chloroquine at concentrations of their IC50 demonstrate anti-cancer activity. In combination, almost all antimalarials demonstrate higher ability than DOX and PTX alone to decrease cell viability at concentrations of IC50 and lower than their IC50. The combination of chloroquine, artesunate and mefloquine with DOX and PTX was synergic (CI < 1). The combination of DOX and mefloquine after 48 h incubation demonstrated the highest cytotoxicity against MCF-7 cells, and the combination of DOX and artesunate was the most synergic. These results suggest antimalarials could act synergistically with DOX/PTX for breast cancer therapy.

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