scholarly journals Cancer Cell–Membrane Biomimetic Boron Nitride Nanospheres for Targeted Cancer Therapy

2021 ◽  
Vol Volume 16 ◽  
pp. 2123-2136
Author(s):  
Shini Feng ◽  
Yajing Ren ◽  
Hui Li ◽  
Yunfei Tang ◽  
Jinyu Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Boron Nitride ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Targeted Cancer Therapy

scholarly journals Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small ◽  
2021 ◽  
pp. 2006484
Author(s):  
Fatemeh Oroojalian ◽  
Mohammad Beygi ◽  
Behzad Baradaran ◽  
Ahad Mokhtarzadeh ◽  
Mohammad‐Ali Shahbazi
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Immune Cell ◽  
Targeted Cancer Therapy ◽  
Biomimetic Nanoparticles

Cancer Cell Membrane Camouflaged Nanoparticles to Realize Starvation Therapy Together with Checkpoint Blockades for Enhancing Cancer Therapy

ACS Nano ◽  
2019 ◽  
Vol 13 (3) ◽  
pp. 2849-2857 ◽  
Author(s):  
Wei Xie ◽  
Wei-Wei Deng ◽  
Minghui Zan ◽  
Lang Rao ◽  
Guang-Tao Yu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Cancer Cell

Cancer Cell Membrane Technology for Cancer Therapy

ChemNanoMat ◽  
2020 ◽  
Vol 6 (12) ◽  
pp. 1712-1729
Author(s):  
Chethana Rao ◽  
Pushpendra Mani Mishra ◽  
Aditya Yadav ◽  
Chayan Kanti Nandi
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Membrane Technology

scholarly journals Cancer Cell Membrane Decorated Silica Nanoparticle Loaded with miR495 and Doxorubicin to Overcome Drug Resistance for Effective Lung Cancer Therapy

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Jinyuan He ◽  
Chulian Gong ◽  
Jie Qin ◽  
Mingan Li ◽  
Shaohong Huang
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Silica Nanoparticle ◽  
Glycoprotein P ◽  
Lung Cancer Therapy

Abstract Current cancer therapy usually succumbs to many extracellular and intracellular barriers, among which untargeted distribution and multidrug resistance (MDR) are two important difficulties responsible for poor outcome of many drug delivery systems (DDS). Here, in our study, the dilemma was addressed by developing a cancer cell membrane (CCM)-coated silica (SLI) nanoparticles to co-deliver miR495 with doxorubicin (DOX) for effective therapy of lung cancer (CCM/SLI/R-D). The homologous CCM from MDR lung cancer cells (A549/DOX) was supposed to increase the tumor-homing property of the DDS to bypass the extracellular barriers. Moreover, the MDR of cancer cells were conquered through downregulation of P-glycoprotein (P-gp) expression using miR495. It was proved that miR495 could significantly decrease the expression of P-gp which elevated intracellular drug accumulation in A549/DOX. The in vitro and in vivo results exhibited that CCM/SLI/R-D showed a greatly enhanced therapeutic effect on A549/DOX, which was superior than applying miR495 or DOX alone. The preferable effect of CCM/SLI/R-D on conquering the MDR in lung cancer provides a novel alternative for effective chemotherapy of MDR cancers.

scholarly journals Cancer Therapy: Cancer Cell Membrane Camouflaged Semi‐Yolk@Spiky‐Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy (Small 39/2020)

Small ◽  
2020 ◽  
Vol 16 (39) ◽  
pp. 2070215
Author(s):  
Mengyun Zhou ◽  
Yi Xing ◽  
Xiaoyu Li ◽  
Xin Du ◽  
Tailin Xu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Cancer Cell

scholarly journals PIWIL1 promotes gastric cancer via a piRNA-independent mechanism

2020 ◽  
Vol 117 (36) ◽  
pp. 22390-22401 ◽  
Author(s):  
Shuo Shi ◽  
Zhen-Zhen Yang ◽  
Sanhong Liu ◽  
Fan Yang ◽  
Haifan Lin
Keyword(s):  
Gastric Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Noncoding Rna ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Targeted Cancer Therapy ◽  
Gastric Cancer Cells ◽  
Piwi Domain

Targeted cancer therapy aims to achieve specific elimination of cancerous but not normal cells. Recently, PIWI proteins, a subfamily of the PAZ-PIWI domain (PPD) protein family, have emerged as promising candidates for targeted cancer therapy. PPD proteins are essential for small noncoding RNA pathways. The Argonaute subfamily partners with microRNA and small interfering RNA, whereas the PIWI subfamily partners with PIWI-interacting RNA (piRNA). Both PIWI proteins and piRNA are mostly expressed in the germline and best known for their function in transposon silencing, with no detectable function in mammalian somatic tissues. However, PIWI proteins become aberrantly expressed in multiple types of somatic cancers, thus gaining interest in targeted therapy. Despite this, little is known about the regulatory mechanism of PIWI proteins in cancer. Here we report that one of the four PIWI proteins in humans, PIWIL1, is highly expressed in gastric cancer tissues and cell lines. Knocking out the PIWIL1 gene (PIWIL1-KO) drastically reduces gastric cancer cell proliferation, migration, metastasis, and tumorigenesis. RNA deep sequencing of gastric cancer cell line SNU-1 reveals that KO significantly changes the transcriptome, causing the up-regulation of most of its associated transcripts. Surprisingly, few bona fide piRNAs exist in gastric cancer cells. Furthermore, abolishing the piRNA-binding activity of PIWIL1 does not affect its oncogenic function. Thus, PIWIL1 function in gastric cancer cells is independent of piRNA. This piRNA-independent regulation involves interaction with the UPF1-mediated nonsense-mediated mRNA decay (NMD) mechanism. Altogether, our findings reveal a piRNA-independent function of PIWIL1 in promoting gastric cancer.

scholarly journals Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy

2014 ◽  
Vol 6 (4) ◽  
pp. e95-e95 ◽  
Author(s):  
Qiaoling Liu ◽  
Chen Jin ◽  
Yanyue Wang ◽  
Xiaohong Fang ◽  
Xiaobing Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cell ◽  
Targeted Cancer Therapy ◽  
Cell Recognition ◽  
Specific Cancer

Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy

Nano Research ◽  
2022 ◽  
Author(s):  
Fudan Dong ◽  
Qikun Jiang ◽  
Lingxiao Li ◽  
Tian Liu ◽  
Shiyi Zuo ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Energy Depletion

scholarly journals Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

Nanoscale ◽  
2016 ◽  
Vol 8 (13) ◽  
pp. 6981-6985 ◽  
Author(s):  
S. Krishnamurthy ◽  
M. K. Gnanasammandhan ◽  
C. Xie ◽  
K. Huang ◽  
M. Y. Cui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Cellular Uptake ◽  
Breast Cancer Cell Lines ◽  
Core Shell ◽  
Targeted Cancer Therapy ◽  
Monocyte Cell ◽  
Coated Nanoparticle ◽  
Mcf 7

Core–shell type ‘nanoghosts’ were synthesized with a biodegradable PLGA core and a monocyte cell membrane-derived shell. The ∼200 nm doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

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