scholarly journals Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration

2020 ◽  
Vol Volume 15 ◽  
pp. 5911-5926
Author(s):  
Jiayi Yang ◽  
Zhiyi Chen ◽  
Daoyan Pan ◽  
Huaizhi Li ◽  
Jie Shen
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Umbilical Cord ◽  
Skin Regeneration ◽  
Pluronic F127 ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals Mesenchymal stem cell-laden, personalized 3D scaffolds with controlled structure and fiber alignment promote diabetic wound healing

2020 ◽  
Vol 108 ◽  
pp. 153-167 ◽  
Author(s):  
Shixuan Chen ◽  
Hongjun Wang ◽  
Yajuan Su ◽  
Johnson V. John ◽  
Alec McCarthy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Diabetic Wound ◽  
3D Scaffolds ◽  
Fiber Alignment ◽  
Diabetic Wound Healing ◽  
Controlled Structure

scholarly journals Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Shixuan Chen ◽  
Junbin Shi ◽  
Min Zhang ◽  
Yinghua Chen ◽  
Xueer Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Anti Inflammatory

scholarly journals Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration: Erratum

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10174-10175
Author(s):  
Chenggui Wang ◽  
Min Wang ◽  
Tianzhen Xu ◽  
Xingxing Zhang ◽  
Cai Lin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Regeneration ◽  
Self Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing

2020 ◽  
Vol 15 (2) ◽  
pp. 1277-1293 ◽  
Author(s):  
Jolanta Gorecka ◽  
Xixiang Gao ◽  
Arash Fereydooni ◽  
Biraja C Dash ◽  
Jiesi Luo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Smooth Muscle ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Diabetic Wound ◽  
Collagen Scaffolds ◽  
Diabetic Wound Healing ◽  
Induced Pluripotent ◽  
Angiogenic Cytokines

Aim: To assess the potential of human induced pluripotent stem cell-derived smooth muscle cells (hiPSC-SMC) to accelerate diabetic wound healing. Methods: hiPSC-SMC were embedded in 3D collagen scaffolds and cultured in vitro for 72 h; scaffolds were then applied to diabetic, nude mouse, splinted back wounds to assess in vivo healing. Cultured medium after scaffold incubation was collected and analyzed for expression of pro-angiogenic cytokines. Results: hiPSC-SMC secrete increased concentration of pro-angiogenic cytokines, compared with murine adipose derived stem cells. Delivery of hiPSC-SMC-containing collagen scaffolds accelerates diabetic wound healing and is associated with an increased number of total and M2 type macrophages. Conclusion: hiPSC-SMC promote angiogenesis and accelerate diabetic wound healing, making them a promising new candidate for treatment of diabetic wounds.

Integrin-binding pro-survival peptide engineered silk fibroin nanosheets for diabetic wound healing and skin regeneration

2020 ◽  
Vol 398 ◽  
pp. 125617
Author(s):  
Huishang Yang ◽  
Chen Lai ◽  
Chengkai Xuan ◽  
Muyuan Chai ◽  
Xuemin Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Skin Regeneration ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals Enhanced Healing of Diabetic Wounds by Subcutaneous Administration of Human Umbilical Cord Derived Stem Cells and Their Conditioned Media

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Chandrama Shrestha ◽  
Liling Zhao ◽  
Ke Chen ◽  
Honghui He ◽  
Zhaohui Mo
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Umbilical Cord ◽  
Subcutaneous Administration ◽  
Conditioned Media ◽  
Human Umbilical Cord ◽  
Diabetic Wound ◽  
Significant Difference ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds

Objective. Mesenchymal stem cells (MSCs) isolated from the umbilical cord and their conditioned media (CM) can be easily obtained and refined compared with stem cells from other sources. Here, we explore the possibility of the benefits of these cells in healing diabetic wounds.Methodology and Results. Delayed wound healing animal models were established by making a standard wound on the dorsum of eighteen db/db mice, which were divided into three groups with six mice in each: groups I, II, and III received PBS, UC-MSC, and CM, respectively. UC-MSC and their CM significantly accelerated wound closure compared to PBS-treated wounds, and it was most rapid in CM-injected wounds. In day-14 wounds, significant difference in capillary densities among the three groups was noted (n=6;P<0.05), and higher levels of VEGF, PDGF, and KGF expression in the CM- and UC-MSC-injected wounds compared to the PBS-treated wounds were seen. The expression levels of PDGF-βand KGF were higher in CM-treated wounds than those in UC-MSC-treated wounds.Conclusion. Both the transplantation of UC-MSC and their CM are beneficial to diabetic wound healing, and CM has been shown to be therapeutically better than UC-MSC, at least in the context of diabetic wound healing.

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