scholarly journals Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Shixuan Chen ◽  
Junbin Shi ◽  
Min Zhang ◽  
Yinghua Chen ◽  
Xueer Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Anti Inflammatory

scholarly journals Mesenchymal stem cell-laden, personalized 3D scaffolds with controlled structure and fiber alignment promote diabetic wound healing

2020 ◽  
Vol 108 ◽  
pp. 153-167 ◽  
Author(s):  
Shixuan Chen ◽  
Hongjun Wang ◽  
Yajuan Su ◽  
Johnson V. John ◽  
Alec McCarthy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Diabetic Wound ◽  
3D Scaffolds ◽  
Fiber Alignment ◽  
Diabetic Wound Healing ◽  
Controlled Structure

scholarly journals Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing

2020 ◽  
Vol 15 (2) ◽  
pp. 1277-1293 ◽  
Author(s):  
Jolanta Gorecka ◽  
Xixiang Gao ◽  
Arash Fereydooni ◽  
Biraja C Dash ◽  
Jiesi Luo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Smooth Muscle ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Diabetic Wound ◽  
Collagen Scaffolds ◽  
Diabetic Wound Healing ◽  
Induced Pluripotent ◽  
Angiogenic Cytokines

Aim: To assess the potential of human induced pluripotent stem cell-derived smooth muscle cells (hiPSC-SMC) to accelerate diabetic wound healing. Methods: hiPSC-SMC were embedded in 3D collagen scaffolds and cultured in vitro for 72 h; scaffolds were then applied to diabetic, nude mouse, splinted back wounds to assess in vivo healing. Cultured medium after scaffold incubation was collected and analyzed for expression of pro-angiogenic cytokines. Results: hiPSC-SMC secrete increased concentration of pro-angiogenic cytokines, compared with murine adipose derived stem cells. Delivery of hiPSC-SMC-containing collagen scaffolds accelerates diabetic wound healing and is associated with an increased number of total and M2 type macrophages. Conclusion: hiPSC-SMC promote angiogenesis and accelerate diabetic wound healing, making them a promising new candidate for treatment of diabetic wounds.

scholarly journals ECM‐derived Scaffolds: Scaffolds Functionalized with Matrix from Induced Pluripotent Stem Cell Fibroblasts for Diabetic Wound Healing (Adv. Healthcare Mater. 16/2020)

2020 ◽  
Vol 9 (16) ◽  
pp. 2070051
Author(s):  
Francesco Santarella ◽  
Rukmani Sridharan ◽  
Milica Marinkovic ◽  
Ronaldo Jose Farias Correa Do Amaral ◽  
Brenton Cavanagh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Induced Pluripotent
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