scholarly journals Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites

2011 ◽  
pp. 2155 ◽  
Author(s):  
Elsayed Elsherbini
Keyword(s):  
Magnetic Nanocomposites ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia

Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging

2011 ◽  
Vol 29 (2) ◽  
pp. 272-280 ◽  
Author(s):  
Alsayed A.M. Elsherbini ◽  
Mahmoud Saber ◽  
Mohamed Aggag ◽  
Ahmed El-Shahawy ◽  
Hesham A.A. Shokier
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Magnetic Nanoparticle ◽  
Resonance Imaging ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia

scholarly journals Tuning Optical and Granulometric Properties of Gold Nanostructures Synthesized with the Aid of Different Types of Honeys for Microwave-Induced Hyperthermia

Materials ◽  
2019 ◽  
Vol 12 (6) ◽  
pp. 898
Author(s):  
Anna Dzimitrowicz ◽  
Piotr Cyganowski ◽  
Piotr Jamroz ◽  
Dorota Jermakowicz-Bartkowiak ◽  
Malgorzata Rzegocka ◽  
...  
Keyword(s):  
X Ray Diffraction ◽  
Hyperthermia Treatment ◽  
X Ray ◽  
Induced Hyperthermia ◽  
Transmission Electron ◽  
Fourier Transformation Infrared Spectroscopy ◽  
Ft Ir ◽  
Honey Solution ◽  
Size Controlled

Size-controlled gold nanoparticles (AuNPs) were synthesised with solutions of three types of Polish honeys (lime, multiflower, honeydew) and used in microwave-induced hyperthermia cancer treatment. Optical and structural properties of nanostructures were optimized in reference to measurements made by using UV/Vis absorption spectrophotometry (UV/Vis), transmission electron microscopy (TEM) supported by energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and attenuated total reflectance Fourier transformation infrared spectroscopy (ATR FT-IR). In addition, concentrations of reducing sugars and polyphenols of honeys applied were determined to reveal the role of these chemical compounds in green synthesis of AuNPs. It was found that the smallest AuNPs (20.6 ± 23.3 nm) were produced using a 20% (w/v) multiflower aqueous honey solution and 25 mg·L−1 of Au(III) ions. These AuNPs were then employed in microwave-induced hyperthermia in a system simulating metastatic tissues. This research illustrated that AuNPs, as produced with the aid of a multiflower honey solution, could be suitably used for microwave-induced heating of cancer. A fluid containing resultant Au nanostructures, as compared to water, revealed facilitated heating and the ability to maintain a temperature of 45 °C required for hyperthermia treatment.

scholarly journals Solving the Time- and Frequency-Multiplexed Problem of Constrained Radiofrequency Induced Hyperthermia

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1072 ◽  
Author(s):  
Andre Kuehne ◽  
Eva Oberacker ◽  
Helmar Waiczies ◽  
Thoralf Niendorf
Keyword(s):  
High Performance ◽  
Safety Management ◽  
Pure Water ◽  
Semidefinite Program ◽  
Global Optimality ◽  
Rf Heating ◽  
Frequency Range ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia ◽  
Wide Range

Targeted radiofrequency (RF) heating induced hyperthermia has a wide range of applications, ranging from adjunct anti-cancer treatment to localized release of drugs. Focal RF heating is usually approached using time-consuming nonconvex optimization procedures or approximations, which significantly hampers its application. To address this limitation, this work presents an algorithm that recasts the problem as a semidefinite program and quickly solves it to global optimality, even for very large (human voxel) models. The target region and a desired RF power deposition pattern as well as constraints can be freely defined on a voxel level, and the optimum application RF frequencies and time-multiplexed RF excitations are automatically determined. 2D and 3D example applications conducted for test objects containing pure water (rtarget = 19 mm, frequency range: 500–2000 MHz) and for human brain models including brain tumors of various size (r1 = 20 mm, r2 = 30 mm, frequency range 100–1000 MHz) and locations (center, off-center, disjoint) demonstrate the applicability and capabilities of the proposed approach. Due to its high performance, the algorithm can solve typical clinical problems in a few seconds, making the presented approach ideally suited for interactive hyperthermia treatment planning, thermal dose and safety management, and the design, rapid evaluation, and comparison of RF applicator configurations.

Nd:YAG laser-induced hyperthermia treatment of spontaneously occurring veterinary head and neck tumors

1991 ◽  
Vol 11 (4) ◽  
pp. 351-355 ◽  
Author(s):  
Masoud Panjehpour ◽  
Bergein F. Overholt ◽  
Donita L. Frazier ◽  
Edward R. Klebanow
Keyword(s):  
Head And Neck ◽  
Nd:Yag Laser ◽  
Head And Neck Tumors ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia ◽  
Neck Tumors

scholarly journals Prediction of Gold Nanoparticle and Microwave-Induced Hyperthermia Effects on Tumor Control via a Simulation Approach

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 167 ◽  
Author(s):  
Nikolaos Dimitriou ◽  
Athanasia Pavlopoulou ◽  
Ioanna Tremi ◽  
Vassilis Kouloulias ◽  
Georgios Tsigaridas ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cell Death ◽  
Critical Role ◽  
Heat Shock Protein 90 ◽  
Absorption Efficiency ◽  
Tumor Control ◽  
Hyperthermia Treatment ◽  
Au Nps ◽  
Induced Hyperthermia ◽  
Tumor Growth Model

Hyperthermia acts as a powerful adjuvant to radiation therapy and chemotherapy. Recent advances show that gold nanoparticles (Au-NPs) can mediate highly localized thermal effects upon interaction with laser radiation. The purpose of the present study was to investigate via in silico simulations the mechanisms of Au-NPs and microwave-induced hyperthermia, in correlation to predictions of tumor control (biological endpoints: tumor shrinkage and cell death) after hyperthermia treatment. We also study in detail the dependence of the size, shape and structure of the gold nanoparticles on their absorption efficiency, and provide general guidelines on how one could modify the absorption spectrum of the nanoparticles in order to meet the needs of specific applications. We calculated the hyperthermia effect using two types of Au-NPs and two types of spherical tumors (prostate and melanoma) with a radius of 3 mm. The plasmon peak for the 30 nm Si-core Au-coated NPs and the 20 nm Au-NPs was found at 590 nm and 540 nm, respectively. Considering the plasmon peaks and the distribution of NPs in the tumor tissue, the induced thermal profile was estimated for different intervals of time. Predictions of hyperthermic cell death were performed by adopting a three-state mathematical model, where “three-state” includes (i) alive, (ii) vulnerable, and (iii) dead states of the cell, and it was coupled with a tumor growth model. Our proposed methodology and preliminary results could be considered as a proof-of-principle for the significance of simulating accurately the hyperthermia-based tumor control involving the immune system. We also propose a method for the optimization of treatment by overcoming thermoresistance by biological means and specifically through the targeting of the heat shock protein 90 (HSP90), which plays a critical role in the thermotolerance of cells and tissues.

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