Uncertainties in the Micro/nano-Particles Induced Hyperthermia Treatment on Tumor Subject to External EM Field

2006 ◽  
Author(s):  
Zhong-Shan Deng ◽  
Jing Liu
Keyword(s):  
Nano Particles ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia ◽  
Em Field

Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging

2011 ◽  
Vol 29 (2) ◽  
pp. 272-280 ◽  
Author(s):  
Alsayed A.M. Elsherbini ◽  
Mahmoud Saber ◽  
Mohamed Aggag ◽  
Ahmed El-Shahawy ◽  
Hesham A.A. Shokier
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Magnetic Nanoparticle ◽  
Resonance Imaging ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia

Oncological Study of Thin Layers of Imatinib Molecule Nanostructure for Chronic Myelogenous Leukemia (CML), Acute Lymphocytic Leukemia (ALL), Philadelphia Chromosome-Positive (Ph+), Gastrointestinal Stromal Tumors (GIST), Hypereosinophilic Syndrome (HES), Chronic Eosinophilic Leukemia (CEL), Systemic Mastocytosis and Myelodysplastic Syndrome Treatment

2020 ◽  
Vol 12 (6) ◽  
pp. 753-760
Author(s):  
Alireza Heidari
Keyword(s):  
Temperature Distribution ◽  
Normal Tissue ◽  
Hypereosinophilic Syndrome ◽  
Thin Layers ◽  
Myelogenous Leukemia ◽  
Nano Particles ◽  
Maximum Temperature ◽  
Hyperthermia Treatment ◽  
Wave Source ◽  
Magnetic Nano Particles

The interest in exploring more effective methods for cancer treatment has increased widely in recent years. In clinical studies it is difficult to determine the temperature distribution in both normal tissue and in tumor during hyperthermia treatment since temperature can be measured in limited number of positions in tissue or tumor. Simulation studies can play crucial role in physician's perception of the temperature distribution in tissue. Hyperthermia treatment is facing some unsolved problems such as the appropriate dosage of magnetic Nano particles required to achieve the optimum temperature which results in apoptosis in tumor cells. In this study, a 2D computational model is created in COMSOL Metaphysics in order to analyze temperature distribution in both normal tissue and tumor during hyperthermia treatment using various dosages of magnetic Nano particles. Temperature distribution is achieved by considering various layers from wave source through to the tumor and also by taking into account the amount of heat generated through the Brownian rotation and the Neel relaxation. Simulations of a spherical tumor located in ellipse tissue were designed. A systematical variation in dosage has been performed. Temperature distribution and maximum temperature in steady state and effect of the dosage of Nano particles.

scholarly journals Tuning Optical and Granulometric Properties of Gold Nanostructures Synthesized with the Aid of Different Types of Honeys for Microwave-Induced Hyperthermia

Materials ◽  
2019 ◽  
Vol 12 (6) ◽  
pp. 898
Author(s):  
Anna Dzimitrowicz ◽  
Piotr Cyganowski ◽  
Piotr Jamroz ◽  
Dorota Jermakowicz-Bartkowiak ◽  
Malgorzata Rzegocka ◽  
...  
Keyword(s):  
X Ray Diffraction ◽  
Hyperthermia Treatment ◽  
X Ray ◽  
Induced Hyperthermia ◽  
Transmission Electron ◽  
Fourier Transformation Infrared Spectroscopy ◽  
Ft Ir ◽  
Honey Solution ◽  
Size Controlled

Size-controlled gold nanoparticles (AuNPs) were synthesised with solutions of three types of Polish honeys (lime, multiflower, honeydew) and used in microwave-induced hyperthermia cancer treatment. Optical and structural properties of nanostructures were optimized in reference to measurements made by using UV/Vis absorption spectrophotometry (UV/Vis), transmission electron microscopy (TEM) supported by energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and attenuated total reflectance Fourier transformation infrared spectroscopy (ATR FT-IR). In addition, concentrations of reducing sugars and polyphenols of honeys applied were determined to reveal the role of these chemical compounds in green synthesis of AuNPs. It was found that the smallest AuNPs (20.6 ± 23.3 nm) were produced using a 20% (w/v) multiflower aqueous honey solution and 25 mg·L−1 of Au(III) ions. These AuNPs were then employed in microwave-induced hyperthermia in a system simulating metastatic tissues. This research illustrated that AuNPs, as produced with the aid of a multiflower honey solution, could be suitably used for microwave-induced heating of cancer. A fluid containing resultant Au nanostructures, as compared to water, revealed facilitated heating and the ability to maintain a temperature of 45 °C required for hyperthermia treatment.

scholarly journals Solving the Time- and Frequency-Multiplexed Problem of Constrained Radiofrequency Induced Hyperthermia

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1072 ◽  
Author(s):  
Andre Kuehne ◽  
Eva Oberacker ◽  
Helmar Waiczies ◽  
Thoralf Niendorf
Keyword(s):  
High Performance ◽  
Safety Management ◽  
Pure Water ◽  
Semidefinite Program ◽  
Global Optimality ◽  
Rf Heating ◽  
Frequency Range ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia ◽  
Wide Range

Targeted radiofrequency (RF) heating induced hyperthermia has a wide range of applications, ranging from adjunct anti-cancer treatment to localized release of drugs. Focal RF heating is usually approached using time-consuming nonconvex optimization procedures or approximations, which significantly hampers its application. To address this limitation, this work presents an algorithm that recasts the problem as a semidefinite program and quickly solves it to global optimality, even for very large (human voxel) models. The target region and a desired RF power deposition pattern as well as constraints can be freely defined on a voxel level, and the optimum application RF frequencies and time-multiplexed RF excitations are automatically determined. 2D and 3D example applications conducted for test objects containing pure water (rtarget = 19 mm, frequency range: 500–2000 MHz) and for human brain models including brain tumors of various size (r1 = 20 mm, r2 = 30 mm, frequency range 100–1000 MHz) and locations (center, off-center, disjoint) demonstrate the applicability and capabilities of the proposed approach. Due to its high performance, the algorithm can solve typical clinical problems in a few seconds, making the presented approach ideally suited for interactive hyperthermia treatment planning, thermal dose and safety management, and the design, rapid evaluation, and comparison of RF applicator configurations.

scholarly journals Electro paramagnetic resonance and magnetization measurements of metal-substituted hydroxyapatites used in hyperthermia applications

2017 ◽  
pp. 5024-5032
Author(s):  
Dr Hany Kamal
Keyword(s):  
Magnetic Field ◽  
Hysteresis Loops ◽  
Ferromagnetic Material ◽  
Nano Particles ◽  
Stoichiometric Ratio ◽  
Hyperthermia Treatment ◽  
Paramagnetic Resonance ◽  
Transmission Electron ◽  
Diffraction Patterns ◽  
Metal Doped

Pure and metal doped hydroxyapatite samples nano-particles were prepared by the wet chemical method. Copper and cobalt is used in doping hydroxyapatite. Sample was prepared without change in the stoichiometric ratio of Ca/P and Ca+M/P inside the structure of HA (M;metal). Sample was characterized by electron paramagnetic resonance, magnetization, transmission electron microscope and electron diffraction. Samples posses the highest value of magnetic susceptibility was chosen for more study to test their ability for application in the field of hyperthermia treatment of bone tumors. Magnetization curves were obtained for samples to study their behavior under the effect of magnetic field. The sample doped with copper and cobalt exhibited hysteresis loops which are characteristic for the magnetic materials. The samples were classified to be ferromagnetic material. Sample prepared by mixing Cu and co had the highest values of saturation magnetization (MS), area (A) enclosed within the hysteresis loop and magnetic anisotropy which represent an indicator of the energy generated in the material under the effect of magnetic field, and hence the amount of heat produced by the sample.  TEM and EDP techniques were used to study the internal structure of these samples. The micrographs and the diffraction patterns showed and confirmed the presence of crystal structures within the samples. The particle size was calculated from the micrographs and found to be in the range of nanometer for all the selected samples.

Nd:YAG laser-induced hyperthermia treatment of spontaneously occurring veterinary head and neck tumors

1991 ◽  
Vol 11 (4) ◽  
pp. 351-355 ◽  
Author(s):  
Masoud Panjehpour ◽  
Bergein F. Overholt ◽  
Donita L. Frazier ◽  
Edward R. Klebanow
Keyword(s):  
Head And Neck ◽  
Nd:Yag Laser ◽  
Head And Neck Tumors ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia ◽  
Neck Tumors

scholarly journals Prediction of Gold Nanoparticle and Microwave-Induced Hyperthermia Effects on Tumor Control via a Simulation Approach

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 167 ◽  
Author(s):  
Nikolaos Dimitriou ◽  
Athanasia Pavlopoulou ◽  
Ioanna Tremi ◽  
Vassilis Kouloulias ◽  
Georgios Tsigaridas ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cell Death ◽  
Critical Role ◽  
Heat Shock Protein 90 ◽  
Absorption Efficiency ◽  
Tumor Control ◽  
Hyperthermia Treatment ◽  
Au Nps ◽  
Induced Hyperthermia ◽  
Tumor Growth Model

Hyperthermia acts as a powerful adjuvant to radiation therapy and chemotherapy. Recent advances show that gold nanoparticles (Au-NPs) can mediate highly localized thermal effects upon interaction with laser radiation. The purpose of the present study was to investigate via in silico simulations the mechanisms of Au-NPs and microwave-induced hyperthermia, in correlation to predictions of tumor control (biological endpoints: tumor shrinkage and cell death) after hyperthermia treatment. We also study in detail the dependence of the size, shape and structure of the gold nanoparticles on their absorption efficiency, and provide general guidelines on how one could modify the absorption spectrum of the nanoparticles in order to meet the needs of specific applications. We calculated the hyperthermia effect using two types of Au-NPs and two types of spherical tumors (prostate and melanoma) with a radius of 3 mm. The plasmon peak for the 30 nm Si-core Au-coated NPs and the 20 nm Au-NPs was found at 590 nm and 540 nm, respectively. Considering the plasmon peaks and the distribution of NPs in the tumor tissue, the induced thermal profile was estimated for different intervals of time. Predictions of hyperthermic cell death were performed by adopting a three-state mathematical model, where “three-state” includes (i) alive, (ii) vulnerable, and (iii) dead states of the cell, and it was coupled with a tumor growth model. Our proposed methodology and preliminary results could be considered as a proof-of-principle for the significance of simulating accurately the hyperthermia-based tumor control involving the immune system. We also propose a method for the optimization of treatment by overcoming thermoresistance by biological means and specifically through the targeting of the heat shock protein 90 (HSP90), which plays a critical role in the thermotolerance of cells and tissues.

Heating Effects of the Magnetic-Nanoparticle Enhanced Hyperthermia Targeting Tumors Underneath the Ribs

2013 ◽  
Author(s):  
Chao Jin ◽  
Zhi Zhu He ◽  
Jing Liu
Keyword(s):  
Liver Tumor ◽  
Thermal Effects ◽  
Bone Structure ◽  
Nano Particles ◽  
Tumor Treatment ◽  
Heating Effects ◽  
Parametric Studies ◽  
Em Field ◽  
Electromagnetic Hyperthermia ◽  
Magnetic Nano Particles

Aiming at providing a detailed disclosure on the thermal effects of EM (electromagnetic) hyperthermia on the liver tumor underneath the ribs, this paper has numerically provided comprehensive interpretations on the heating effects of magnetic nano-particles induced hyperthermia for target tumor treatment. The results revealed the following factors: (1) The existing of bone structure, i.e. ribs has an inevitable effect on the distribution of EM field; specifically, due to its lower dielectric property, the bone structure seemingly acts as a barrier to attenuate the access of EM energy into the tissue, especially the tumor in the deep body. (2) Using higher dosage or bigger size magnetic nano-particles have greatly enhanced the temperature elevation of targeted tumor tissue and thereby obtain good performance of hyperthermia. (3) Further parametric studies indicated that a worse heating effect would be obtained when utilizing external EM field with a higher frequency of 10MHz; while higher strength of EM field would evidently enhance the heating effects of such EM hyperthermia. The present study would promote the understandings of thermal effects on the specific organs in EM hyperthermia, and the findings are expected to provide valuable guidance for planning an accurate dosage in clinical liver tumor thermal ablation.

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