scholarly journals Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells

2018 ◽  
Vol Volume 13 ◽  
pp. 7549-7563 ◽  
Author(s):  
Wenting Xu ◽  
Eun Ju Bae ◽  
Mi-Kyung Lee
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Solid Lipid Nanoparticles ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Lipid Nanoparticles ◽  
Intracellular Uptake ◽  
Solid Lipid

scholarly journals THE EFFECT OF SOLID LIPID NANOPARTICLES ON TAMOXIFEN-RESISTANT BREAST CANCER CELLS

2016 ◽  
Vol 8 (2) ◽  
pp. 43 ◽  
Author(s):  
Gamze Guney Eskiler ◽  
Gulsah Cecener ◽  
Gokhan Dikmen ◽  
Lutfi Genc ◽  
Unal Egeli
Keyword(s):  
Breast Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Solid Lipid Nanoparticles ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Apoptotic Activity

<p class="lead">To overcome the acquired Tamoxifen (Tam) resistance in Tam-resistant breast cancer cells without damaging normal cells, we have examined the therapeutic efficacy of Tam-loaded solid lipid nanoparticles (SLNs). Tam-loaded SLNs were produced by hot homogenization method. After characterization, <em>in vitro</em> cytotoxic and apoptotic activity of Tam-SLNs were evaluated in MCF7, MCF7-TamR (Tam-resistant breast cancer cells) and MCF10A cells. Tam-SLNs had an average size nearly 300 nm and a zeta potential of approximately-40 mV. <em>In vitro</em> cytotoxicity results showed that Tam-SLNs indicated the cytotoxic and apoptotic activity on MCF7 and MCF7-TamR cells. We found that MCF7-TamR cell viability was also suppressed significantly by Tam-SLNs and thus, Tam-SLNs could delay and overcome Tam-resistance (p&lt;0.05). Furthermore, the Tam-SLNs did not induce apoptosis on MCF10A control cells. The lowest MCF10A cell viability was 83.0% whereas MCF7 and MCF7-TamR (R↔ and R↑) cells viability are reduced to 21.98%, 27.5% and 29.4% at 10 µM of Tam-SLNs, respectively (p&lt;0.05). The obtained results were supported by apoptosis assays. SLNs-delivery system provided therapeutic efficacy to overcome Tam-resistance thanks to unique features of SLNs including small size, drug accumulation in the tumor site and controlled drug release. Therefore, Tam-SLNs may have therapeutic potential for the treatment of TAM-resistant breast cancer.</p>

scholarly journals Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1814 ◽  
Author(s):  
Wenrui Wang ◽  
Lingyu Zhang ◽  
Tiantian Chen ◽  
Wen Guo ◽  
Xunxia Bao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Solid Lipid Nanoparticles ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Lipid Nanoparticles ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Solid Lipid ◽  
Anticancer Effects
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