scholarly journals Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1814 ◽  
Author(s):  
Wenrui Wang ◽  
Lingyu Zhang ◽  
Tiantian Chen ◽  
Wen Guo ◽  
Xunxia Bao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Solid Lipid Nanoparticles ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Lipid Nanoparticles ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Solid Lipid ◽  
Anticancer Effects

Anticancer effects of brucine and gemcitabine combination in MCF-7 human breast cancer cells

2014 ◽  
Vol 29 (5) ◽  
pp. 484-490 ◽  
Author(s):  
Mamatha Serasanambati ◽  
Shanmuga Reddy Chilakapati ◽  
Pavan Kumar Manikonda ◽  
Jagadeeswara Reddy Kanala ◽  
Damodar Reddy Chilakapati
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Anticancer Effects ◽  
Mcf 7

scholarly journals Analysis and Anticancer Effects of Active Compounds from Spatholobi Caulis in Human Breast Cancer Cells

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1193
Author(s):  
Hung Manh Phung ◽  
Hesol Lee ◽  
Sullim Lee ◽  
Dongyeop Jang ◽  
Chang-Eop Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Gallic Acid ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Mitogen Activated Protein Kinase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Anticancer Effects ◽  
Mcf 7

Breast cancer is the most common malignancy in both developing and developed countries. In this study, we simultaneously analyzed nine constituent compounds from Spatholobi Caulis (gallic acid, (−)-gallocatechin, 3,4-dihydroxybenzoic acid, procyanidin B1, 3,4-dihydroxybenzaldehyde, catechin, procyanidin B2, epicatechin, and (−)-epicatechin gallate) and examined their anticancer effects on MCF-7 and MDA-MB-231 human breast cancer cells. The experimental results indicated that the gallic acid showed the strongest cytotoxic effect on MCF-7 cells among tested compounds whilst most of samples did not express inhibitory effect on viability of MDA-MB-231 cells, except for 70% ethanol extract of S. Caulis. Thus, gallic acid was chosen to extend anticancer mechanism study on MCF-7 cells. Our data showed that the gallic acid induced apoptotic MCF-7 cell death through both extrinsic and intrinsic pathways, which increased the expression of cleaved caspase-7, -8, and -9, Bax and p53, but reduced the expression of Bcl-2 and poly (ADP-ribose) polymerase (PARP). In addition, the network pharmacological analysis pointed out that the p53, mitogen-activated protein kinase (MAPK), estrogen, and Wnt signaling pathways have a great correlation with the targets of gallic acid. This study suggested that gallic acid is a bioactive component of S. Caulis with potential to be used in chemotherapy for breast cancer.

scholarly journals Arsenic hexoxide enhances TNF-α-induced anticancer effects by inhibiting NF-κB activity at a safe dose in MCF-7 human breast cancer cells

2014 ◽  
Vol 31 (5) ◽  
pp. 2305-2311 ◽  
Author(s):  
MIN JEONG KIM ◽  
JI HYUN JUNG ◽  
WON SUP LEE ◽  
JEONG WON YUN ◽  
JING NAN LU ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Anticancer Effects ◽  
Tnf Α ◽  
Safe Dose ◽  
Mcf 7
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