scholarly journals Folic acid receptor-targeted human serum albumin nanoparticle formulation of cabazitaxel for tumor therapy

2018 ◽  
Vol Volume 14 ◽  
pp. 135-148 ◽  
Author(s):  
Yating Sun ◽  
Yarong Zhao ◽  
Shanshan Teng ◽  
Fei Hao ◽  
Huan Zhang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Therapy ◽  
Acid Receptor ◽  
Nanoparticle Formulation ◽  
Folic Acid Receptor

Bioengineered Human Serum Albumin Fusion Protein as Target/Enzyme/pH Three-Stage Propulsive Drug Vehicle for Tumor Therapy

ACS Nano ◽  
2020 ◽  
Vol 14 (12) ◽  
pp. 17405-17418
Author(s):  
Mingyu Wang ◽  
Li Zhang ◽  
Yanfei Cai ◽  
Yang Yang ◽  
Lipeng Qiu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Therapy ◽  
Drug Vehicle ◽  
Target Enzyme

Insight into the interaction of human serum albumin with folic acid: A biophysical study

2018 ◽  
Vol 204 ◽  
pp. 648-656 ◽  
Author(s):  
Claudia G. Chilom ◽  
Mihaela Bacalum ◽  
Mirela M. Stanescu ◽  
Monica Florescu
Keyword(s):  
Folic Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Biophysical Study ◽  
Insight Into

scholarly journals A chromatographic approach to development of 5-aminosalicylate/folic acid fixed-dose combinations for treatment of Crohn’s disease and ulcerative colitis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mario-Livio Jeličić ◽  
Edvin Brusač ◽  
Daniela Amidžić Klarić ◽  
Biljana Nigović ◽  
Nikša Turk ◽  
...  
Keyword(s):  
Folic Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Fixed Dose ◽  
Disease Therapy ◽  
Inflammatory Bowel ◽  
Binding Percentage ◽  
States Pharmacopeia

AbstractMedication adherence is an important factor in inflammatory bowel disease therapy, which includes regular supplementation of malabsorbed vitamins. Absorption of folic acid is limited due to the damaging of the gastrointestinal tract, which can increase the chances to develop megaloblastic anaemia and colorectal cancer. In this work, 5-aminosalicylates (mesalazine, balsalazide, sulfasalazine and olsalazine) and folic acid were characterized regarding their pharmacokinetic related properties (hydrophobicity, phospholipid and plasma protein binding) using the biomimetic chromatographic approach. Despite the high binding percentage of 5-aminosalicylates for human serum albumin (> 61.44%), results have shown that folic acid binding to human serum albumin protein is far greater (69.40%) compared to α1-acid-glycoprotein (3.45%). Frontal analysis and zonal elution studies were conducted to provide an insight into the binding of folic acid to human serum albumin and potential competition with 5-aminosalicylates. The analytical method for the simultaneous determination of assay in proposed fixed-dose combinations was developed and validated according to ICH Q2 (R1) and FDA method validation guidelines. Separation of all compounds was achieved within 16 min with satisfactory resolution (Rs > 3.67) using the XBridge Phenyl column (150 × 4.6 mm, 3.5 µm). High linearity (r > 0.9997) and precision (RSD < 2.29%) was obtained, whilst all recoveries were within the regulatory defined range by British (100.0 ± 5.0%) and United States Pharmacopeia (100.0 ± 10.0%).

Doxorubicin and Fe3O4 loaded albumin nanoparticles with folic acid modified dextran surface for tumor diagnosis and therapy

2014 ◽  
Vol 2 (45) ◽  
pp. 7978-7987 ◽  
Author(s):  
Hequn Hao ◽  
Qingming Ma ◽  
Fen He ◽  
Ping Yao
Keyword(s):  
Folic Acid ◽  
Tumor Therapy ◽  
Tumor Diagnosis ◽  
Acid Receptor ◽  
Albumin Nanoparticles ◽  
Diagnosis And Therapy ◽  
Folic Acid Receptor

Doxorubicin loaded albumin nanoparticles with folic acid receptor-targeted and magnetically-guided functions significantly improve tumor therapy and MRI.

scholarly journals Folic acid-functionalized human serum albumin nanocapsules for targeted drug delivery to chronically activated macrophages

2012 ◽  
Vol 427 (2) ◽  
pp. 460-466 ◽  
Author(s):  
Alexandra Rollett ◽  
Tamara Reiter ◽  
Patricia Nogueira ◽  
Massimiliano Cardinale ◽  
Ana Loureiro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Targeted Drug Delivery ◽  
Activated Macrophages ◽  
Targeted Drug
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