scholarly journals Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

2018 ◽  
Vol Volume 14 ◽  
pp. 57-74 ◽  
Author(s):  
Yang Chen ◽  
Wei Liu ◽  
Yue Shang ◽  
Peipei Cao ◽  
Jianlin Cui ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Photodynamic Therapy ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Metal Organic Frameworks ◽  
Dual Modality ◽  
Metal Organic ◽  
Dual Modality Imaging

Theranostic micelles based on upconversion nanoparticles for dual-modality imaging and photodynamic therapy in hepatocellular carcinoma

Nanoscale ◽  
2018 ◽  
Vol 10 (14) ◽  
pp. 6511-6523 ◽  
Author(s):  
Yong Han ◽  
Yanli An ◽  
Gang Jia ◽  
Xihui Wang ◽  
Chen He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Photodynamic Therapy ◽  
Therapeutic Strategies ◽  
Upconversion Nanoparticles ◽  
Curative Surgery ◽  
Dual Modality ◽  
Dual Modality Imaging

Hepatocellular carcinoma (HCC) is frequently metastatic once diagnosed and less likely to respond to curative surgery, emphasizing the need for the development of more sensitive and effective diagnostic and therapeutic strategies.

Preparation of Gd-Au Dendrimer-Entrapped Gold Nanoparticles-Folic Acid Nanoparticles and Its Application in Computed Tomography/Magnetic Resonance Imaging Dual-Modality Diagnosis of Abdominal Tumors

2021 ◽  
Vol 13 (7) ◽  
pp. 1364-1373
Author(s):  
Yumei Zhang ◽  
Ruina Pei ◽  
Tao Luo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Receptor Expression ◽  
Average Particle ◽  
Resonance Imaging ◽  
Dual Modality ◽  
Abdominal Tumors

ABSTRACTThe development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2 oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution. When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression. During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body and further used for the early diagnosis of abdominal tumors.

scholarly journals The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

2018 ◽  
Vol 9 ◽  
pp. 2960-2967 ◽  
Author(s):  
Jan Hynek ◽  
Sebastian Jurík ◽  
Martina Koncošová ◽  
Jaroslav Zelenka ◽  
Ivana Křížová ◽  
...  
Keyword(s):  
Inorganic Chemistry ◽  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Biological Applications ◽  
Nanoparticle Surface ◽  
Metal Organic ◽  
Unsaturated Metal Sites ◽  
First Time

Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin. The nanoICR-2/porphyrin composites retain part of the free porphyrins photophysical properties, while the photodynamic efficacy is strongly affected by the R substituent at the porphyrin phosphinate groups. Thus, phosphinatophenylporphyrin with phenyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake.

scholarly journals Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy

Theranostics ◽  
2018 ◽  
Vol 8 (16) ◽  
pp. 4332-4344 ◽  
Author(s):  
Hong-Min Meng ◽  
Xiao-Xiao Hu ◽  
Ge-Zhi Kong ◽  
Chan Yang ◽  
Ting Fu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Targeted Photodynamic Therapy
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