scholarly journals Synthesis and study of cell-penetrating peptide-modified gold nanoparticles

2018 ◽  
Vol Volume 13 ◽  
pp. 6199-6205 ◽  
Author(s):  
Félix Boussoufi ◽  
Sandra Navarro Gallón ◽  
Run Chang ◽  
Thomas Webster
Keyword(s):  
Gold Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals Synthesis and Study of Cell-Penetrating Peptide-Modified Gold Nanoparticles [Corrigendum]

2021 ◽  
Vol Volume 16 ◽  
pp. 4177-4178
Author(s):  
Félix Boussoufi ◽  
Sandra Navarro Gallón ◽  
Run Chang ◽  
Thomas Webster
Keyword(s):  
Gold Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Cell-Penetrating Peptide-Modified Gold Nanoparticles for the Delivery of Doxorubicin to Brain Metastatic Breast Cancer

2016 ◽  
Vol 13 (6) ◽  
pp. 1843-1854 ◽  
Author(s):  
Ramin A. Morshed ◽  
Megan E. Muroski ◽  
Qing Dai ◽  
Michelle L. Wegscheid ◽  
Brenda Auffinger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Insights into cell penetrating peptide conjugated gold nanoparticles for internalization into bacterial cells

2018 ◽  
Vol 237 ◽  
pp. 38-46 ◽  
Author(s):  
Munish Kumar ◽  
Werner Tegge ◽  
Nishima Wangoo ◽  
Rahul Jain ◽  
Rohit K. Sharma
Keyword(s):  
Gold Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Bacterial Cells ◽  
Cell Penetrating

scholarly journals Synthesis and Enhanced Cellular Uptake In Vitro of Anti-HER2 Multifunctional Gold Nanoparticles

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 870 ◽  
Author(s):  
Cruz ◽  
Kayser
Keyword(s):  
Gold Nanoparticles ◽  
Cellular Uptake ◽  
Therapeutic Index ◽  
Active Targeting ◽  
Cell Penetrating Peptide ◽  
Antibody Drug Conjugate ◽  
Drug Conjugates ◽  
Cell Penetrating ◽  
Antibody Drug

Nanoparticle carriers offer the possibility of enhanced delivery of therapeutic payloads in tumor tissues due to tumor-selective accumulation through the enhanced permeability and retention effect (EPR). Gold nanoparticles (AuNP), in particular, possess highly appealing features for development as nanomedicines, such as biocompatibility, tunable optical properties and a remarkable ease of surface functionalization. Taking advantage of the latter, several strategies have been designed to increase treatment specificity of gold nanocarriers by attaching monoclonal antibodies on the surface, as a way to promote selective interactions with the targeted cells—an approach referred to as active-targeting. Here, we describe the synthesis of spherical gold nanoparticles surface-functionalized with an anti-HER2 antibody-drug conjugate (ADC) as an active targeting agent that carries a cytotoxic payload. In addition, we enhanced the intracellular delivery properties of the carrier by attaching a cell penetrating peptide to the active-targeted nanoparticles. We demonstrate that the antibody retains high receptor-affinity after the structural modifications performed for drug-conjugation and nanoparticle attachment. Furthermore, we show that antibody attachment increases cellular uptake in HER2 amplified cell lines selectively, and incorporation of the cell penetrating peptide leads to a further increase in cellular internalization. Nanoparticle-bound antibody-drug conjugates retain high antimitotic potency, which could contribute to a higher therapeutic index in high EPR tumors.

scholarly journals Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity

2020 ◽  
Vol 1 (2) ◽  
pp. 100014 ◽  
Author(s):  
Anja Henning-Knechtel ◽  
Sunil Kumar ◽  
Cecilia Wallin ◽  
Sylwia Król ◽  
Sebastian K.T.S. Wärmländer ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Peptide Inhibitors ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating
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