scholarly journals The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline

2011 ◽  
pp. 143 ◽  
Author(s):  
Kamal Amin ◽  
Khalid S Hashem ◽  
Kamal Amin
Keyword(s):  
Oxidative Damage ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Protective Effects

scholarly journals Cerium Oxide Nanoparticles Decrease Drought-Induced Oxidative Damage in Sorghum Leading to Higher Photosynthesis and Grain Yield

ACS Omega ◽  
2018 ◽  
Vol 3 (10) ◽  
pp. 14406-14416 ◽  
Author(s):  
Maduraimuthu Djanaguiraman ◽  
Remya Nair ◽  
Juan Pablo Giraldo ◽  
Pagadala Venkata Vara Prasad
Keyword(s):  
Oxidative Damage ◽  
Grain Yield ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Cerium oxide nanoparticles protect primary osteoblasts against hydrogen peroxide induced oxidative damage

2014 ◽  
Vol 9 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Guoqiang Zhou ◽  
Yang Li ◽  
Baofeng Zheng ◽  
Wenying Wang ◽  
Jing Gao ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Primary Osteoblasts

scholarly journals Protective Effects of Cerium Oxide Nanoparticles on MC3T3-E1 Osteoblastic Cells Exposed to X-Ray Irradiation

2016 ◽  
Vol 38 (4) ◽  
pp. 1510-1519 ◽  
Author(s):  
Cuifen Wang ◽  
Eric Blough ◽  
Xiaoniu Dai ◽  
Omolola Olajide ◽  
Henry Driscoll ◽  
...  
Keyword(s):  
Cell Viability ◽  
Cerium Oxide ◽  
Molecular Mechanisms ◽  
Ceo2 Nanoparticles ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Protective Effects ◽  
X Rays ◽  
Effective Prevention ◽  
X Ray

Background/Aims: Exposure to ionizing radiation can result in bone damage, including decreased osteocyte number and suppressed osteoblastic activity. However, molecular mechanisms remain to be elucidated, and effective prevention strategies are still limited. This study was to investigate whether cerium oxide nanoparticles (CeO2 NP) can protect MC3T3-E1 osteoblast-like cells from damaging effects of X-ray irradiation, and to study the underpinning mechanism(s). Methods: MC3T3-E1, a osteoblast-like cell line, was exposed to X-ray irradiation and treated with different concentration of CeO2 nanoparticles. The micronucleus frequency was counted under a fluorescence microscope. Cell viability was evaluated using MTT assay. The effects of irradiation and CeO2 nanoparticles on alkaline phosphatase activity and MC3T3-E1 mineralization were further assayed. Results: We found that the ratio of micronuclei to binuclei was dose-dependently increased with X-ray irradiation (from 2 to 6 Gy), but diminished with the increased concentration of CeO2 NP treatment (from 50 to 100 nM). Exposure to X-rays (6 Gy) decreased cell viability, differentiation and the mineralization, but CeO2 NP treatment (100 nM) attenuated the deteriorative effects of irradiation. Both intracellular reactive oxygen species (ROS) production and extracellular H2O2 concentration were increased after X-ray irradiation, but reduced following CeO2 NP treatment. Similar to irradiation, exposure to H2O2 (10 µM) elevated the frequency of micronuclei and diminished cell viability and mineralization, while these changes were ameliorated following CeO2 NP treatment. Conclusions: Taken together, our findings suggest that CeO2 nanoparticles exhibit astonishing protective effects on irradiation-induced osteoradionecrosis in MC3T3-E1 cells, and the protective effects appear to be mediated, at least partially, by reducing oxidative stress.

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