scholarly journals Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy

2018 ◽  
Vol Volume 13 ◽  
pp. 857-875 ◽  
Author(s):  
Fen Wang ◽  
Jia-Dong Pang ◽  
Lei-Lei Huang ◽  
Ran Wang ◽  
Dan Li ◽  
...  
Keyword(s):  
Polysaccharide Derivative

Self-assembled conjugated polymer/carboxymethyl chitosan grafted poly(p-dioxanone) nanomicelles and their use in functionalized indicator paper for fast and visual detection of a banned food dye

2014 ◽  
Vol 5 (14) ◽  
pp. 4251-4258 ◽  
Author(s):  
Hui Chen ◽  
Meiwan Chen ◽  
Xiaohui Wang ◽  
Runcang Sun
Keyword(s):  
Conjugated Polymer ◽  
Visual Detection ◽  
Aqueous Media ◽  
Carboxymethyl Chitosan ◽  
Fluorescent Nanoparticles ◽  
Selective Detection ◽  
Food Dye ◽  
Self Assembled ◽  
Polysaccharide Derivative

Fluorescent nanoparticles composed of a self-assembled polysaccharide derivative and a conjugated polymer show greatly improved sensitivity for the selective detection of a banned food dye in aqueous media.

scholarly journals Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 21 ◽  
Author(s):  
Jie-Fen Cui ◽  
Han Ye ◽  
Yu-Jie Zhu ◽  
Yin-Ping Li ◽  
Jing-Feng Wang ◽  
...  
Keyword(s):  
Glycogen Synthase ◽  
Lethal Dose ◽  
Insulin Receptors ◽  
Sulfated Polysaccharide ◽  
Phosphatidylinositol 3 Kinase ◽  
Pharmaceutical Development ◽  
Hypoglycemic Agent ◽  
Gsk 3Β ◽  
Polysaccharide Derivative

Polysaccharide chromium (III) derivatives are gaining increasing attention in improving type 2 diabetes. In this study, the sulfated polysaccharide from Enteromorpha prolifera (SPE) with 4.8 kDa was prepared by specific enzymatic hydrolysis. The obtained SPE was used to prepare a rhamnan-type sulfated polysaccharide derivative (SPED). Results indicated that O-H, C=O, and S=O were effectively involved in the chelation of SPED (chromium content 20.26%). Acute (half lethal dose > 2.38 g/kg) and sub-acute toxicity showed that SPED had no damaging effects on mice. Anti-diabetic experiment demonstrated that SPED improved glucose metabolism. Moreover, SPED promoted the PI3K/PKB/GSK-3β signaling pathway by regulating mRNA expression of insulin receptors (IR), insulin receptor substrate 2 (IRS-2), phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB), and glycogen synthase kinase 3β (GSK-3β). In conclusion, the SPED might represent a novel marine-derived candidate against hyperglycemia, which may undergo further pharmaceutical development as a hypoglycemic agent.

Inhibition of osteosarcoma growth and metastasis using a polysaccharide derivative of Amy-g-PLLD for the delivery of AEG-1 siRNA

Nano Research ◽  
2018 ◽  
Vol 11 (7) ◽  
pp. 3886-3898
Author(s):  
Fen Wang ◽  
Jiadong Pang ◽  
Leilei Huang ◽  
Ran Wang ◽  
Qing Jiang ◽  
...  
Keyword(s):  
Polysaccharide Derivative

scholarly journals α-1,3-Glucan benzoate – A novel polysaccharide derivative

2020 ◽  
Vol 3 (2) ◽  
pp. 71-76 ◽  
Author(s):  
Martin Gericke ◽  
Antje Tied ◽  
Christian Lenges ◽  
Thomas Heinze
Keyword(s):  
Polysaccharide Derivative

scholarly journals Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/ reperfusion injury

2009 ◽  
Vol 102 (11) ◽  
pp. 837-845 ◽  
Author(s):  
Sara Castiglia ◽  
Marco Manoni ◽  
Liana Salsini ◽  
Jacopo Chini ◽  
Emanuela Masini ◽  
...  
Keyword(s):  
Infarct Size ◽  
Rat Model ◽  
Infarct Volume ◽  
Anticoagulant Activity ◽  
Intercellular Adhesion Molecule ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Polysaccharide Derivative ◽  
The Brain ◽  
K5 Polysaccharide

SummaryHeparin and low molecular weight heparins may reduce brain damage evoked by ischaemia/reperfusion (I/R) injury, although their use is hampered by the risk of haemorrhage. Chemical and enzymatic modifications of K5 polysaccharide have shown the possibility to produce heparin-like compounds with low anticoagulant activity and strong anti-inflammatory effects. Using a rat model of transient cerebral I/R, we investigated the effects of an epimerised N-,O-sulfated K5 polysaccharide derivative, K5-N,OSepi, on the infarct size, motor activity and injury caused by ischaemia (30 min) and reperfusion. Reperfusion was allowed for 60 min or 1–5 days. Rats reperfused for 5 days showed an infarct volume of 30.7 ±3.1% and K5-N,OSepi (0.1–1 mg/kg) caused dose-dependent reduction in infarct size (maximum at 1 mg/kg: 13.1 ±2.1% infarct volume). This effect was associated with a significant improvement in motor performance. In the rat hippocampus, one of the brain areas most sensitive to I/R injury, I/R induced a robust increase in myeloperoxidase (MPO) activity, a marker of neutrophil infiltration, that was halved by K5-N,OSepi administration (66.38 ±7.75 µU MPO/tissue g, 30.78 ±5.67 µU MPO/tissue g, respectively). K5-N,OSepi drastically reduced the expression of cyclooxygenase-2,inducible-nitric-oxide-synthase and intercellular-adhesion-molecule-1. I/R-induced activation of nuclear factor-kB was attenuated by drug treatment. Furthermore, K5-N,OSepi administration was associated with a significant modulation of apoptosis markers, such as Bid and Bcl-2. In conclusion, the results demonstrated that the sulfated semi-synthetic K5 derivative K5-N,OSepi protects the brain against I/R injury by disrupting multiple levels of the apoptotic and inflammatory cascade, including inhibition of NF-κB activation.

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