scholarly journals Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release

2017 ◽  
Vol Volume 12 ◽  
pp. 6857-6870 ◽  
Author(s):  
Quan Chen ◽  
Siheng Li ◽  
Zixiong Feng ◽  
Meng Wang ◽  
Chengzhi Cai ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Mixed Micelles ◽  
Control Release ◽  
Drug Control ◽  
Ph Responsive ◽  
Ethyl Methacrylate

Biomineralization inspired synthesis of CaCO3-based DDS for pH-responsive release of anticancer drug

2021 ◽  
pp. 102256
Author(s):  
Tingyu Yang ◽  
Yangyang Ao ◽  
Juanjuan Feng ◽  
Cuiyan Wang ◽  
Jianbin Zhang
Keyword(s):  
Anticancer Drug ◽  
Ph Responsive

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery

2017 ◽  
Vol 60 ◽  
pp. 244-255 ◽  
Author(s):  
Jiao Guan ◽  
Zun-Qiang Zhou ◽  
Mao-Hua Chen ◽  
Hui-Yan Li ◽  
Da-Nian Tong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Target Cell ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Anticancer Drug Delivery

Magnetic- and pH-responsive κ-carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug

2017 ◽  
Vol 97 ◽  
pp. 209-217 ◽  
Author(s):  
Gholam Reza Mahdavinia ◽  
Amirabbas Mosallanezhad ◽  
Moslem Soleymani ◽  
Mohammad Sabzi
Keyword(s):  
Controlled Release ◽  
Anticancer Drug ◽  
Ph Responsive

Magnetic and pH responsive composite hydrogel-based on poly(2-(diethylamino)ethyl methacrylate)/chitosan for fipronil removal from aqueous medium

2021 ◽  
Vol 168 ◽  
pp. 105050
Author(s):  
Marcella Matos Cordeiro Borges ◽  
Bruna Carneiro Pires ◽  
Sara Silveira Vieira ◽  
Keyller Bastos Borges ◽  
Luiz Gustavo de Lima Guimarães
Keyword(s):  
Aqueous Medium ◽  
Composite Hydrogel ◽  
Ph Responsive ◽  
Ethyl Methacrylate
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