scholarly journals Graphene oxide and reduced graphene oxide induced neural pheochromocytoma-derived PC12 cell lines apoptosis and cell cycle alterations via the ERK signaling pathways

2017 ◽  
Vol Volume 12 ◽  
pp. 5501-5510 ◽  
Author(s):  
Yiyuan Kang ◽  
Jia Liu ◽  
Junrong Wu ◽  
Qian Yin ◽  
Huimin Liang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Graphene Oxide ◽  
Signaling Pathways ◽  
Reduced Graphene Oxide ◽  
Cell Lines ◽  
Pc12 Cell ◽  
Erk Signaling ◽  
Reduced Graphene ◽  
Cell Cycle Alterations

scholarly journals The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines

2021 ◽  
Vol 22 (22) ◽  
pp. 12593
Author(s):  
Rafał Krętowski ◽  
Agata Jabłońska-Trypuć ◽  
Marzanna Cechowska-Pasko
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Reduced Graphene Oxide ◽  
Cell Lines ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Breast Cancer Cell Lines ◽  
Reduced Graphene

Breast cancer is the most common cancer diagnosed in women, however traditional therapies have several side effects. This has led to an urgent need to explore novel drug approaches to treatment strategies such as graphene-based nanomaterials such as reduced graphene oxide (rGO). It was noticed as a potential drug due to its target selectivity, easy functionalisation, chemisensitisation, and high drug-loading capacity. rGO is widely used in many fields, including biological and biomedical, due to its unique physicochemical properties. However, the possible mechanisms of rGO toxicity remain unclear. In this paper, we present findings on the cytotoxic and antiproliferative effects of rGO and its ability to induce oxidative stress and apoptosis of breast cancer cell lines. We indicate that rGO induced time- and dose-dependent cytotoxicity in MDA-MB-231 and ZR-75-1 cell lines, but not in T-47D, MCF-7, Hs 578T cell lines. In rGO-treated MDA-MB-231 and ZR-75-1 cell lines, we noticed increased induction of apoptosis and necrosis. In addition, rGO has been found to cause oxidative stress, reduce proliferation, and induce structural changes in breast cancer cells. Taken together, these studies provide new insight into the mechanism of oxidative stress and apoptosis in breast cancer cells.

High Toughness Inorganic Solid Electrolytes via the Use of Reduced Graphene-Oxide

2020 ◽  
Author(s):  
Christos E. Athanasiou ◽  
Mok Yun Jin ◽  
Cristina Ramirez ◽  
Nitin P. Padture ◽  
Brian W. Sheldon
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Solid Electrolytes ◽  
High Toughness ◽  
Reduced Graphene
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