scholarly journals Enhanced antitumor activity of surface-modified iron oxide nanoparticles and an α-tocopherol derivative in a rat model of mammary gland carcinosarcoma

2017 ◽  
Vol Volume 12 ◽  
pp. 4257-4268 ◽  
Author(s):  
Daniel Horák ◽  
Vitaliy Pustovyy ◽  
Andrii Babinskyi ◽  
Olga Mikhailovna Palyvoda ◽  
Vasyl Fedorovich Chekhun ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Iron Oxide ◽  
Antitumor Activity ◽  
Iron Oxide Nanoparticles ◽  
Rat Model ◽  
Alpha Tocopherol ◽  
Oxide Nanoparticles ◽  
Surface Modified

Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

2020 ◽  
Vol 10 (2) ◽  
pp. 166-174
Author(s):  
Mehdi Khoshneviszadeh ◽  
Sarah Zargarnezhad ◽  
Younes Ghasemi ◽  
Ahmad Gholami
Keyword(s):  
Iron Oxide ◽  
Amino Acid ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Surface Charges ◽  
Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

Colloidally stable surface-modified iron oxide nanoparticles: Preparation, characterization and anti-tumor activity

2015 ◽  
Vol 380 ◽  
pp. 125-131 ◽  
Author(s):  
Hana Macková ◽  
Daniel Horák ◽  
Georgiy Viktorovich Donchenko ◽  
Vadim Ivanovich Andriyaka ◽  
Olga Mikhailovna Palyvoda ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Stable Surface ◽  
Surface Modified ◽  
Anti Tumor Activity
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