scholarly journals Inhibition of gap junction intercellular communication is involved in silica nanoparticles-induced H9c2 cardiomyocytes apoptosis via the mitochondrial pathway

2017 ◽  
Vol Volume 12 ◽  
pp. 2179-2188 ◽  
Author(s):  
Zhongjun Du ◽  
Guanqun Cui ◽  
Juan Zhang ◽  
Xiaomei Liu ◽  
Zhihu Zhang ◽  
...  
Keyword(s):  
Gap Junction ◽  
Silica Nanoparticles ◽  
Intercellular Communication ◽  
Mitochondrial Pathway ◽  
Gap Junction Intercellular Communication ◽  
H9c2 Cardiomyocytes

Connexin expression by alveolar epithelial cells is regulated by extracellular matrix

2001 ◽  
Vol 280 (2) ◽  
pp. L191-L202 ◽  
Author(s):  
Yihe Guo ◽  
Cara Martinez-Williams ◽  
Clare E. Yellowley ◽  
Henry J. Donahue ◽  
D. Eugene Rannels
Keyword(s):  
Extracellular Matrix ◽  
Epithelial Cells ◽  
Gap Junction ◽  
Intercellular Communication ◽  
Translational Regulation ◽  
Alveolar Epithelial Cells ◽  
Alveolar Type ◽  
Type Ii ◽  
Gap Junction Intercellular Communication ◽  
Type Ii Cell

Extracellular matrix (ECM) proteins promote attachment, spreading, and differentiation of cultured alveolar type II epithelial cells. The present studies address the hypothesis that the ECM also regulates expression and function of gap junction proteins, connexins, in this cell population. Expression of cellular fibronectin and connexin (Cx) 43 increase in parallel during early type II cell culture as Cx26 expression declines. Gap junction intercellular communication is established over the same interval. Cells plated on a preformed, type II cell-derived, fibronectin-rich ECM demonstrate accelerated formation of gap junction plaques and elevated gap junction intercellular communication. These effects are blocked by antibodies against fibronectin, which cause redistribution of Cx43 protein from the plasma membrane to the cytoplasm. Conversely, cells cultured on a laminin-rich ECM, Matrigel, express low levels of Cx43 but high levels of Cx26, reflecting both transcriptional and translational regulation. Cx26 and Cx43 thus demonstrate reciprocal regulation by ECM constituents.

scholarly journals Simvastatin protects Sertoli cells against cisplatin cytotoxicity through enhanced gap junction intercellular communication

2015 ◽  
Vol 34 (4) ◽  
pp. 2133-2141 ◽  
Author(s):  
LINGZHI WANG ◽  
JIANXIN PENG ◽  
HUANSEN HUANG ◽  
QIN WANG ◽  
MEILING YU ◽  
...  
Keyword(s):  
Gap Junction ◽  
Intercellular Communication ◽  
Sertoli Cells ◽  
Gap Junction Intercellular Communication
Sign in / Sign up

Export Citation Format

Share Document