scholarly journals Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer

2017 ◽  
Vol Volume 12 ◽  
pp. 2129-2142 ◽  
Author(s):  
Lianru Zhang ◽  
Rutian Li ◽  
Hong Chen ◽  
Jia Wei ◽  
Hanqing Qian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Drug Targeting ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte ◽  
New Approach ◽  
Lymphocyte Membrane ◽  
Dose Irradiation

Camouflaging iRGD-EGFR anchored human cytotoxic T-lymphocyte membranes to the surface of nanoparticles combined with low-dose irradiation: New approach to enhance drug-delivery targeting in gastric cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e14076-e14076
Author(s):  
Lianru Zhang ◽  
Huizi Sha ◽  
Rutian Li ◽  
Jia Wei ◽  
Baorui Liu
Keyword(s):  
Tumor Cells ◽  
T Lymphocyte ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Membrane ◽  
Dose Irradiation ◽  
Egfr Expression ◽  
Tumor Accumulation ◽  
Accumulation Ability ◽  
Encapsulated Nanoparticles

e14076 Background: We report a biomimetic delivery platform based on human cytotoxic T-lymphocyte membranes. In this platform, T-lymphocyte membranes were camouflaged to the surface of poly-lactic-co-glycolic acid nanoparticles, with local low-dose irradiation (LDI) as a chemoattractant. These carriers were further anchored with the recombinant protein anti-EGFR-iRGD, improving tumor accumulation, facilitating tumor uptake. Methods: The T-lymphocyte membrane coating was verified by dynamic light scattering, transmission electron microscopy and confocal laser scanning microscopy. The particle phagocytosis study was performed using a human phagocytic cell line. In vivo NIR fluorescence imaging was performed to monitor the route of nanoparticles. EGFR expression of tumor cells was tested before and after LDI. Results: This new platform reduced phagocytosis of macrophages by 23.99% (p = 0.002). iRGD-EGFR anchored T-lymphocyte membrane-encapsulated nanoparticles accumulated in tumor site more than unfunctionalized groups, while LDI significantly enhanced the targeting ability. LDI could up-regulate EGFR expression on tumor cells, which was important in the process of localization of iRGD-EGFR anchored T-lymphocyte membrane-encapsulated nanoparticles in tumors. Conclusions: This new platform included both the long circulation time and tumor sites accumulation ability while LDI could significantly enhance the tumor accumulation ability.

Cytotoxic T‐lymphocyte‐associated protein 4 in gastric cancer: Prognosis and association with PD‐L1 expression

2021 ◽  
Author(s):  
Marina Alessandra Pereira ◽  
Tiago Biachi Castria ◽  
Marcus Fernando Kodama Pertille Ramos ◽  
André Roncon Dias ◽  
Leonardo Cardili ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Cancer Prognosis

scholarly journals Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin

2013 ◽  
Vol 15 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Kaoru Takabayashi ◽  
Kazuhiro Kashiwagi ◽  
Tetsuya Kawata ◽  
Toshiro Sato ◽  
Katsuyoshi Matsuoka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Low Dose ◽  
Gastric Cancer Cells ◽  
Dose Irradiation

Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis

2019 ◽  
Vol 73 (6) ◽  
pp. 318-321
Author(s):  
Zongjing Xie ◽  
Bingmei Wang ◽  
Yongjie Chai ◽  
Junyin Chen
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Meta Analysis ◽  
Interleukin 4 ◽  
East Asians ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Positive Results ◽  
Review Manager

AimsAssociations between polymorphisms in cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)/mannose-binding lectin (MBL)/interleukin-4 (IL-4)/interleukin-6 (IL-6)/phospholipase C ε−1 (PLCE1) and gastric cancer (GC) were already reported by many studies, yet the conclusions of these studies were somehow controversial. The aim of this meta-analysis was to better clarify associations between polymorphisms in CTLA-4/MBL/IL-4/IL-6/PLCE1 and GC by combing the results of all relevant studies.MethodsEligible studies were searched from PubMed, Embase, WOS and CNKI. We used Review Manager to combine the results of individual studies.ResultsForty-three studies were included in this meta-analysis. Combined results revealed that CTLA-4 rs5742909 (dominant comparison: OR: 1.58, 95 % CI: 1.01 to 2.48; allele comparison: OR: 1.69, 95 % CI: 1.12 to 2.56) and PLCE1 rs2274223 (dominant comparison: OR: 0.84, 95 % CI: 0.72 to 0.98; recessive comparison: OR: 1.23, 95 % CI: 1.08 to 1.40; over-dominant comparison: OR: 1.16, 95 % CI: 1.00 to 1.34; allele comparison: OR 0.88, 95 % CI 0.78 to 0.99) polymorphisms were significantly associated with GC in the general population. We also obtained similar significant associations with GC for rs5742909 and rs2274223 polymorphisms in East Asians. Nevertheless, no positive results were observed for the other eight investigated polymorphisms.ConclusionCollectively, this meta-analysis demonstrated that CTLA-4 rs5742909 and PLCE1 rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians.

Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer

2009 ◽  
Vol 37 (1) ◽  
pp. 515-520 ◽  
Author(s):  
Ruiping Hou ◽  
Bangwei Cao ◽  
Zhongdong Chen ◽  
Yong Li ◽  
Tao Ning ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Gene Haplotype

Presence of an enlarged pool of MOPC-315-specific cytotoxic T lymphocyte precursors in the thymuses of mice that eradicated a large MOPC-315 tumor as a consequence of low-dose melphalan therapy

1990 ◽  
Vol 32 (3) ◽  
pp. 143-153 ◽  
Author(s):  
Mary M. Bartik ◽  
Mi-Chung Ahn ◽  
Barbara A. Baumgartel ◽  
Robert L. Hendricks ◽  
Margalit B. Mokyr
Keyword(s):  
T Lymphocyte ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte
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