Presence of an enlarged pool of MOPC-315-specific cytotoxic T lymphocyte precursors in the thymuses of mice that eradicated a large MOPC-315 tumor as a consequence of low-dose melphalan therapy

1990 ◽  
Vol 32 (3) ◽  
pp. 143-153 ◽  
Author(s):  
Mary M. Bartik ◽  
Mi-Chung Ahn ◽  
Barbara A. Baumgartel ◽  
Robert L. Hendricks ◽  
Margalit B. Mokyr
Keyword(s):  
T Lymphocyte ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte

Camouflaging iRGD-EGFR anchored human cytotoxic T-lymphocyte membranes to the surface of nanoparticles combined with low-dose irradiation: New approach to enhance drug-delivery targeting in gastric cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e14076-e14076
Author(s):  
Lianru Zhang ◽  
Huizi Sha ◽  
Rutian Li ◽  
Jia Wei ◽  
Baorui Liu
Keyword(s):  
Tumor Cells ◽  
T Lymphocyte ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Membrane ◽  
Dose Irradiation ◽  
Egfr Expression ◽  
Tumor Accumulation ◽  
Accumulation Ability ◽  
Encapsulated Nanoparticles

e14076 Background: We report a biomimetic delivery platform based on human cytotoxic T-lymphocyte membranes. In this platform, T-lymphocyte membranes were camouflaged to the surface of poly-lactic-co-glycolic acid nanoparticles, with local low-dose irradiation (LDI) as a chemoattractant. These carriers were further anchored with the recombinant protein anti-EGFR-iRGD, improving tumor accumulation, facilitating tumor uptake. Methods: The T-lymphocyte membrane coating was verified by dynamic light scattering, transmission electron microscopy and confocal laser scanning microscopy. The particle phagocytosis study was performed using a human phagocytic cell line. In vivo NIR fluorescence imaging was performed to monitor the route of nanoparticles. EGFR expression of tumor cells was tested before and after LDI. Results: This new platform reduced phagocytosis of macrophages by 23.99% (p = 0.002). iRGD-EGFR anchored T-lymphocyte membrane-encapsulated nanoparticles accumulated in tumor site more than unfunctionalized groups, while LDI significantly enhanced the targeting ability. LDI could up-regulate EGFR expression on tumor cells, which was important in the process of localization of iRGD-EGFR anchored T-lymphocyte membrane-encapsulated nanoparticles in tumors. Conclusions: This new platform included both the long circulation time and tumor sites accumulation ability while LDI could significantly enhance the tumor accumulation ability.

scholarly journals Low Dose Decitabine Treatment Induces CD80 Expression in Cancer Cells and Stimulates Tumor Specific Cytotoxic T Lymphocyte Responses

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62924 ◽  
Author(s):  
Li-Xin Wang ◽  
Zhen-Yang Mei ◽  
Ji-Hao Zhou ◽  
Yu-Shi Yao ◽  
Yong-Hui Li ◽  
...  
Keyword(s):  
Cancer Cells ◽  
T Lymphocyte ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Responses

Effect of helper and/or cytotoxic T-lymphocyte depletion on low-dose streptozocin-induced diabetes in C57BL/6J mice

Diabetes ◽  
1988 ◽  
Vol 37 (8) ◽  
pp. 1082-1089 ◽  
Author(s):  
M. D. Dayer-Metroz ◽  
M. Kimoto ◽  
S. Izui ◽  
P. Vassalli ◽  
A. E. Renold
Keyword(s):  
T Lymphocyte ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Depletion

Effect of Helper and/or Cytotoxic T-Lymphocyte Depletion on Low-Dose Streptozocin-Induced Diabetes in C57BL/6J Mice

Diabetes ◽  
1988 ◽  
Vol 37 (8) ◽  
pp. 1082-1089 ◽  
Author(s):  
M.-D. Dayer-Metroz ◽  
M. Kimoto ◽  
S. Izui ◽  
P. Vassalli ◽  
A. E. Renold
Keyword(s):  
T Lymphocyte ◽  
Low Dose ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Depletion
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