scholarly journals Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster

2017 ◽  
Vol Volume 12 ◽  
pp. 1621-1637 ◽  
Author(s):  
Cheng Teng Ng ◽  
Liang Qing Yong ◽  
Manoor Prakash Hande ◽  
Choon Nam Ong ◽  
Liya Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Drosophila Melanogaster ◽  
Stress Responses ◽  
Zinc Oxide Nanoparticles ◽  
Human Lung ◽  
Lung Fibroblasts ◽  
Oxide Nanoparticles ◽  
Human Lung Fibroblasts ◽  
Oxidative Stress Responses

Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus

2020 ◽  
Vol 154 ◽  
pp. 111078 ◽  
Author(s):  
Stella W.Y. Wong ◽  
Guang-Jie Zhou ◽  
Priscilla T.Y. Leung ◽  
Jeonghoon Han ◽  
Jae-Seong Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Tigriopus Japonicus ◽  
Marine Copepod ◽  
Copepod Tigriopus Japonicus

scholarly journals The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro

Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4062
Author(s):  
Till Jasper Meyer ◽  
Agmal Scherzad ◽  
Helena Moratin ◽  
Thomas Eckert Gehrke ◽  
Julian Killisperger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxidative Dna Damage ◽  
Clonogenic Survival ◽  
Oxide Nanoparticles ◽  
Radiosensitizing Effect ◽  
Primary Fibroblasts

Radioresistance is an important cause of head and neck cancer therapy failure. Zinc oxide nanoparticles (ZnO-NP) mediate tumor-selective toxic effects. The aim of this study was to evaluate the potential for radiosensitization of ZnO-NP. The dose-dependent cytotoxicity of ZnO-NP20 nm and ZnO-NP100 nm was investigated in FaDu and primary fibroblasts (FB) by an MTT assay. The clonogenic survival assay was used to evaluate the effects of ZnO-NP alone and in combination with irradiation on FB and FaDu. A formamidopyrimidine-DNA glycosylase (FPG)-modified single-cell microgel electrophoresis (comet) assay was applied to detect oxidative DNA damage in FB as a function of ZnO-NP and irradiation exposure. A significantly increased cytotoxicity after FaDu exposure to ZnO-NP20 nm or ZnO-NP100 nm was observed in a concentration of 10 µg/mL or 1 µg/mL respectively in 30 µg/mL of ZnO-NP20 nm or 20 µg/mL of ZnO-NP100 nm in FB. The addition of 1, 5, or 10 µg/mL ZnO-NP20 nm or ZnO-NP100 nm significantly reduced the clonogenic survival of FaDu after irradiation. The sub-cytotoxic dosage of ZnO-NP100 nm increased the oxidative DNA damage compared to the irradiated control. This effect was not significant for ZnO-NP20 nm. ZnO-NP showed radiosensitizing properties in the sub-cytotoxic dosage. At least for the ZnO-NP100 nm, an increased level of oxidative stress is a possible mechanism of the radiosensitizing effect.

Acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles were prevented by vitamin C

2014 ◽  
Vol 229 ◽  
pp. S239
Author(s):  
Hiroko Fukui ◽  
Hitoshi Iwahashi ◽  
Shigehisa Endoh ◽  
Keiko Nishio ◽  
Yasukazu Yoshida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Vitamin C ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles
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