scholarly journals Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway

2016 ◽  
Vol Volume 12 ◽  
pp. 263-277 ◽  
Author(s):  
Yue Qin ◽  
Suning Li ◽  
Gan Zhao ◽  
Xuanhao Fu ◽  
Xueping Xie ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Pulmonary Fibrosis ◽  
Intravenous Administration ◽  
Nuclear Factor Kappa B ◽  
Single Walled Carbon Nanotubes ◽  
Nuclear Factor ◽  
Single Walled Carbon ◽  
Nuclear Factor Kappa ◽  
Walled Carbon Nanotubes

Long-term stem cell labeling by collagen-functionalized single-walled carbon nanotubes

Nanoscale ◽  
2014 ◽  
Vol 6 (3) ◽  
pp. 1552-1559 ◽  
Author(s):  
Hongli Mao ◽  
Rong Cai ◽  
Naoki Kawazoe ◽  
Guoping Chen
Keyword(s):  
Carbon Nanotubes ◽  
Stem Cell ◽  
Single Walled Carbon Nanotubes ◽  
Cell Labeling ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice

2008 ◽  
Vol 181 (3) ◽  
pp. 182-189 ◽  
Author(s):  
Sheng-Tao Yang ◽  
Xiang Wang ◽  
Guang Jia ◽  
Yiqun Gu ◽  
Tiancheng Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Low Toxicity ◽  
Walled Carbon Nanotubes

scholarly journals The Long-Term Fate and Toxicity of PEG-Modified Single-Walled Carbon Nanotube Isoliquiritigenin Delivery Vehicles in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Bo Han ◽  
Mingming Zhang ◽  
Ting Tang ◽  
Qiusheng Zheng ◽  
Keyu Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Molecular Weight ◽  
Single Walled Carbon Nanotubes ◽  
Blood Clearance ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Tissue Sections ◽  
Covalently Linked ◽  
Walled Carbon Nanotubes

Oxidized single-walled carbon nanotubes (o-SWNTs) was modified by covalently and noncovalently linking PEG to the o-SWNTs. The influence of oxidation time, PEG molecular weight, and type of PEG linkage on the blood clearance time of PEG-modified single-walled carbon nanotubes (SWNTs) was investigated. The toxicity profile of SWNTs covalently linked to PEG (c-PEG-o-SWNTs) in rats has also been determined. The pharmacokinetics of c-PEG-o-SWNTs in rats and their distribution in vital organs were monitored by Raman spectroscopy, and the blood clearance of homogenate isoliquiritigenin (ISL) was determined by HPLC. Photos of tissue and tissue sections were taken to evaluate the toxicity of c-PEG-o-SWNTs. We found that SWNTs which were covalently modified with PEG and have a molecular weight of 3500 had the longest blood clearance half-lives. However, SWNTs were toxic to the kidneys and the hearts. The high renal clearance of long-term fate SWNTs may occur because of impaired kidney filtration function. Therefore, we assume that while researchers study the long-term fate of SWNTs, the toxicity of SWNTs also needs to be taken into account.

The DNA hybridization assay using single-walled carbon nanotubes as ultrasensitive, long-term optical labels

2006 ◽  
Vol 17 (14) ◽  
pp. 3442-3445 ◽  
Author(s):  
Eung-Soo Hwang ◽  
Chengfan Cao ◽  
Sanghyun Hong ◽  
Hye-Jin Jung ◽  
Chang-Yong Cha ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Dna Hybridization ◽  
Single Walled Carbon Nanotubes ◽  
Hybridization Assay ◽  
Single Walled Carbon ◽  
Optical Labels ◽  
Walled Carbon Nanotubes

scholarly journals Long-Term Effects of TCM Yangqing Kangxian Formula on Bleomycin-Induced Pulmonary Fibrosis in Rats via Regulating Nuclear Factor-κB Signaling

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Meng Li ◽  
Ya Li ◽  
JianSheng Li ◽  
Peng Zhao ◽  
Yunping Bai ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor Κb ◽  
Cell Populations ◽  
Therapeutic Effects ◽  
Nuclear Factor ◽  
Long Term Effects ◽  
Treatment Groups ◽  
Nuclear Factor Kappa

Objective. We aimed to evaluate the therapeutic effects and long-term effects of YKF and dissect the potential mechanisms. Materials and Methods. IPF rats were given YKF, prednisone, or pirfenidone, respectively, from day 1 to day 42, followed by a 28-day nonintervention interval through day 70. Forced vital capacity (FVC), histopathology, hydroxyproline (HYP) contents, lung coefficient, blood inflammatory cell populations, inflammatory cytokine levels of the lung tissues, and the expression of proteins involved in nuclear factor- (NF-) κB signaling pathway were evaluated on days 7, 14, 28, 42, and 70. Results. HYP contents, Ashcroft scores, lung coefficient, and pulmonary fibrosis blood cell populations increased significantly in IPF rats, while FVC declined. All the above-mentioned parameters were improved in treatment groups from day 7 up to day 70, especially in YKF group. The mRNA and protein expressions of tumor necrosis factor- (TNF-) α significantly decreased, while interferon- (IFN-) γ significantly increased, and phosphorylations of cytoplasm inhibitor of nuclear factor kappa-B kinase β (IKKβ), inhibitor of nuclear factor kappa-B α (IκBα), and NF-κB were obviously downregulated in YKF group from day 7 to day 70. Conclusion. YKF has beneficial protective and long-term effects on pulmonary fibrosis by anti-inflammatory response and alleviating fibrosis.

scholarly journals Long-term in vivo biocompatibility of single-walled carbon nanotubes

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0226791
Author(s):  
Thomas V. Galassi ◽  
Merav Antman-Passig ◽  
Zvi Yaari ◽  
Jose Jessurun ◽  
Robert E. Schwartz ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes
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