Long-term stem cell labeling by collagen-functionalized single-walled carbon nanotubes

Nanoscale ◽  
2014 ◽  
Vol 6 (3) ◽  
pp. 1552-1559 ◽  
Author(s):  
Hongli Mao ◽  
Rong Cai ◽  
Naoki Kawazoe ◽  
Guoping Chen
Keyword(s):  
Carbon Nanotubes ◽  
Stem Cell ◽  
Single Walled Carbon Nanotubes ◽  
Cell Labeling ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice

2008 ◽  
Vol 181 (3) ◽  
pp. 182-189 ◽  
Author(s):  
Sheng-Tao Yang ◽  
Xiang Wang ◽  
Guang Jia ◽  
Yiqun Gu ◽  
Tiancheng Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Low Toxicity ◽  
Walled Carbon Nanotubes

scholarly journals The Long-Term Fate and Toxicity of PEG-Modified Single-Walled Carbon Nanotube Isoliquiritigenin Delivery Vehicles in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Bo Han ◽  
Mingming Zhang ◽  
Ting Tang ◽  
Qiusheng Zheng ◽  
Keyu Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Molecular Weight ◽  
Single Walled Carbon Nanotubes ◽  
Blood Clearance ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Tissue Sections ◽  
Covalently Linked ◽  
Walled Carbon Nanotubes

Oxidized single-walled carbon nanotubes (o-SWNTs) was modified by covalently and noncovalently linking PEG to the o-SWNTs. The influence of oxidation time, PEG molecular weight, and type of PEG linkage on the blood clearance time of PEG-modified single-walled carbon nanotubes (SWNTs) was investigated. The toxicity profile of SWNTs covalently linked to PEG (c-PEG-o-SWNTs) in rats has also been determined. The pharmacokinetics of c-PEG-o-SWNTs in rats and their distribution in vital organs were monitored by Raman spectroscopy, and the blood clearance of homogenate isoliquiritigenin (ISL) was determined by HPLC. Photos of tissue and tissue sections were taken to evaluate the toxicity of c-PEG-o-SWNTs. We found that SWNTs which were covalently modified with PEG and have a molecular weight of 3500 had the longest blood clearance half-lives. However, SWNTs were toxic to the kidneys and the hearts. The high renal clearance of long-term fate SWNTs may occur because of impaired kidney filtration function. Therefore, we assume that while researchers study the long-term fate of SWNTs, the toxicity of SWNTs also needs to be taken into account.

The DNA hybridization assay using single-walled carbon nanotubes as ultrasensitive, long-term optical labels

2006 ◽  
Vol 17 (14) ◽  
pp. 3442-3445 ◽  
Author(s):  
Eung-Soo Hwang ◽  
Chengfan Cao ◽  
Sanghyun Hong ◽  
Hye-Jin Jung ◽  
Chang-Yong Cha ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Dna Hybridization ◽  
Single Walled Carbon Nanotubes ◽  
Hybridization Assay ◽  
Single Walled Carbon ◽  
Optical Labels ◽  
Walled Carbon Nanotubes
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