scholarly journals Optical coherence tomography of the preterm eye: from retinopathy of prematurity to brain development

Eye and Brain ◽  
2016 ◽  
pp. 123 ◽  
Author(s):  
Cynthia Toth ◽  
Adam Rothman ◽  
Shwetha Mangalesh ◽  
Xi Chen
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Development ◽  
Retinopathy Of Prematurity ◽  
Optical Coherence

scholarly journals Clinical relevance of retinal structure in children with laser-treated retinopathy of prematurity versus controls - using optical coherence tomography

2017 ◽  
Vol 96 (2) ◽  
pp. e222-e228 ◽  
Author(s):  
Florina Stoica ◽  
Adela Chirita-Emandi ◽  
Nicoleta Andreescu ◽  
Alina Stanciu ◽  
Cristian G. Zimbru ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinopathy Of Prematurity ◽  
Clinical Relevance ◽  
Optical Coherence ◽  
Retinal Structure

Optical Coherence Tomography Findings in Stage 4A Retinopathy of Prematurity

Ophthalmology ◽  
2006 ◽  
Vol 113 (4) ◽  
pp. 657-660 ◽  
Author(s):  
Mandar M. Joshi ◽  
Michael T. Trese ◽  
Antonio Capone
Keyword(s):  
Optical Coherence Tomography ◽  
Retinopathy Of Prematurity ◽  
Optical Coherence

scholarly journals In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
A. H. Dur ◽  
T. Tang ◽  
S. Viviano ◽  
A. Sekuri ◽  
H. R. Willsey ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Development ◽  
Neural Cell ◽  
Optical Coherence ◽  
Csf Flow ◽  
Csf Circulation ◽  
Cell Organization ◽  
Ependymal Cilia ◽  
Oct Imaging

Abstract Background Hydrocephalus, the pathological expansion of the cerebrospinal fluid (CSF)-filled cerebral ventricles, is a common, deadly disease. In the adult, cardiac and respiratory forces are the main drivers of CSF flow within the brain ventricular system to remove waste and deliver nutrients. In contrast, the mechanics and functions of CSF circulation in the embryonic brain are poorly understood. This is primarily due to the lack of model systems and imaging technology to study these early time points. Here, we studied embryos of the vertebrate Xenopus with optical coherence tomography (OCT) imaging to investigate in vivo ventricular and neural development during the onset of CSF circulation. Methods Optical coherence tomography (OCT), a cross-sectional imaging modality, was used to study developing Xenopus tadpole brains and to dynamically detect in vivo ventricular morphology and CSF circulation in real-time, at micrometer resolution. The effects of immobilizing cilia and cardiac ablation were investigated. Results In Xenopus, using OCT imaging, we demonstrated that ventriculogenesis can be tracked throughout development until the beginning of metamorphosis. We found that during Xenopus embryogenesis, initially, CSF fills the primitive ventricular space and remains static, followed by the initiation of the cilia driven CSF circulation where ependymal cilia create a polarized CSF flow. No pulsatile flow was detected throughout these tailbud and early tadpole stages. As development progressed, despite the emergence of the choroid plexus in Xenopus, cardiac forces did not contribute to the CSF circulation, and ciliary flow remained the driver of the intercompartmental bidirectional flow as well as the near-wall flow. We finally showed that cilia driven flow is crucial for proper rostral development and regulated the spatial neural cell organization. Conclusions Our data support a paradigm in which Xenopus embryonic ventriculogenesis and rostral brain development are critically dependent on ependymal cilia-driven CSF flow currents that are generated independently of cardiac pulsatile forces. Our work suggests that the Xenopus ventricular system forms a complex cilia-driven CSF flow network which regulates neural cell organization. This work will redirect efforts to understand the molecular regulators of embryonic CSF flow by focusing attention on motile cilia rather than other forces relevant only to the adult.

Myopia and anterior segment optical coherence tomography findings in laser-treated retinopathy of prematurity eyes

2020 ◽  
Vol 24 (2) ◽  
pp. 86.e1-86.e7
Author(s):  
Tamara L. Lenis ◽  
Robert C. Gunzenhauser ◽  
Simon S.M. Fung ◽  
Yasmeen K. Dhindsa ◽  
David Sarraf ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinopathy Of Prematurity ◽  
Anterior Segment ◽  
Optical Coherence

scholarly journals Simultaneous Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Correlate Retinal Thickness Changes to Vascular Abnormalities in an In Vivo Mouse Model of Retinopathy of Prematurity

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Olachi J. Mezu-Ndubuisi ◽  
Lauren K. Taylor ◽  
Jamee A. Schoephoerster
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Retinopathy Of Prematurity ◽  
Retinal Thickness ◽  
Vascular Development ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Vascular Abnormalities ◽  
Oxygen Induced Retinopathy

Background. Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascular development (RVD) in premature infants. Fluorescein angiography (FA) has depicted phases (early, mid, late, and mature) of RVD in oxygen-induced retinopathy (OIR) mice. We sought to establish the relationship between retinal structural and vascular changes using simultaneous FA and spectral domain optical coherence tomography (SD-OCT). Method. 63 mice were exposed to 77% oxygen at postnatal day 7 (P7) for 5 days, while 63 mice remained in room air (RA). Total retinal thickness (TRT), inner retinal thickness (IRT), and outer retinal thickness (ORT) were calculated at early (P19), mid (P24), late (P32), and mature (P47) phases of RVD. Results. TRT was reduced in OIR (162.66 ± 17.75 μm, n=13) compared to RA mice at P19 (197.57 ± 3.49 μm, n=14), P24, P32, and P49 (P<0.0001). ORT was similar in RA and OIR mice at all ages (P>0.05). IRT was reduced in OIR (71.60 ± 17.14 μm) compared to RA (103.07 ± 3.47 μm) mice at P19 and all ages (P<0.0001). Conclusion. We have shown the spatial and temporal relationship between retinal structure and vascular development in OIR. Significant inner retinal thinning in OIR mice persisted despite revascularization of the capillary network; further studies will elucidate its functional implications in ROP.

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