scholarly journals Simultaneous Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Correlate Retinal Thickness Changes to Vascular Abnormalities in an In Vivo Mouse Model of Retinopathy of Prematurity

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Olachi J. Mezu-Ndubuisi ◽  
Lauren K. Taylor ◽  
Jamee A. Schoephoerster
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Retinopathy Of Prematurity ◽  
Retinal Thickness ◽  
Vascular Development ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Vascular Abnormalities ◽  
Oxygen Induced Retinopathy

Background. Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascular development (RVD) in premature infants. Fluorescein angiography (FA) has depicted phases (early, mid, late, and mature) of RVD in oxygen-induced retinopathy (OIR) mice. We sought to establish the relationship between retinal structural and vascular changes using simultaneous FA and spectral domain optical coherence tomography (SD-OCT). Method. 63 mice were exposed to 77% oxygen at postnatal day 7 (P7) for 5 days, while 63 mice remained in room air (RA). Total retinal thickness (TRT), inner retinal thickness (IRT), and outer retinal thickness (ORT) were calculated at early (P19), mid (P24), late (P32), and mature (P47) phases of RVD. Results. TRT was reduced in OIR (162.66 ± 17.75 μm, n=13) compared to RA mice at P19 (197.57 ± 3.49 μm, n=14), P24, P32, and P49 (P<0.0001). ORT was similar in RA and OIR mice at all ages (P>0.05). IRT was reduced in OIR (71.60 ± 17.14 μm) compared to RA (103.07 ± 3.47 μm) mice at P19 and all ages (P<0.0001). Conclusion. We have shown the spatial and temporal relationship between retinal structure and vascular development in OIR. Significant inner retinal thinning in OIR mice persisted despite revascularization of the capillary network; further studies will elucidate its functional implications in ROP.

scholarly journals Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

2018 ◽  
Vol 2018 ◽  
pp. 1-22 ◽  
Author(s):  
Farid Atry ◽  
Israel Jacob De La Rosa ◽  
Kevin R. Rarick ◽  
Ramin Pashaie
Keyword(s):  
Optical Coherence Tomography ◽  
Imaging System ◽  
Optical Design ◽  
Spectral Domain ◽  
Design Parameters ◽  
Optical Coherence ◽  
Custom Made ◽  
Essential Knowledge ◽  
Sd Oct

In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to develop custom-made scanners that suit specific applications. This paper aims to provide a detailed discussion on the design and development process of a typical SD-OCT scanner. The effects of multiple design parameters, for the main optical and optomechanical components, on the overall performance of the imaging system are analyzed and discussions are provided to serve as a guideline for the development of a custom SD-OCT system. While this article can be generalized for different applications, we will demonstrate the design of a SD-OCT system and representative results for in vivo brain imaging. We explain procedures to measure the axial and transversal resolutions and field of view of the system and to understand the discrepancies between the experimental and theoretical values. The specific aim of this piece is to facilitate the process of constructing custom-made SD-OCT scanners for research groups with minimum understanding of concepts in optical design and medical imaging.

In vivo imaging with high-speed full-range complex spectral domain optical coherence tomography

2005 ◽  
Author(s):  
Erich Goetzinger ◽  
Michael Pircher ◽  
Rainer A. Leitgeb ◽  
Adolf F. Fercher ◽  
Christoph K. Hitzenberger
Keyword(s):  
Optical Coherence Tomography ◽  
In Vivo Imaging ◽  
High Speed ◽  
Full Range ◽  
Spectral Domain ◽  
Optical Coherence

In Vivo Assessment of Rodent Retinal Structure Using Spectral Domain Optical Coherence Tomography

2011 ◽  
pp. 489-494 ◽  
Author(s):  
M. Dominik Fischer ◽  
Gesine Huber ◽  
Francois Paquet-Durand ◽  
Peter Humphries ◽  
T. Michael Redmond ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Retinal Structure ◽  
In Vivo Assessment

Quality and Reproducibility of Retinal Thickness Measurements in Two Spectral-Domain Optical Coherence Tomography Machines

2011 ◽  
Vol 52 (9) ◽  
pp. 6925 ◽  
Author(s):  
Ilse Krebs ◽  
Eva Smretschnig ◽  
Sarah Moussa ◽  
Werner Brannath ◽  
Irene Womastek ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Thickness ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Thickness Measurements

scholarly journals In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve

2004 ◽  
Vol 12 (3) ◽  
pp. 367 ◽  
Author(s):  
N. A. Nassif ◽  
B. Cense ◽  
B. H. Park ◽  
M. C. Pierce ◽  
S. H. Yun ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
High Resolution ◽  
Spectral Domain ◽  
Human Retina ◽  
Optical Coherence
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