scholarly journals The Association Between GC Gene Polymorphisms and Metabolic Syndrome in Chinese Rural Population: A Case–Control Study

2022 ◽  
Vol Volume 15 ◽  
pp. 165-174
Author(s):  
Tong Zhao ◽  
Dongdong Zhang ◽  
Yiming Liu ◽  
Mingming Feng ◽  
Ze Xu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Rural Population ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Gc Gene ◽  
Control Study

scholarly journals Association between Two Resistin Gene Polymorphisms and Metabolic Syndrome in Jilin, Northeast China: A Case-Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Yingli Fu ◽  
Yaqin Yu ◽  
Yanhua Wu ◽  
Yueyue You ◽  
Yangyu Zhang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
International Diabetes Federation ◽  
Case Control ◽  
Han Chinese ◽  
Jilin Province ◽  
Han Chinese Population ◽  
Control Study

Metabolic syndrome (MetS) is a significant health care problem worldwide and is characterized by increased fasting glucose and obesity. Resistin is a protein hormone produced both by adipocytes and immunocompetent cells, including those residing in adipose tissue, and is believed to modulate glucose tolerance and insulin action. This study examined the association of resistin gene polymorphisms, rs1862513 and rs3745368, and related haplotypes with the development of metabolic syndrome in a Han Chinese population. This case-control study was performed on 3792 subjects, including 1771 MetS cases and 2021 healthy controls from the Jilin province of China. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Logistic regression analysis was used to estimate the relationship between gene polymorphism and MetS. Our results showed that there were no significant associations between MetS and the genotype distributions in four kinds of inheritance models, allele frequencies, and related haplotypes of resistin gene polymorphisms rs1862513 and rs3745368 (allpvalues > 0.05). Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China.

Associations of PPAR-γ , APM1 and APOC1 gene polymorphisms with metabolic syndrome in children: A case-control study

Meta Gene ◽  
2017 ◽  
Vol 12 ◽  
pp. 104-108
Author(s):  
Kaifeng Wang ◽  
Ping Ye ◽  
Xiyu Wang ◽  
Dan Wang ◽  
Yue Wu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Ppar Γ ◽  
Apoc1 Gene ◽  
Control Study

scholarly journals Association of genetic polymorphisms in XRCC4, XRCC5, XRCC6 and XRCC7 in cervical cancer susceptibility from rural population: a hospital based case-control study

2018 ◽  
Vol 6 (7) ◽  
pp. 2453
Author(s):  
Kailas D. Datkhile ◽  
Madhavi N. Patil ◽  
Pratik P. Durgawale ◽  
Kalpita S. Korbu ◽  
Shreepad A. Joshi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Rural Population ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cancer Development ◽  
Pcr Rflp ◽  
Cervical Cancer Development ◽  
Control Study

Background: Cervical cancer is a major concern of health risk, moreover the leading cause of cancer causing deaths in women of rural India. This study was aimed to assess the risk of cervical cancer development in association with polymorphisms in XRCC4, XRCC5, XRCC6 and XRCC7 genes in rural population of south-western Maharashtra.Methods: This study included 350 cervical cancer proven cases and 400 age and sex matched controls. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze the association XRCC4, XRCC6 and XRCC7 gene polymorphisms with cervical cancer development in women of Western Maharashtra.Results: The result from our study showed that allele frequencies of selected genes were not statistically different between the groups for XRCC4, XRCC5 and XRCC6. 6721 >T allele of XRCC7 (6721G>T) (OR= 2.34; 95% CI= (2.34 (1.60-3.43); p= <0.0001) significantly increased the risk of cervical cancer.Conclusions: This study indicates that XRCC7 gene polymorphisms play a role in modifying genetic susceptibility of individuals towards cervical cancer among women from rural Maharashtra. This case-control study also revealed negative association of XRCC6 gene in cervical carcinogenesis in the rural Indian population.

Lack of association between LXRα and LXRβ gene polymorphisms and prevalence of metabolic syndrome: A case–control study of an Iranian population

Gene ◽  
2013 ◽  
Vol 532 (2) ◽  
pp. 288-293 ◽  
Author(s):  
Hassan Rooki ◽  
Manjid Ghayour-Mobarhan ◽  
Monir-sadat Haerian ◽  
Mahmoud Ebrahimi ◽  
Pedram Azimzadeh ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Iranian Population ◽  
Control Study

scholarly journals Genetic association of TOLLIP gene polymorphisms and HIV infection: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ming-Gui Wang ◽  
Jing Wang ◽  
Jian-Qing He
Keyword(s):  
Hiv Infection ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Binary Logistic Regression ◽  
Case Control ◽  
Additive Models ◽  
Chinese Han ◽  
Interacting Protein ◽  
Control Study ◽  
Age And Sex

Abstract Background Previous studies have indicated that host genetic factors play an essential role in immunity to human immunodeficiency virus (HIV) infection. We aimed to investigate the association between the toll-interacting protein (TOLLIP) and mannose-binding lectin 2 (MBL2) genes and HIV infection susceptibility among Chinese Han patients. Methods This is a case-control study. A total of 435 HIV-infected patients and 1013 seronegative healthy individuals were recruited. DNA was extracted from whole blood. Two SNPs in the MBL2 gene (rs7096206 and rs1800450) and three SNPs in the TOLLIP gene (rs5743899, rs3750920, and rs5743867) were selected and genotyped using a SNPscan Kit (Cat#: G0104, Genesky Biotechnologies Inc., Shanghai, China). Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using unconditional binary logistic regression. Results A significant association between the minor alleles rs5743899 (C allele) and rs5743867 (G allele) in the TOLLIP gene and susceptibility to HIV infection was found in this study after adjusting for age and sex (Pa = 0.011 and < 0.001, respectively). The rs5743867 in the TOLLIP gene was significantly associated with the risk of HIV infection in dominant, recessive, and additive models when adjusted for age and sex (Pa < 0.05). No significant association was found between MBL2 gene polymorphisms and HIV infection. Conclusion Our study found a statistically significant association between the two SNPs (rs5743867 and rs5743899) in the TOLLIP gene and susceptibility to HIV infection in a Chinese Han population.

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