scholarly journals Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy

2020 ◽  
Vol Volume 13 ◽  
pp. 5103-5111
Author(s):  
Khalid Siddiqui ◽  
Salini Scaria Joy ◽  
Teena Puthiyaparampil George ◽  
Muhammad Mujammami ◽  
Assim A Alfadda
Keyword(s):  
Diabetic Nephropathy ◽  
Potential Role ◽  
Excretion Level

scholarly journals Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy

2019 ◽  
Vol 21 (2) ◽  
Author(s):  
David Cheng ◽  
Linbo Gao ◽  
Shan Su ◽  
Davit Sargsyan ◽  
Renyi Wu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Potential Role ◽  
Moringa Isothiocyanate

Potential Role of TGF-β in Diabetic Nephropathy

1998 ◽  
Vol 24 (2-3) ◽  
pp. 190-196 ◽  
Author(s):  
Brenda B. Hoffman ◽  
Kumar Sharma ◽  
Fuad N. Ziyadeh
Keyword(s):  
Diabetic Nephropathy ◽  
Potential Role

scholarly journals Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy

Endocrine ◽  
2008 ◽  
Vol 35 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Kathryn M. Thrailkill ◽  
R. Clay Bunn ◽  
John L. Fowlkes
Keyword(s):  
Diabetic Nephropathy ◽  
Matrix Metalloproteinases ◽  
Potential Role

scholarly journals Diagnostic value of cystatin c urine level as an early marker of diabetic nephropathy in children with type 1 diabetes mellitus

2013 ◽  
Vol 94 (2) ◽  
pp. 186-189
Author(s):  
A S Senatorova ◽  
E G Muratova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Type 1 Diabetes Mellitus ◽  
Cystatin C ◽  
Urine Excretion ◽  
Group 3 ◽  
Group 2 ◽  
Excretion Level

Aim. To improve the diagnosis of early stages of diabetic nephropathy by examining cystatin C urine excretion in children with type 1 diabetes mellitus. Methods. 83 children aged 11 to 18 years with type 1 diabetes mellitus were included in the study. Children were divided into 3 groups according to the duration of diabetes mellitus: group 1 - 1 to 2 years (n=18), group 2 - 2 to 5 years (n=24), group 3 - over 5 years (n=41). Results. The average values of glycated hemoglobin did not differ significantly between the groups and were assessed as following: group 1 - 8.61±2.1%, group 2 - 8.91±1.5%, group 3 - 8.84±2.5% (p 0,05). Development of «symptomatic» diabetic nephropathy occurred in 10% of children with type 1 diabetes with disease duration over 5 years. Cystatin C urine excretion was the highest in children with long clinical course of type 1 diabetes mellitus (p 0.01). Significant variability of cystatin C urine excretion was observed even in children with diabetes duration of 1 to 2 years. Pairwise comparison of cystatin C urine excretion levels and glycated hemoglobin values of children with type 1 diabetes did not show any statistically significant difference. Conclusion. Cystatin C urine excretion level can be an early marker of kidney damage and depict the state of tubular renal function in children with type 1 diabetes mellitus. Tubular dysfunction in children with type 1 diabetes mellitus might be diagnosed when observed cystatin C urine excretion level is over 21.9±1.4 ng/ml (sensitivity 70%, specificity 60%).

scholarly journals ANGPTL4: A Predictive Marker for Diabetic Nephropathy

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Eman Al Shawaf ◽  
Mohamed Abu-Farha ◽  
Sriraman Devarajan ◽  
Zahra Alsairafi ◽  
Irina Al-Khairi ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Diabetic Kidney Disease ◽  
Potential Role ◽  
Biochemical Marker ◽  
Predictive Marker ◽  
Control Group ◽  
Clinical Markers ◽  
Associated Proteins

Background. ANGPTL4 is a glycoprotein that is involved in regulating triglyceride metabolism by inhibiting LPL activity under fasting conditions. Additionally, ANGPTL4 has been suggested as a link between hypertriglyceridemia and albuminuria in the nephrotic syndrome. In this study, we examined levels of circulating ANGPTL4 in people with diabetic nephropathy (DN) and its association with established DN-associated proteins such as IGFBP1 and IGFBP4. Methods. We quantified circulating ANGPTL4, IGFBP1, IGFBP3, and IGFBP4 in fasting plasma samples of 122 Kuwaiti participants using a multiplexing assay. The study involved 36 controls, as well as 86 people with type 2 diabetes (T2D) including 37 people with normal kidney function and 49 people with DN. Results. ANGPTL4 level was increased in people with DN (241.56±14.1 μg/ml) compared to the control group (178.43±24.09 μg/ml). The increase in ANGPTL4 correlated with clinical parameters of DN including albumin-to-creatinine ratio (r=0.271, P=0.002), serum creatinine (r=0.381, P=0.0001), and eGFR (r=−0.349, P<0.0001). Furthermore, ANGPTL4 correlated positively with both IGFBP1 (r=0.202, P=0.026) and IGFBP4 (r=0.364, P<0.0001). Multiple regression analysis showed increased IGFBP1 and TG as predictors of higher ANGPTL4 in people with DN. In people with T2D, only IGFBP1 acted as a positive predictor of a rise in ANGPTL4. Conclusion. In this study, our data showed a significant increase in circulating ANGPTL4, IGFBP1, and IGFBP4 in patients with DN. The elevation in ANGPTL4 correlated significantly with clinical markers of DN such as ACR, serum creatinine, and eGFR, as well as IGFBP1 and IGFBP4. Altogether, this suggests a potential role for ANGPTL4 in DN perhaps through its role in inhibiting LPL activity and promotes ANGPTL4 as a biochemical marker for the detection of a diabetic kidney disease in patients with T2D.

scholarly journals Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy

2006 ◽  
Vol 69 (3) ◽  
pp. 512-519 ◽  
Author(s):  
Z.-G. Xu ◽  
S.-L. Li ◽  
L. Lanting ◽  
Y.-S. Kim ◽  
N. Shanmugam ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Potential Role ◽  
Mesangial Cells ◽  
Cox 2

scholarly journals Diabetic Nephropathy and COVID-19: The Potential Role of Immune Actors

2021 ◽  
Vol 22 (15) ◽  
pp. 7762
Author(s):  
Diane Mourad ◽  
Nadim S. Azar ◽  
Sami T. Azar
Keyword(s):  
Diabetic Nephropathy ◽  
Viral Entry ◽  
Type Ii Diabetes ◽  
Potential Role ◽  
Underlying Mechanism ◽  
Type Ii Diabetes Mellitus ◽  
Angiotensin Converting Enzyme 2 ◽  
Neuropilin 1 ◽  
Mitochondrial Glutathione

Nowadays, type II diabetes mellitus, more specifically ensuing diabetic nephropathy, and severe COVID-19 disease are known to be closely associated. The exact mechanisms behind this association are less known. An implication for the angiotensin-converting enzyme 2 remains controversial. Some researchers have started looking into other potential actors, such as neuropilin-1, mitochondrial glutathione, vitamin D, and DPP4. In particular, neuropilin-1 seems to play an important role in the underlying mechanism linking COVID-19 and diabetic nephropathy. We suggest, based on the findings in this review, that its up-regulation in the diabetic kidney facilitates viral entry in this tissue, and that the engagement of both processes leads to a depletion of neuropilin-1, which was demonstrated to be strongly associated with the pathogenesis of DN. More studies are needed to confirm this hypothesis, and research should be directed towards elucidating the potential roles of all these suggested actors and eventually discovering new therapeutic strategies that could reduce the burden of COVID-19 in patients with diabetic nephropathy.

scholarly journals LncRNA TUG1/miR-29c-3p/SIRT1 axis regulates endoplasmic reticulum stress-mediated renal epithelial cells injury in diabetic nephropathy model in vitro

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252761
Author(s):  
Shaoqiang Wang ◽  
Pengfei Yi ◽  
Na Wang ◽  
Min Song ◽  
Wenhui Li ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Epithelial Cells ◽  
Endoplasmic Reticulum Stress ◽  
High Glucose ◽  
Potential Role ◽  
Renal Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis ◽  
Lncrna Tug1

Long non-coding RNAs (lncRNAs) are important regulators in diabetic nephropathy. In this study, we investigated the potential role of lncRNA TUG1 in regulating endoplasmic reticulum stress (ERS)-mediated apoptosis in high glucose induced renal tubular epithelial cells. Human renal tubular epithelial cell line HK-2 was challenged with high glucose following transfection with lncRNA TUG1, miR-29c-3p mimics or inhibitor expression plasmid, either alone or in combination, for different experimental purposes. Potential binding effects between TUG1 and miR-29c-3p, as well as between miR-29c-3p and SIRT1 were verified. High glucose induced apoptosis and ERS in HK-2 cells, and significantly decreased TUG1 expression. Overexpressed TUG1 could prevent high glucose-induced apoptosis and alleviated ERS via negatively regulating miR-29c-3p. In contrast, miR-29c-3p increased HK-2 cells apoptosis and ERS upon high glucose-challenge. SIRT1 was a direct target gene of miR-29c-3p in HK-2 cells, which participated in the effects of miR-29c-3p on HK-2 cells. Mechanistically, TUG1 suppressed the expression of miR-29c-3p, thus counteracting its function in downregulating the level of SIRT1. TUG1 regulates miR-29c-3p/SIRT1 and subsequent ERS to relieve high glucose induced renal epithelial cells injury, and suggests a potential role for TUG1 as a promising diagnostic marker of diabetic nephropathy.

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