Potential Role of TGF-β in Diabetic Nephropathy

1998 ◽  
Vol 24 (2-3) ◽  
pp. 190-196 ◽  
Author(s):  
Brenda B. Hoffman ◽  
Kumar Sharma ◽  
Fuad N. Ziyadeh
Keyword(s):  
Diabetic Nephropathy ◽  
Potential Role

scholarly journals Diabetic Nephropathy and COVID-19: The Potential Role of Immune Actors

2021 ◽  
Vol 22 (15) ◽  
pp. 7762
Author(s):  
Diane Mourad ◽  
Nadim S. Azar ◽  
Sami T. Azar
Keyword(s):  
Diabetic Nephropathy ◽  
Viral Entry ◽  
Type Ii Diabetes ◽  
Potential Role ◽  
Underlying Mechanism ◽  
Type Ii Diabetes Mellitus ◽  
Angiotensin Converting Enzyme 2 ◽  
Neuropilin 1 ◽  
Mitochondrial Glutathione

Nowadays, type II diabetes mellitus, more specifically ensuing diabetic nephropathy, and severe COVID-19 disease are known to be closely associated. The exact mechanisms behind this association are less known. An implication for the angiotensin-converting enzyme 2 remains controversial. Some researchers have started looking into other potential actors, such as neuropilin-1, mitochondrial glutathione, vitamin D, and DPP4. In particular, neuropilin-1 seems to play an important role in the underlying mechanism linking COVID-19 and diabetic nephropathy. We suggest, based on the findings in this review, that its up-regulation in the diabetic kidney facilitates viral entry in this tissue, and that the engagement of both processes leads to a depletion of neuropilin-1, which was demonstrated to be strongly associated with the pathogenesis of DN. More studies are needed to confirm this hypothesis, and research should be directed towards elucidating the potential roles of all these suggested actors and eventually discovering new therapeutic strategies that could reduce the burden of COVID-19 in patients with diabetic nephropathy.

scholarly journals Lipotoxicity in Diabetic Nephropathy: The Potential Role of Fatty Acid Oxidation

2010 ◽  
Vol 5 (12) ◽  
pp. 2373-2379 ◽  
Author(s):  
Mariana Murea ◽  
Barry I. Freedman ◽  
John S. Parks ◽  
Peter A. Antinozzi ◽  
Steven C. Elbein ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Potential Role ◽  
Acid Oxidation

scholarly journals The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy

2020 ◽  
Vol 21 (9) ◽  
pp. 3172 ◽  
Author(s):  
Ting-Ting Chang ◽  
Jaw-Wen Chen
Keyword(s):  
Diabetic Nephropathy ◽  
End Stage Renal Disease ◽  
Chemokine Receptors ◽  
Potential Role ◽  
Chronic Inflammatory Disease ◽  
Direct Effects ◽  
Stage Renal Disease ◽  
End Stage ◽  
Kidney Function Decline

Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN.

scholarly journals Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

Diabetes ◽  
2011 ◽  
Vol 60 (11) ◽  
pp. 2954-2962 ◽  
Author(s):  
Kathrin Eller ◽  
Alexander Kirsch ◽  
Anna M. Wolf ◽  
Sieghart Sopper ◽  
Andrea Tagwerker ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
T Cells ◽  
Diabetic Nephropathy ◽  
Regulatory T Cells ◽  
Potential Role

scholarly journals The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

2022 ◽  
Vol 23 (2) ◽  
pp. 807
Author(s):  
Charlotte Delrue ◽  
Reinhart Speeckaert ◽  
Joris R. Delanghe ◽  
Marijn M. Speeckaert
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Diabetic Nephropathy ◽  
Renal Damage ◽  
Diabetic Kidney Disease ◽  
Potential Role ◽  
Genetic Mechanisms ◽  
Translational Approach ◽  
Matrix Accumulation

According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.

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