scholarly journals Increased Metabolic Burden Among Blacks: A Putative Mechanism for  Disparate COVID-19 Outcomes

2020 ◽  
Vol Volume 13 ◽  
pp. 3471-3479 ◽  
Author(s):  
Girardin Jean-Louis ◽  
Arlener D Turner ◽  
Peng Jin ◽  
Mengling Liu ◽  
Carla Boutin-Foster ◽  
...  
Keyword(s):  
Metabolic Burden ◽  
Putative Mechanism

Dimerization of the Antimicrobial Peptide Polyphemusin I into One Polypeptide Chain: Theoretical and Practical Consequences

2019 ◽  
Vol 35 (5) ◽  
pp. 36-41
Author(s):  
V.A. Zenin ◽  
E.G. Sadykhov ◽  
A.N. Fedorov
Keyword(s):  
Antimicrobial Peptides ◽  
Pore Formation ◽  
Lipid Membrane ◽  
Polypeptide Chain ◽  
Unique Identifier ◽  
Bacterial Cultures ◽  
In Series ◽  
The Russian Federation ◽  
Peptide Dimerization ◽  
Putative Mechanism

A strategy of sequential dimerization of monomers of antimicrobial peptides (AMPs) into one polypeptide chain has been implemented on the example of a beta-structural AMP polyphemusin I which is one of the most effective candidate for use as an antibiotic. The possible polyphemusin I monomer and dimer structures in lipid membrane were studied in this work via molecular modeling. To this end, these molecules were chemically synthesized so that the dimer represented two monomers connected in series into one polypeptide chain with a flexible linker. The antimicrobial effects of monomer and dimer were then tested on various bacterial cultures, and their similarity was shown. Therefore, we can conclude that the pore formation is not a putative mechanism of the polyphemusin I action. antimicrobial peptides, peptide dimerization, mechanism of antimicrobial action, polyphemusin The work was supported by the Ministry of Science and Higher Education of the Russian Federation (Project Unique Identifier RFMEFI57517X0151).

Magnesium and Hearing

2003 ◽  
Vol 14 (04) ◽  
pp. 202-212 ◽  
Author(s):  
Michael J. Cevette ◽  
Jürgen Vormann ◽  
Kay Franz
Keyword(s):  
Hair Cells ◽  
Auditory Nerve ◽  
Mg Deficiency ◽  
Noise Damage ◽  
Susceptibility To Noise ◽  
Major Progress ◽  
A Current ◽  
Putative Mechanism ◽  
Increased Susceptibility

The last several decades have revealed clinical and experimental data regarding the importance of magnesium (Mg) in hearing. Increased susceptibility to noise damage, ototoxicity, and auditory hyperexcitibility are linked to states of Mg deficiency. Evidence for these processes has come slowly and direct effects have remained elusive because plasma Mg levels do not always correlate with its deficiency. Despite the major progress in the understanding of cochlear mechanical and auditory nerve function, the neurochemical and pharmacologic role of Mg is not clear. The putative mechanism suggests that Mg deficiency may contribute to a metabolic cellular cascade of events. Mg deficiency leads to an increased permeability of the calcium channel in the hair cells with a consequent over influx of calcium, an increased release of glutamate via exocytosis, and over stimulation of NMDA receptors on the auditory nerve. This paper provides a current overview of relevant Mg metabolism and deficiency and its influence on hearing.

scholarly journals Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption

2017 ◽  
Vol 144 (2) ◽  
pp. 172-185 ◽  
Author(s):  
Rajkumar Vutukuri ◽  
Robert Brunkhorst ◽  
Roxane-Isabelle Kestner ◽  
Lena Hansen ◽  
Nerea Ferreiros Bouzas ◽  
...  
Keyword(s):  
Sphingolipid Metabolism ◽  
Putative Mechanism

Grape anthocyanin oligomerization: A putative mechanism for red color stabilization?

2014 ◽  
Vol 105 ◽  
pp. 178-185 ◽  
Author(s):  
Joana Oliveira ◽  
Natércia F. Brás ◽  
Mara Alhinho da Silva ◽  
Nuno Mateus ◽  
A. Jorge Parola ◽  
...  
Keyword(s):  
Red Color ◽  
Putative Mechanism

Mechanism of cystine reaccumulation by cystinotic fibroblasts in vitro

1990 ◽  
Vol 10 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Susan Forster ◽  
Lynne Scarlett ◽  
John B. Lloyd
Keyword(s):  
Plasma Membrane ◽  
Culture Medium ◽  
Human Fibroblasts ◽  
Competitive Inhibitor ◽  
Free Medium ◽  
Lysosome Membrane ◽  
Putative Mechanism

It is well established that when cystine-depleted cystinotic cells are cultured in cystine-containing medium, they reaccumulate cystine within their lysosomes more rapidly than when cultured in cystine-free medium. This has been a puzzling result, since the lysosome membrane of cystinotic cells is impermeable to cystine. To probe the mechanism of cystine reaccumulation, we have measured reaccumulation in the presence of colchicine, an inhibitor of pinocytosis, or of glutamate, a competitive inhibitor of cystine transport into human fibroblasts. Colchicine had no effect, thus eliminating pinocytosis as a putative mechanism for cystine translocation from the culture medium to the lysosomes. Glutamate, however, strongly inhibited cystine reaccumulation. It is concluded that the true mechanism is as follows. 1. Exogenous cystine crosses the plasma membrane on the cystine-glutamate porter. 2. Cystine is reduced in the cytoplasm by GSH. 3. The cysteine that is generated enters the lysosome, where it becomes cystine by participating in the reduction of cystine residues during intralysosomal proteolysis, or by autoxidation.

Global transcriptional analysis of metabolic burden due to plasmid maintenance in Escherichia coli DH5α during batch fermentation

2006 ◽  
Vol 39 (3) ◽  
pp. 391-398 ◽  
Author(s):  
Dave Siak-Wei Ow ◽  
Peter Morin Nissom ◽  
Robin Philp ◽  
Steve Kah-Weng Oh ◽  
Miranda Gek-Sim Yap
Keyword(s):  
Escherichia Coli ◽  
Batch Fermentation ◽  
Transcriptional Analysis ◽  
Plasmid Maintenance ◽  
Metabolic Burden

scholarly journals Perineal recurrence of prostate cancer post-brachytherapy

2019 ◽  
Vol 5 (3) ◽  
pp. 20180104
Author(s):  
Sian Cooper ◽  
Toby Pillinger ◽  
Imtiaz Ahmed ◽  
Konrad Wolfe ◽  
Sidath H Liyanage
Keyword(s):  
Prostate Cancer ◽  
Low Dose ◽  
Rare Complication ◽  
Specific Antigen ◽  
Emission Tomography ◽  
Ultrasound Guided ◽  
Low Dose Rate ◽  
Positron Emission ◽  
Putative Mechanism ◽  
Ct And Mri

We present a rare case of perineal recurrence of prostate cancer post low dose rate brachytherapy. Increased levels of prostate-specific antigen were recorded 12 years post brachytherapy. Pelvic CT and MRI visualized a nodular lesion in the perineum, and positron emission tomography demonstrated choline-avidity. Ultrasound-guided biopsy of the nodule was performed, yielding histology consistent with prostatic adenocarcinoma. Metastatic prostatic seeding to the perineum is a rare complication of brachytherapy. We discuss the putative mechanism, approach to diagnosis, and management.

Metabolic Burden and Disease and Mortality Risk Associated with Impaired Fasting Glucose in Elderly Adults

2015 ◽  
Vol 63 (7) ◽  
pp. 1435-1442 ◽  
Author(s):  
Katherine Samaras ◽  
John Crawford ◽  
Helen L. Lutgers ◽  
Lesley V. Campbell ◽  
Bernhard T. Baune ◽  
...  
Keyword(s):  
Impaired Fasting Glucose ◽  
Mortality Risk ◽  
Fasting Glucose ◽  
Elderly Adults ◽  
Metabolic Burden
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