<p>Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee</p>

Increase in mast cell marker expression in the synovium of obese patients with osteoarthritis of the knee

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s201523 ◽

2019 ◽

Vol Volume 12 ◽

pp. 377-382 ◽

Cited By ~ 2

Author(s):

Kentaro Uchida ◽

Shotaro Takano ◽

Gen Inoue ◽

Dai Iwase ◽

Jun Aikawa ◽

...

Keyword(s):

Mast Cell ◽

Osteoarthritis Of The Knee ◽

Obese Patients ◽

Cell Marker ◽

Marker Expression

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Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints.

Obesity and metabolism ◽

10.14341/omet2014441-47 ◽

2014 ◽

Vol 11 (4) ◽

pp. 41-47 ◽

Cited By ~ 3

Author(s):

Inna Vladimirovna Solov'eva ◽

Ekaterina Aleksandrovna Strebkova ◽

Lyudmila Ivanovna Alekseeva ◽

Ashot Musaelovich Mkrtumyan

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Body Weight ◽

Waist Circumference ◽

Clinical Manifestations ◽

Knee Joints ◽

Osteoarthritis Of The Knee ◽

Obese Patients ◽

Treatment Of Obesity

Obesity consistently associated with the development of a number of chronic diseases, leading to a decrease in quality of life, disability and death. The article examines the connection between obesity and disease of the musculoskeletal system, describes the mechanisms by means of which obesity leads to the development of osteoarthritis. It is evident that reduction of body mass can slow the progression of osteoporosis. The own experience of non-pharmacological and pharmacological treatment of obesity with the use of orlistat in 50 obese patients with osteoarthritis of the knee II–III stage is presented. Treatment has resulted in a decrease in body weight, waist circumference, accompanied by a decrease in symptoms osteoarthritis among all the patients. Our results showed that the addition of orlistat to standard osteoarthritis scheme leads to significant reduction in weight and reduction of clinical manifestations of osteoarthritis. According to the above, the drugs that have impact on weight loss, should be included in the treatment regimen of patients with osteoarthritis and obesity.

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Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints.

Osteoporosis and Bone Diseases ◽

10.14341/osteo12247 ◽

2017 ◽

Vol 20 (4) ◽

pp. 11-18

Author(s):

Inna Vladimirovna Solov'eva ◽

Ekaterina Aleksandrovna Strebkova ◽

Lyudmila Ivanovna Alekseeva ◽

Ashot Musaelovich Mkrtumyan

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Body Weight ◽

Clinical Manifestations ◽

Knee Joints ◽

Osteoarthritis Of The Knee ◽

Obese Patients ◽

Original Publication ◽

Treatment Of Obesity

Obesity consistently associated with the development of a number of chronic diseases, leading to a decrease in quality of life, disability and death. The article examines the connection between obesity and disease of the musculoskeletal system, describes the mechanisms by means of which obesity leads to the development of osteoarthritis. It is evident that reduction of body mass can slow the progression of osteoporosis. The own experience of non-pharmacological and pharmacological treatment of obesity with the use of orlistat in 50 obese patients with osteoarthritis of the knee IIIII stage is presented. Treatment has resulted in a decrease in body weight, waist circumference, accompanied by a decrease in symptoms osteoarthritis among all the patients. Our results showed that the addition of orlistat to standard osteoarthritis scheme leads to significant reduction in weight and reduction of clinical manifestations of osteoarthritis. According to the above, the drugs that have impact on weight loss, should be included in the treatment regimen of patients with osteoarthritis and obesity. This article is the PeReint of the original publication in Obesity and Metaboilism (2014) 11(4); pp. 41-47. doi: 10.14341/omet2014441-47

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Clinical and Radiological Outcomes of Total Knee Arthroplasty Performed with Midvastus and Medial Parapatellar Approaches in Obese Patients

Advances in Orthopedics ◽

10.1155/2021/5512930 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Olcay Guler ◽

Gürkan Gümüşsuyu ◽

Hakan Sofu ◽

Hüseyin Bahadır Gökçen

Keyword(s):

Total Knee Arthroplasty ◽

Range Of Motion ◽

Knee Arthroplasty ◽

Patient Characteristics ◽

Careful Analysis ◽

Osteoarthritis Of The Knee ◽

Obese Patients ◽

Group I ◽

Total Knee ◽

Medial Parapatellar

Background. The use of total knee arthroplasty (TKA) for primary osteoarthritis of the knee has remarkably increased recently. We aimed to compare the clinical and radiological outcomes of TKA in obese patients (>30 kg/m2) operated with midvastus (MV) or medial parapatellar (MPP) approaches. Methods. This retrospective study was performed using data derived from 80 patients (70 women; 10 men) with an average age of 66.17 ± 5.42 (range: 54 to 77). Patients were allocated into 2 groups as for the type of approach conducted during TKA: group I (n = 41) underwent TKA by MV approach, while the MMP technique was used in group II (n = 39). Results. Demographic, clinical, and radiological parameters included age, side of involvement, sex, BMI, diameters of thigh and calf, length of incision, duration of operation, amount of bleeding and transfusion, duration of hospitalization and follow-up, complications, and range of motion, as well as Knee Society Score (KSS) and Knee Society Function Score (KSFS). Patients with a higher BMI (≥35 kg/m2) experienced more profound bleeding and needed more transfusion of erythrocyte suspension. The range of motion was more favorable in groups with BMI <35 kg/m2. The functional outcomes as reflected in KSS and KSFS were much better in patients with BMI <35 kg/m2. Conclusions. Our data indicated that obesity can adversely influence the clinical and radiological outcomes after TKA performed by both MV and MPP approaches. A careful analysis of patient characteristics and selection of appropriate operative procedures is critical. Further randomized, controlled trials on larger series must be designed to elucidate the relationship between obesity and therapeutic outcomes after TKA with different approaches.

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