scholarly journals Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy

2019 ◽  
Vol Volume 12 ◽  
pp. 1811-1820 ◽  
Author(s):  
Tao Wang ◽  
Yanbin Gao ◽  
Xiaolei Wang ◽  
Yimin Shi ◽  
Jiayi Xu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Injury ◽  
Calpain 10

scholarly journals PTPN2 improved renal injury and fibrosis by suppressing STAT‐induced inflammation in early diabetic nephropathy

2019 ◽  
Vol 23 (6) ◽  
pp. 4179-4195 ◽  
Author(s):  
Ya Li ◽  
Huimin Zhou ◽  
Yulin Li ◽  
Lu Han ◽  
Ming Song ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Injury ◽  
Early Diabetic Nephropathy

scholarly journals Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xuehai Chen ◽  
Jiao Luo ◽  
Minmin Wu ◽  
Zhuo Pan ◽  
Yue Xie ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Islet Transplantation ◽  
Renal Injury ◽  
Microvascular Disease ◽  
Renal Tissue ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
Tubular Injury ◽  
Clinical Progression ◽  
Renal Tubular

Diabetic nephropathy (DN) is a serious microvascular complication of diabetes. Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. PTX3 is the only long pentraxin that can be detected in renal tissue. In this study, we investigated the expression of PTX3 when early DN was reversed after islet transplantation.Methods. Diabetes was induced in rats by injecting streptozotocin (STZ). Twelve weeks later, the diabetic rats were divided into 2 groups: the islet transplantation group (IT) and the diabetic nephropathy group (DN). Renal injury, renal function, and the expression of PTX3 in the plasma and the kidneys were assessed with urinalysis, immunohistochemical staining, and Western blot, respectively.Results. The expression of PTX3 in the kidney was significantly decreased in the DN group but increased in the IT group because of the reversal of DN.Conclusions. Our data showed that the level of PTX3 in renal tissue is closely related to renal injury in DN. This may be used to quantify the extent of renal injury in DN, provide a potential early indicator of renal tubular injury in early DN patients, and assess DN clinical progression.

scholarly journals Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Montserrat Romero ◽  
Arantxa Ortega ◽  
Nuria Olea ◽  
María Isabel Arenas ◽  
Adriana Izquierdo ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Parathyroid Hormone ◽  
Renal Injury ◽  
Renal Diseases ◽  
Protective Effects ◽  
Ang Ii ◽  
Related Protein ◽  
Renal Hypertrophy ◽  
Glomerular Diseases ◽  
Parathyroid Hormone Related Protein

Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1R) are extensively expressed in the kidney, where they are able to modulate renal function. Renal PTHrP is known to be overexpressed in acute renal injury. Recently, we hypothesized that PTHrP involvement in the mechanisms of renal injury might not be limited to conditions with predominant damage of the renal tubulointerstitium and might be extended to glomerular diseases, such as diabetic nephropathy (DN). In experimental DN, the overexpression of both PTHrP and the PTH1R contributes to the development of renal hypertrophy as well as proteinuria. More recent data have shown, for the first time, that PTHrP is upregulated in the kidney from patients with DN. Collectively, animal and human studies have shown that PTHrP acts as an important mediator of diabetic renal cell hypertrophy by a mechanism which involves the modulation of cell cycle regulatory proteins and TGF-β1. Furthermore, angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be responsible for PTHrP upregulation in these conditions. These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.

scholarly journals NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy

Diabetes ◽  
2017 ◽  
Vol 66 (10) ◽  
pp. 2691-2703 ◽  
Author(s):  
Jay C. Jha ◽  
Claudine Banal ◽  
Jun Okabe ◽  
Stephen P. Gray ◽  
Thushan Hettige ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nadph Oxidase ◽  
Renal Injury
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