scholarly journals PTPN2 improved renal injury and fibrosis by suppressing STAT‐induced inflammation in early diabetic nephropathy

2019 ◽  
Vol 23 (6) ◽  
pp. 4179-4195 ◽  
Author(s):  
Ya Li ◽  
Huimin Zhou ◽  
Yulin Li ◽  
Lu Han ◽  
Ming Song ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Injury ◽  
Early Diabetic Nephropathy

scholarly journals ASSESSMENT OF NEPHRIN AND PODOCIN LEVELS IN THE URINE OF PATIENTS WITH DIABETES MELLITUS

2017 ◽  
Vol 21 (2) ◽  
pp. 33-40
Author(s):  
I. N. Bobkova ◽  
A. A. Shchukina ◽  
M. V. Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Arterial Hypertension ◽  
Healthy Subjects ◽  
Early Diagnostics ◽  
Urinary Levels ◽  
Patients With Diabetes ◽  
Early Diabetic Nephropathy

THE AIM:to assess excretion value of podocytes injury biomarkers in urine and to clarify their significance for early diabetic nephropathy (DN) diagnostics in diabetes mellitus (DM) patients with different severity of albuminuria (AU)/proteinuria(PU).PATIENTS AND METHODS.74 DM pts were studied, including 30 with type1 DM (T1DM) and 44 pts with type2 DM (T2DM). They were divided into three groups: 41 pts with AU <30 mg/gCr (A1), 13 pts with AU 30-300 mg/gCr (A2), 20 pts with PU (A3). CKD S1 was revealed in 41pts, CKD S2 – in 25 pts, CKD S3 – in 8 pts. Arterial hypertension was observed in 52 pts of 74(70%), mainly in T2DM. 10 healthy subjects were studied as control. Urinary levels of nephrin and podocin (an important slit diaphragm proteins) were measured by ELISA.RESULTS.Nephrinuria (NU) >5,84ng/ml/g, which not detecting in controls, was revealed in 63% of A1 pts, in 77% – in A2, in 80% – in A3. Podocinuria (PdU)>1,73ng/ml/g was revealed in 78% of A1 pts, in 54% of A2 and in 83% – A3. NU in pts with PU was significantly higher than in AU<30 mg/g. PDU in groups with different AU/PU was equally high and has no differ between DM types. Direct correlation was obtained between NU and AU (R=0,947 p<0,05). NU and PdU in T1DM correlated directly with serum creatinine (R=0,489 p<0,05 and R=0,468 p<0,05) and indirectly with GFR (R=-0,461 p<0,05 and R=-0,36 р<0,05). In DM duration less than 5 years NU directly correlated with НbА1с level, in T2DM – indirectly with systolic blood pressure.CONCLUSON. Nephrin and podocin levels can be useful for early diagnostics and monitoring of DN. 

scholarly journals Efficacy and safety of astragalus injection combined with Western medicine in the treatment of early diabetic nephropathy

Medicine ◽  
2021 ◽  
Vol 100 (12) ◽  
pp. e25096
Author(s):  
Guojing Li ◽  
Bichen Ai ◽  
Weihua Zhang ◽  
Xingzhong Feng ◽  
Min Jiang
Keyword(s):  
Diabetic Nephropathy ◽  
Western Medicine ◽  
Efficacy And Safety ◽  
Early Diabetic Nephropathy

scholarly journals Efficacy and safety of Ginkgo biloba for patients with early diabetic nephropathy

Medicine ◽  
2020 ◽  
Vol 99 (35) ◽  
pp. e21959
Author(s):  
Hongyun Wang ◽  
Meilin Yuan ◽  
Xinrong Zou
Keyword(s):  
Diabetic Nephropathy ◽  
Ginkgo Biloba ◽  
Efficacy And Safety ◽  
Early Diabetic Nephropathy
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