scholarly journals In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid [Retraction]

2021 ◽  
Vol Volume 15 ◽  
pp. 5133-5134
Author(s):  
Yun-Hong Wang ◽  
Tong Qu ◽  
Xue-Lian Wang ◽  
Rong-Ping Yang
Keyword(s):  
Sustained Release ◽  
Salvianolic Acid ◽  
Preparation And Evaluation

scholarly journals In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid

2021 ◽  
Vol Volume 15 ◽  
pp. 1623-1631
Author(s):  
Yun-Hong Wang ◽  
Tong Qu ◽  
Xue-Lian Wang ◽  
Rong-Ping Yang
Keyword(s):  
Sustained Release ◽  
Salvianolic Acid ◽  
Preparation And Evaluation

scholarly journals Preparation and evaluation of sustained-release azithromycin tablets in vitro and in vivo

2014 ◽  
Vol 9 (3) ◽  
pp. 155-161 ◽  
Author(s):  
Le Sun ◽  
Weixiang Zhang ◽  
Xiaohong Liu ◽  
Jin Sun
Keyword(s):  
Sustained Release ◽  
Preparation And Evaluation

scholarly journals Preparation and evaluation of a stable and sustained release of lansoprazole-loaded poly(d,l-lactide-co-glycolide) polymeric nanoparticles

2019 ◽  
Vol 39 (9) ◽  
pp. 822-829 ◽  
Author(s):  
Bader B. Alsulays ◽  
Md. Khalid Anwer ◽  
Mohammed F. Aldawsari ◽  
Alhussain Aodah ◽  
Elsadig Adam ◽  
...  
Keyword(s):  
Sustained Release ◽  
Magnesium Oxide ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Plga Nanoparticles ◽  
Base Peak ◽  
Solvent Evaporation Method ◽  
Physicochemical Stability ◽  
Preparation And Evaluation

Abstract The aim of the study was to prepare lansoprazole (LNS)-loaded poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles in order to improve the physicochemical stability associated with LNS. We synthesized LNS-loaded PLGA nanoparticles in the presence of magnesium oxide as alkalizer to improve the release of LNS and stability against photodegradation. The LNS-encapsulated PLGA nanoparticles were developed by the nanoprecipitation/solvent evaporation method, resulting in a particle size of 246.7 ± 3.4 nm, polydispersity index (PDI) of 0.126, percent drug entrapment (PDE) of 82.85 ± 4.5%, percent drug loading (PDL) of 3.54 ± 0.34%, and pH of 8.10 ± 0.56. The developed nanoparticles were further evaluated for in vitro release and resistance to photodegradation by NMR spectroscopy and LC-MS. The sustained release of the drug was confirmed after the encapsulation of LNS in the PLGA matrix. The protection of LNS in the PLGA matrix against photodegradation was confirmed by NMR and LC-MS studies. The LC-MS of UV-exposed samples of pure LNS and LNS-loaded PLGA nanoparticles at 254 nm showed the same (M + 1) peak at 370 m/e, and the base peak at 369 m/e accounted for the unchanged structure of LNS inside PLGA nanoparticles. Overall, it was proved that PLGA nanoparticles in the presence of magnesium oxide are an efficient carrier to deliver and protect LNS from physicochemical instability.

scholarly journals Preparation and evaluation of tolmetin sodium conventional and sustained-release suppositories

2002 ◽  
Vol 70 (1) ◽  
pp. 77-86
Author(s):  
Baloǧlu B. ◽  
Kirkaǧaçhoǧlu O.
Keyword(s):  
Polyethylene Glycol ◽  
Sustained Release ◽  
In Vitro Release ◽  
Water Soluble ◽  
Order Kinetic ◽  
Polyethylene Glycol 400 ◽  
Suppository Base ◽  
Soluble Base ◽  
Preparation And Evaluation

Conventional suppositories of tolmetin sodium were prepared by using two different types of Witepsol as an oily base and two different ratios of polyethylene glycol 400: polyethylene glycol 4000 as an water-soluble base. In addition, sustained- release suppositories were prepared by adding Eudragit L-100 ta the suppositories. The effects of the suppository base and the ratios of the polyethylene glycol 400: polyethylene glycols 4000 on the in vitro release characteristics were investigated. The release rate of tolmetin sodium from the conventional suppositories prepared with polyethylene glycol was slower than the other suppositories prepared with Witepsol. All of the suppositories with Eudragit L-100 showed slow-release profiles and the drug release rates clearly depended on the Eudragit L-100 content. When dissolution results were evaluated kinetically, zero order kinetic was observed with the sustained- release suppositories of tolmetin sodium prepared with polyethyleneglycol 400: polyethyleneglycol 4000 by adding Eudragit L-100.

scholarly journals Preparation and evaluation of novel galantamine hydrobromide sustained-release capsule

2016 ◽  
Vol 11 ◽  
pp. S82-S91 ◽  
Author(s):  
Shuoye Yang
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
In Vitro Study ◽  
Release Process ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Promising Alternative ◽  
Release Studies ◽  
Preparation And Evaluation

In present study, a novel galantamine hydrobromide sustained-release capsule was prepared with the extrusion-spheronization method and the optimized preparative formulation. The release studies were performed using marketed capsules (Razadyne ER) as a reference and data were analyzed in terms of cumulative release amounts as a function of time. Furthermore, fiber-optic real time detection was adopted to monitor the release process. Results demonstrated that our developed formulation had superior properties, worked better as sustained-release carriers and lasted longer time to release compared with the marketed product. The in vitro release characteristics of different batches of preparations were quite similar with each other, the total release proportions of galantamine hydrobromide from sustained-release capsules reached higher than 90% within 12 hours. Similar factors f2 of two preparations were all higher than 50, the release profile of drugs from capsules fitted to Higuchi model with the equation of Q% = 0.2681t1/2 + 0.0684 (r = 0.9966). Pharmacokinetics profile and parameters in beagle dogs after oral administration also revealed the superior release performances of new capsules being consistent with the in vitro study. The developed sustained-release formulation may be a promising alternative dosage form for treatment of related diseases. 

Effects of salvianolic acid and notoginseng triterpenes on angiogenesis in EA-hy926 cells in vitro

2014 ◽  
Vol 11 (3) ◽  
pp. 254-257 ◽  
Author(s):  
Hai-Bo SHI ◽  
Jian-Dong CHEN ◽  
Xiao-Hu CHEN ◽  
Yun HE ◽  
Zhi-Jian YANG
Keyword(s):  
Salvianolic Acid
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