scholarly journals Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer

2021 ◽  
Vol Volume 15 ◽  
pp. 3071-3093
Author(s):  
Ahmed R Gardouh ◽  
Ahmed SG Srag El-Din ◽  
Mohamed SH Salem ◽  
Yasser Moustafa ◽  
Shadeed Gad
Keyword(s):  
Pancreatic Cancer ◽  
Oral Bioavailability ◽  
Proliferative Activity ◽  
Starch Nanoparticles ◽  
Thienopyrimidine Derivative

scholarly journals Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 12992-13004 ◽  
Author(s):  
Chloe Goldsmith ◽  
Quan Vuong ◽  
Elham Sadeqzadeh ◽  
Costas Stathopoulos ◽  
Paul Roach ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Olea Europaea ◽  
Proliferative Activity ◽  
Leaf Extracts ◽  
Olea Europaea L ◽  
Pancreatic Cancer Cells ◽  
Olea Europaéa

scholarly journals Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions

1999 ◽  
Vol 19 (3-4) ◽  
pp. 175-185 ◽  
Author(s):  
Romana Tomaszewska ◽  
Krzysztof Okoń ◽  
Krystyna Nowak ◽  
Jerzy Stachura
Keyword(s):  
Pancreatic Cancer ◽  
Proliferative Activity ◽  
Diagnostic Value ◽  
Pancreatic Disease ◽  
Proliferation Index ◽  
Low Grade ◽  
Cell Nuclei ◽  
Ki 67 ◽  
Single Feature ◽  
Papillary Hyperplasia

The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. In the present paper we studied the proliferative activity (Ki‐67 index) in pancreatic intraepithelial proliferative lesions and its correlation with geometric features of cell nuclei as signs of increasing dysplasia. The studies were carried out in a group of 35 patients operated on for pancreatic cancer, chronic pancreatitis and other conditions not associated with the pancreas. We used immunohistochemical methods and basic morphometric parameters. The results of our studies indicate that the cell proliferative activity depends both on the type of epithelial proliferation and underlying pancreatic disease. The values of Ki‐67 index are significantly different in low‐grade proliferation (flat and papillary hyperplasia) and high‐grade proliferation (atypical papillary hyperplasia and carcinomain situ). A set of karyometric features correlates with Ki‐67 index but there is no single feature which would have a diagnostic value.

Effect of lenalidomide on the antiproliferative effect of gemcitabine against pancreatic tumor cells and on immune-mediated pancreatic cancer cell death

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e14635-e14635
Author(s):  
L. Wu ◽  
W. Liu ◽  
C. Galustian ◽  
P. Schafer ◽  
A. G. Dalgleish ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Tumor Cells ◽  
Solid Tumor ◽  
Proliferative Activity ◽  
Pancreatic Tumor ◽  
Pancreatic Cancer Cell ◽  
Chemotherapeutic Agents ◽  
Immune Mediated

e14635 Background: Lenalidomide is an immunomodulatory and anti-angiogenic agent that has demonstrated activity against a range of hematological malignancies. Despite evidence of direct anti-proliferative activity against hematological cells in vitro, there is no evidence of single agent direct activity against solid tumor cells in vitro. To take advantage of its known immune-enhancing properties alongside direct anti-tumor agents, lenalidomide is being advanced in solid tumor indications in combination with other agents. There are few data regarding the combination of lenalidomide and standard of care chemotherapeutic agents, such as gemcitabine. Methods: Here, we assess the effects of lenalidomide alone, and in combination with gemcitabine, on pancreatic cancer cell growth and survival, and the ability of lenalidomide to enhance the ability of human PBMC to kill allogeneic pancreatic tumor cells (BxPC3, PANC-1 and MiaPaCa) in a PBMC:tumor cell co-culture model. Results: Lenalidomide alone had no effect on the proliferation of pancreatic cancer cells (BxPC-3 and Panc-1) whereas gemcitabine had moderate anti-proliferative activity. With combination therapy there was clear synergistic enhancement of anti-proliferative activity in both cell lines and additive effects were observed in a BxPC-3 xenograft mouse model of pancreatic cancer. About 20% of tumor cells were sensitive to immune-mediated cell death and, for BxPC3, this was increased significantly in the presence of lenalidomide. Lenalidomide significantly and dose-dependently enhanced immune-mediated killing (both T and NK cells are required for tumor cell killing in this model). For PANC-1 and MiaPaCa, immune-mediated killing was also increased by lenalidomide, albeit non-significantly. Conclusions: These results suggest that, in addition to anti-angiogenic and other effects within the tumor microenvironment, lenalidomide may act as an immune adjuvant to enhance the recognition and apoptosis of tumor cells by host T and NK cells. These studies support the potential utility of lenalidomide in combination with chemotherapeutic agents, gemcitabine in particular, in the treatment of patients with solid tumors including pancreatic cancer. [Table: see text]

scholarly journals Significance of proliferative activity and DNA ploidy in pancreatic cancer and chronic pancreatitis

1999 ◽  
Vol 26 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Hagen Loertzer ◽  
Raoul Hinze ◽  
Jürgen Knolle ◽  
Friedrich-Wilhelm Rath ◽  
Adrian Schmassmann
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Proliferative Activity ◽  
Dna Ploidy

Abstract 1012: Discovery and synthesis of novel autophagy inhibitors with anti-proliferative activity in lung and pancreatic cancer cells

2015 ◽  
Author(s):  
Juan Sironi ◽  
Lars Ulrik Nordstroem ◽  
Evelyn Aranda ◽  
Marina Shcherba ◽  
Roman Perez-Soler ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Proliferative Activity ◽  
Pancreatic Cancer Cells
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