scholarly journals Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 12992-13004 ◽  
Author(s):  
Chloe Goldsmith ◽  
Quan Vuong ◽  
Elham Sadeqzadeh ◽  
Costas Stathopoulos ◽  
Paul Roach ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Olea Europaea ◽  
Proliferative Activity ◽  
Leaf Extracts ◽  
Olea Europaea L ◽  
Pancreatic Cancer Cells ◽  
Olea Europaéa

Selective ultrasound-enhanced enzymatic hydrolysis of oleuropein to its aglycon in olive (Olea europaea L.) leaf extracts

2017 ◽  
Vol 220 ◽  
pp. 282-288 ◽  
Author(s):  
María del Mar Delgado-Povedano ◽  
Feliciano Priego-Capote ◽  
María Dolores Luque de Castro
Keyword(s):  
Enzymatic Hydrolysis ◽  
Olea Europaea ◽  
Leaf Extracts ◽  
Olea Europaea L ◽  
Hydrolysis Of ◽  
Olea Europaéa

scholarly journals Evaluation of Phytochemical and Antioxidant Properties of 15 Italian Olea europaea L. Cultivar Leaves

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1998 ◽  
Author(s):  
Francesca Nicolì ◽  
Carmine Negro ◽  
Marzia Vergine ◽  
Alessio Aprile ◽  
Eliana Nutricati ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Olea Europaea ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Dry Weight ◽  
Total Phenolic ◽  
Therapeutic Effects ◽  
Leaf Extracts ◽  
Olea Europaea L ◽  
Olea Europaéa

Olive leaf extracts are of special interest due to their proven therapeutic effects. However, they are still considered a by-product of the table olive and the oil industries. In order to learn possible ways of exploiting this waste for health purposes, we investigated the phytochemical profiles and antioxidant activities in the leaves of 15 Italian Olea europaea L. cultivars grown in the same pedoclimatic conditions. The phenolic profiles and amounts of their seven representative compounds were analyzed using HPLC ESI/MS-TOF. The antioxidant activities were determined using three different antioxidant assays (DPPH, ORAC, and superoxide anion scavenging assay). Wide ranges of total phenolic content (11.39–48.62 g GAE kg−1 dry weight) and antioxidant activities (DPPH values: 8.67–29.89 µmol TE mg−1 dry weight, ORAC values: 0.81–4.25 µmol TE mg−1 dry weight, superoxide anion scavenging activity values: 27.66–48.92 µmol TE mg−1 dry weight) were found in the cultivars. In particular, the cultivars Itrana, Apollo, and Maurino, showed a high amount of total phenols and antioxidant activity, and therefore represent a suitable natural source of biological compounds for use in terms of health benefits.

scholarly journals The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ling-Wei Hii ◽  
Swee-Hua Erin Lim ◽  
Chee-Onn Leong ◽  
Swee-Yee Chin ◽  
Ngai-Paing Tan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cancer Cells ◽  
Cell Lines ◽  
Statistical Significance ◽  
Ductal Adenocarcinoma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Leaf Extracts ◽  
Pancreatic Cancer Cells ◽  
Clinacanthus Nutans

Abstract Background Clinacanthus nutans extracts have been consumed by the cancer patients with the hope that the extracts can kill cancers more effectively than conventional chemotherapies. Our previous study reported its anti-inflammatory effects were caused by inhibiting Toll-like Receptor-4 (TLR-4) activation. However, we are unsure of its anticancer effect, and its interaction with existing chemotherapy. Methods We investigated the anti-proliferative efficacy of polar leaf extracts (LP), non-polar leaf extracts (LN), polar stem extract (SP) and non-polar stem extracts (SN) in human breast, colorectal, lung, endometrial, nasopharyngeal, and pancreatic cancer cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, MTT assay. The most potent extracts was tested along with gemcitabine using our established drug combination analysis. The effect of the combinatory treatment in apoptosis were quantified using enzyme-linked immunosorbent assay (ELISA), Annexin V assay, antibody array and immunoblotting. Statistical significance was analysed using one-way analysis of variance (ANOVA) and post hoc Dunnett’s test. A p-value of less than 0.05 (p < 0.05) was considered statistical significance. Results All extracts tested were not able to induce potent anti-proliferative effects. However, it was found that pancreatic ductal adenocarcinoma, PDAC (AsPC1, BxPC3 and SW1990) were the cell lines most sensitive cell lines to SN extracts. This is the first report of C. nutans SN extracts acting in synergy with gemcitabine, the first line chemotherapy for pancreatic cancer, as compared to conventional monotherapy. In the presence of SN extracts, we can reduce the dose of gemcitabine 2.38–5.28 folds but still maintain the effects of gemcitabine in PDAC. SN extracts potentiated the killing of gemcitabine in PDAC by apoptosis. Bax was upregulated while bcl-2, cIAP-2, and XIAP levels were downregulated in SW1990 and BxPC3 cells treated with gemcitabine and SN extracts. The synergism was independent of TLR-4 expression in pancreatic cancer cells. Conclusion These results provide strong evidence of C. nutans extracts being inefficacious as monotherapy for cancer. Hence, it should not be used as a total substitution for any chemotherapy agents. However, SN extracts may synergise with gemcitabine in the anti-tumor mechanism.

Antioxidant and aldose reductase inhibition activity of Ligustrum japonicum and Olea europaea L. leaf extracts

2011 ◽  
Vol 113 (7) ◽  
pp. 876-885 ◽  
Author(s):  
Vassiliki T. Papoti ◽  
Kyriaki Pegklidou ◽  
Eleftheria Perifantsi ◽  
Nikolaos Nenadis ◽  
Vassilios J. Demopoulos ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Olea Europaea ◽  
Inhibition Activity ◽  
Leaf Extracts ◽  
Aldose Reductase Inhibition ◽  
Olea Europaea L ◽  
Ligustrum Japonicum ◽  
Olea Europaéa

ANTIBACTERIAL ACTIVITY AND CHEMICAL CONSTITUTIONS OF OLEA EUROPAEA L. LEAF EXTRACTS

2010 ◽  
Vol 34 (3) ◽  
pp. 383-396 ◽  
Author(s):  
MIHRIBAN KORUKLUOGLU ◽  
YASEMIN SAHAN ◽  
AYCAN YIGIT ◽  
ELIF TUMAY OZER ◽  
SEREF GÜCER
Keyword(s):  
Antibacterial Activity ◽  
Olea Europaea ◽  
Leaf Extracts ◽  
Olea Europaea L ◽  
Olea Europaéa
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