scholarly journals A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection

2020 ◽  
Vol Volume 14 ◽  
pp. 2797-2807
Author(s):  
Neda Moazzezy ◽  
Mohammad Reza Asadi Karam ◽  
Sima Rafati ◽  
Saeid Bouzari ◽  
Mana Oloomi
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Inflammatory Cytokines ◽  
Murine Model ◽  
Synthetic Peptide ◽  
Bacterial Titer ◽  
Pro Inflammatory Cytokines

scholarly journals Impact of Host Age and Parity on Susceptibility to Severe Urinary Tract Infection in a Murine Model

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97798 ◽  
Author(s):  
Kimberly A. Kline ◽  
Drew J. Schwartz ◽  
Nicole M. Gilbert ◽  
Amanda L. Lewis
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Murine Model ◽  
Host Age

scholarly journals Struvite Urolithiasis and Chronic Urinary Tract Infection in a Murine Model of Urinary Diversion

Urology ◽  
2013 ◽  
Vol 81 (5) ◽  
pp. 943-948 ◽  
Author(s):  
Brian Becknell ◽  
Ashley R. Carpenter ◽  
Brad Bolon ◽  
John R. Asplin ◽  
Susan E. Ingraham ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Diversion ◽  
Murine Model ◽  
Chronic Urinary Tract Infection

scholarly journals Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection

2015 ◽  
Vol 73 (4) ◽  
Author(s):  
Eric L. Buckles ◽  
Courtney L. Luterbach ◽  
Xiaolin Wang ◽  
C. Virginia Lockatell ◽  
David E. Johnson ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Murine Model

scholarly journals A murine model of urinary tract infection

2009 ◽  
Vol 4 (8) ◽  
pp. 1230-1243 ◽  
Author(s):  
Chia-Suei Hung ◽  
Karen W Dodson ◽  
Scott J Hultgren
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Murine Model

scholarly journals Impact of Low-Level Resistance to Fluoroquinolones Due to qnrA1 and qnrS1 Genes or a gyrA Mutation on Ciprofloxacin Bactericidal Activity in a Murine Model of Escherichia coli Urinary Tract Infection

2009 ◽  
Vol 53 (10) ◽  
pp. 4292-4297 ◽  
Author(s):  
Nicolas Allou ◽  
Emmanuelle Cambau ◽  
Laurent Massias ◽  
Françoise Chau ◽  
Bruno Fantin
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bactericidal Activity ◽  
Murine Model ◽  
Bacterial Counts ◽  
Low Level ◽  
The Impact ◽  
Level Resistance

ABSTRACT We investigated the impact of low-level resistance to fluoroquinolones on the bactericidal activity of ciprofloxacin in a murine model of urinary tract infection. The susceptible Escherichia coli strain CFT073 (ciprofloxacin MIC [CIP MIC] of 0.008 μg/ml) was compared to its transconjugants harboring qnrA1 or qnrS1 and to an S83L gyrA mutant. The three derivatives showed similar low-level resistance to fluoroquinolones (CIP MICs, 0.25 to 0.5 μg/ml). Bactericidal activity measured in vitro after 1, 3, and 6 h of exposure to 0.5 μg/ml of ciprofloxacin was significantly lower for the derivative strains (P < 0.01). In the murine model of urinary tract infection (at least 45 mice inoculated per strain), mice were treated with a ciprofloxacin regimen of 2.5 mg/kg, given subcutaneously twice daily for 2 days. In mice infected with the susceptible strain, ciprofloxacin significantly decreased viable bacterial counts (log10 CFU/g of tissue) in the bladder (4.2 ± 0.5 versus 5.5 ± 1.3; P = 0.001) and in the kidney (3.6 ± 0.8 versus 5.0 ± 1.1; P = 0.003) compared with those of untreated mice. In contrast, no significant decrease in viable bacterial counts was observed with any of the three derivative strains. The area under the concentration-time curve from 0 to 24 h/MIC and the maximum concentration of drug in serum/MIC ratios measured in plasma were indeed equal to 827 and 147, respectively, for the parental strain, and only 12.4 to 24.8 and 2.2 to 4.4, respectively, for the derivative strains. In conclusion, low-level resistance to fluoroquinolones conferred by a qnr gene is associated with decreased bactericidal activity of ciprofloxacin, similar to that obtained with a gyrA mutation.

scholarly journals Activity of temocillin in a murine model of urinary tract infection due toEscherichia coliproducing or not producing the ESBL CTX-M-15

2015 ◽  
Vol 70 (5) ◽  
pp. 1466-1472 ◽  
Author(s):  
J. F. Soubirou ◽  
B. Rossi ◽  
C. Couffignal ◽  
E. Ruppé ◽  
F. Chau ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Murine Model

scholarly journals Characterization of theebpfmpilus-encoding operon ofEnterococcus faeciumand its role in biofilm formation and virulence in a murine model of urinary tract infection

Virulence ◽  
2010 ◽  
Vol 1 (4) ◽  
pp. 236-246 ◽  
Author(s):  
Jouko Sillanpää ◽  
Sreedhar R. Nallapareddy ◽  
Kavindra V. Singh ◽  
Vittal P. Prakash ◽  
Timothy Fothergill ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Murine Model ◽  
Biofilm Formation
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