scholarly journals Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation

2018 ◽  
Vol Volume 12 ◽  
pp. 3653-3664 ◽  
Author(s):  
Ralf Regenthal ◽  
Margarita Voskanian ◽  
Frank Baumann ◽  
Jens Teichert ◽  
Christian Brätter ◽  
...  
Keyword(s):  
Adhesive Formulation ◽  
Pharmacokinetic Evaluation

In-vitro and In-vivo Pharmacokinetic Evaluation of Guar Gum-Eudragit® S100 Based Colon-targeted Spheroids of Sulfasalazine Co-administered with Probiotics

2018 ◽  
Vol 15 (3) ◽  
pp. 367-387 ◽  
Author(s):  
Abhinav Sharma ◽  
Bimlesh Kumar ◽  
Sachin Kumar Singh ◽  
Monica Gulati ◽  
Yogyata Vaidya ◽  
...  
Keyword(s):  
Guar Gum ◽  
Pharmacokinetic Evaluation

Development, Validation and Application of HPLC Method for Metformin in Rabbit Plasma

2019 ◽  
Vol 15 (6) ◽  
pp. 574-579
Author(s):  
Muhammad Ubaid ◽  
Mahmood Ahmad ◽  
Farhan Ahmad Khan ◽  
Ghulam Murtaza
Keyword(s):  
Flow Rate ◽  
Present Method ◽  
Mobile Phase ◽  
Hplc Method ◽  
Plasma Samples ◽  
Rabbit Plasma ◽  
Uv Detector ◽  
Reverse Phase ◽  
T Values ◽  
Pharmacokinetic Evaluation

Objective:This study was aimed at conducting a pharmacokinetic evaluation of metformin in rabbit plasma samples using rapid and sensitive HPLC method and UV detection.Methods:Acetonitrile was used for protein precipitation in the preparation of plasma samples. Reverse phase chromatography technique with silica gel column (250 mm × 4.6 mm, 5 μm) at 30°was used for the separation purpose. Methanol and phosphate buffer (pH 3.2) mixture was used as a mobile phase with flow rate 0.8 ml/min. The wavelength of UV detector was adjusted at 240 nm.Results:The calibration curve was linear in a range of 0.1-1 µg/ml with R² = 0.9982. The precision (RSD, %) values were less than 2%, whereas, accuracy of method was higher than 92.37 %. The percentage recovery values ranged between 90.14 % and 94.97 %. LOD and LOQ values were 25 ng/ml and 60 ng/ml, respectively. Cmax and AUC0-t values were found to be 1154.67 ± 243.37 ng/ml and 7281.83 ± 210.84 ng/ml.h, respectively after treating rabbits with a formulation containing 250 mg metformin.Conclusion:Based on the above findings, it can be concluded that present method is simple, precise, rapid, accurate and specific and thus, can be efficiently used for the pharmacokinetic study of metformin.

Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation

2014 ◽  
Vol 116 (4) ◽  
pp. 343-348 ◽  
Author(s):  
Torben K. Nielsen ◽  
Martin Højgaard ◽  
Jon T. Andersen ◽  
Henrik E. Poulsen ◽  
Jens Lykkesfeldt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ascorbic Acid ◽  
Cancer Patients ◽  
High Dose ◽  
Dose Infusion ◽  
Pharmacokinetic Evaluation
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