Development and pharmacokinetic evaluation of once-daily sustained-released matrix capsules of nifedipine using solid dispersion technique

2013 ◽  
Vol 7 (12) ◽  
pp. 658-665
Author(s):  
Wenwu Zheng
Keyword(s):  
Solid Dispersion ◽  
Once Daily ◽  
Dispersion Technique ◽  
Pharmacokinetic Evaluation

Improvement of the diuretic effect of triamterene via solid dispersion technique with PEG 4000

1994 ◽  
Vol 19 (4) ◽  
pp. 295-302 ◽  
Author(s):  
M. J. Arias ◽  
J. M. Gines ◽  
J. R. Moyano ◽  
M. J. Perez-Barrales ◽  
M. T. Vela ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Diuretic Effect ◽  
Peg 4000 ◽  
Dispersion Technique

Improvement of dissolution rate of tacrolimus by solid dispersion technique

2013 ◽  
Vol 43 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Pranav V. Patel ◽  
Shital S. Panchal ◽  
Tejal A. Mehta
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Dispersion Technique

scholarly journals Enhancement of Solubility and Dissolution Rate of Indomethacin by Chitosan Based Solid Dispersion Technique.

2015 ◽  
Vol 5 (2) ◽  
pp. 1463-1472 ◽  
Author(s):  
Shete A.S . ◽  
Yadav V.B . ◽  
Sakhare S.S . ◽  
Patil S.B . ◽  
Sajane S.J . ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Dispersion Technique

scholarly journals A REVIEW ON DISINTEGRATION CONTROL MATRIX TABLETS

2018 ◽  
Vol 8 (5) ◽  
pp. 19-22
Author(s):  
Pralhad K. Kanke ◽  
Pankaj Sawant ◽  
Ajit Jadhav ◽  
Md. Rageeb Md. Usman
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Solid Dispersion ◽  
Gastrointestinal Transit ◽  
Matrix Tablets ◽  
Surface Erosion ◽  
Matrix Tablet ◽  
Control Matrix ◽  
Dispersion Technique ◽  
Wax Coating

A number of sustained release formulations are available in the market which successfully sustained the drug release over a prolonged period of time by different mechanisms. The new approach for sustaining the drug release is disintegration control matrix tablet which sustained the drug release up to 24hrs by controlling the disintegration rate of tablet. Disintegration control matrix tablet (DCMT) mainly forms the granules containing drug and disintegrating agent such as low substituted hydroxyl propyl cellulose by various methods such as solid dispersion technique. The sustained release of drug is maintained by increasing the wax coating or decreasing the amount of disintegrants. The release of drug from tablet is uniform throughout till all the drug releases from tablet as it involves drug release by diffusion, dissolution and surface erosion mechanism. DCMT increases the solubility of drug and improves the bioavailability without disturbing gastrointestinal transit. BCS Class II, III, IV drugs are the best candidate for DCMT formulations. Keywords: Disintegration control matrix tablet (DCMT), Wax, Disintegrating agent, Solid dispersion.

Sign in / Sign up

Export Citation Format

Share Document