scholarly journals Reduced Prescription of Baloxavir After Suspected Prevalence of a Baloxavir-Resistant Influenza Virus Strain and the Emergence of SARS-CoV-2 in a Tertiary Hospital in Japan

2020 ◽  
Vol Volume 12 ◽  
pp. 131-134
Author(s):  
Yasuhiro Kamioka ◽  
Shota Kashiwagura ◽  
Masafumi Seki
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Tertiary Hospital ◽  
Influenza Virus Strain

scholarly journals Protective Efficacy of the Conserved NP, PB1, and M1 Proteins as Immunogens in DNA- and Vaccinia Virus-Based Universal Influenza A Virus Vaccines in Mice

2015 ◽  
Vol 22 (6) ◽  
pp. 618-630 ◽  
Author(s):  
Wenling Wang ◽  
Renqing Li ◽  
Yao Deng ◽  
Ning Lu ◽  
Hong Chen ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Influenza A ◽  
Protective Efficacy ◽  
Lethal Dose ◽  
Influenza Vaccines ◽  
Strong Immune Response ◽  
Influenza Virus Strain ◽  
Vaccinia Viruses ◽  
Viral Components

ABSTRACTThe conventional hemagglutinin (HA)- and neuraminidase (NA)-based influenza vaccines need to be updated most years and are ineffective if the glycoprotein HA of the vaccine strains is a mismatch with that of the epidemic strain. Universal vaccines targeting conserved viral components might provide cross-protection and thus complement and improve conventional vaccines. In this study, we generated DNA plasmids and recombinant vaccinia viruses expressing the conserved proteins nucleoprotein (NP), polymerase basic 1 (PB1), and matrix 1 (M1) from influenza virus strain A/Beijing/30/95 (H3N2). BALB/c mice were immunized intramuscularly with a single vaccine based on NP, PB1, or M1 alone or a combination vaccine based on all three antigens and were then challenged with lethal doses of the heterologous influenza virus strain A/PR/8/34 (H1N1). Vaccines based on NP, PB1, and M1 provided complete or partial protection against challenge with 1.7 50% lethal dose (LD50) of PR8 in mice. Of the three antigens, NP-based vaccines induced protection against 5 LD50and 10 LD50and thus exhibited the greatest protective effect. Universal influenza vaccines based on the combination of NP, PB1, and M1 induced a strong immune response and thus might be an alternative approach to addressing future influenza virus pandemics.

scholarly journals Near-Complete Genome Sequence of Avian Influenza Virus Strain A/mallard/Balkhash/6304/2014 (H1N1) from Kazakhstan

2019 ◽  
Vol 8 (18) ◽  
Author(s):  
Kobey Karamendin ◽  
Aidyn Kydyrmanov ◽  
Saule Asanova ◽  
Elizaveta Khan ◽  
Klara Daulbayeva ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Virus Strain ◽  
Mallard Duck ◽  
Content Type ◽  
Influenza Virus Strain ◽  
Monitoring Study ◽  
Bird Monitoring ◽  
Eastern Kazakhstan

An avian influenza virus strain, A/mallard/Balkhash/6304/2014 (H1N1), was isolated during a wild bird monitoring study in Kazakhstan in 2014. The virus was isolated from a wild mallard duck (Anas platyrhynchos) in eastern Kazakhstan.

scholarly journals Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain

2013 ◽  
Vol 10 (1) ◽  
pp. 47 ◽  
Author(s):  
Masatoshi Okamatsu ◽  
Yoshihiro Sakoda ◽  
Takahiro Hiono ◽  
Naoki Yamamoto ◽  
Hiroshi Kida
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
Influenza Virus Strain ◽  
2009 H1n1

scholarly journals Nearly Complete Genome Sequence of Human Influenza Virus Strain A/Almaty/6327/2014 (H1N1) from Central Asia

2019 ◽  
Vol 8 (47) ◽  
Author(s):  
Kobey Karamendin ◽  
Aidyn Kydyrmanov ◽  
Saule Asanova ◽  
Elizaveta Khan ◽  
Klara Daulbayeva ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Genome Sequence ◽  
Virus Strain ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Human Population ◽  
Population Surveillance ◽  
Human Influenza ◽  
Human Influenza Virus ◽  
Influenza Virus Strain

An influenza virus strain, A/Almaty/6327/2014 (H1N1), was isolated in Almaty (in southeastern Kazakhstan) during a human population surveillance study in 2014. Here, we present the nearly complete genome sequence of this epidemic strain that was compared to the postpandemic variants of A(H1N1)pdm09.

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