GENETIC SUPPRESSION OF VIRULENCE IN THE INFLUENZA VIRUS STRAIN WS -

1958 ◽  
Vol 36 (2) ◽  
pp. 159-172 ◽  
Author(s):  
Patricia E Lind ◽  
FM Burnet
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Influenza Virus Strain ◽  
Genetic Suppression

scholarly journals Protective Efficacy of the Conserved NP, PB1, and M1 Proteins as Immunogens in DNA- and Vaccinia Virus-Based Universal Influenza A Virus Vaccines in Mice

2015 ◽  
Vol 22 (6) ◽  
pp. 618-630 ◽  
Author(s):  
Wenling Wang ◽  
Renqing Li ◽  
Yao Deng ◽  
Ning Lu ◽  
Hong Chen ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Influenza A ◽  
Protective Efficacy ◽  
Lethal Dose ◽  
Influenza Vaccines ◽  
Strong Immune Response ◽  
Influenza Virus Strain ◽  
Vaccinia Viruses ◽  
Viral Components

ABSTRACTThe conventional hemagglutinin (HA)- and neuraminidase (NA)-based influenza vaccines need to be updated most years and are ineffective if the glycoprotein HA of the vaccine strains is a mismatch with that of the epidemic strain. Universal vaccines targeting conserved viral components might provide cross-protection and thus complement and improve conventional vaccines. In this study, we generated DNA plasmids and recombinant vaccinia viruses expressing the conserved proteins nucleoprotein (NP), polymerase basic 1 (PB1), and matrix 1 (M1) from influenza virus strain A/Beijing/30/95 (H3N2). BALB/c mice were immunized intramuscularly with a single vaccine based on NP, PB1, or M1 alone or a combination vaccine based on all three antigens and were then challenged with lethal doses of the heterologous influenza virus strain A/PR/8/34 (H1N1). Vaccines based on NP, PB1, and M1 provided complete or partial protection against challenge with 1.7 50% lethal dose (LD50) of PR8 in mice. Of the three antigens, NP-based vaccines induced protection against 5 LD50and 10 LD50and thus exhibited the greatest protective effect. Universal influenza vaccines based on the combination of NP, PB1, and M1 induced a strong immune response and thus might be an alternative approach to addressing future influenza virus pandemics.

scholarly journals Near-Complete Genome Sequence of Avian Influenza Virus Strain A/mallard/Balkhash/6304/2014 (H1N1) from Kazakhstan

2019 ◽  
Vol 8 (18) ◽  
Author(s):  
Kobey Karamendin ◽  
Aidyn Kydyrmanov ◽  
Saule Asanova ◽  
Elizaveta Khan ◽  
Klara Daulbayeva ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Virus Strain ◽  
Mallard Duck ◽  
Content Type ◽  
Influenza Virus Strain ◽  
Monitoring Study ◽  
Bird Monitoring ◽  
Eastern Kazakhstan

An avian influenza virus strain, A/mallard/Balkhash/6304/2014 (H1N1), was isolated during a wild bird monitoring study in Kazakhstan in 2014. The virus was isolated from a wild mallard duck (Anas platyrhynchos) in eastern Kazakhstan.

scholarly journals Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain

2013 ◽  
Vol 10 (1) ◽  
pp. 47 ◽  
Author(s):  
Masatoshi Okamatsu ◽  
Yoshihiro Sakoda ◽  
Takahiro Hiono ◽  
Naoki Yamamoto ◽  
Hiroshi Kida
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
Influenza Virus Strain ◽  
2009 H1n1

scholarly journals Nearly Complete Genome Sequence of Human Influenza Virus Strain A/Almaty/6327/2014 (H1N1) from Central Asia

2019 ◽  
Vol 8 (47) ◽  
Author(s):  
Kobey Karamendin ◽  
Aidyn Kydyrmanov ◽  
Saule Asanova ◽  
Elizaveta Khan ◽  
Klara Daulbayeva ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Genome Sequence ◽  
Virus Strain ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Human Population ◽  
Population Surveillance ◽  
Human Influenza ◽  
Human Influenza Virus ◽  
Influenza Virus Strain

An influenza virus strain, A/Almaty/6327/2014 (H1N1), was isolated in Almaty (in southeastern Kazakhstan) during a human population surveillance study in 2014. Here, we present the nearly complete genome sequence of this epidemic strain that was compared to the postpandemic variants of A(H1N1)pdm09.

Pathogenicity for Chickens of Avian Influenza Virus Strain H9N1 Isolated from Water Coot in India

2009 ◽  
Vol 8 (3) ◽  
pp. 252-255
Author(s):  
B.P. Shankar ◽  
R.N.S. Gowda ◽  
B.H. Manjunath ◽  
B. Pattnaik ◽  
S. Nagarajan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Virus Strain ◽  
Influenza Virus Strain
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