scholarly journals The relationship between the COPD Assessment Test score and airflow limitation in Japan in patients aged over 40 years with a smoking history

2014 ◽  
pp. 1357 ◽  
Author(s):  
Paul Jones ◽  
Daisuke Yoshimoto ◽  
Yasutaka Nakano ◽  
Katsuya Onishi ◽  
Gerry Hagan
Keyword(s):  
Test Score ◽  
Airflow Limitation ◽  
Smoking History ◽  
Copd Assessment Test ◽  
The Relationship ◽  
Over 40 Years

Is COPD Assessment Test score better correlated with airflow limitation or Hyperinflation?

2021 ◽  
Author(s):  
Soumaya Khaldi ◽  
Khouloud Kchaou ◽  
Asma Chaker ◽  
Salma Mokaddem ◽  
Saloua Ben Khamsa Jameleddine
Keyword(s):  
Test Score ◽  
Airflow Limitation ◽  
Copd Assessment Test

scholarly journals Evaluation of the Persian Transcript of the COPD Assessment Test in the Measurement of COPD Health Status in Iranian COPD Patients

2015 ◽  
Vol 8 (5) ◽  
pp. 225 ◽  
Author(s):  
Alireza Azargon ◽  
Mohammadreza Gholami ◽  
Ali Farhadi ◽  
Maryam Hadi Chegni ◽  
Abolfazl Zendedel
Keyword(s):  
Disease Severity ◽  
Chronic Obstructive Lung Disease ◽  
Airway Disease ◽  
Cross Sectional Study ◽  
Airflow Limitation ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Copd Assessment Test ◽  
The Relationship ◽  
Obstruction Severity

<p><strong>AIM:</strong> Chronic obstructive pulmonary disease is a completely irreversible obstructive airway disease. The COPD assessment test (CAT) is one of the standard methods for the clinical assessment of the disease, which is translated into Persian. This study investigated the reliability of the test and its relationship with the severity of the disease.</p><p><strong>METHODS:</strong> In this cross-sectional study, 120 patients filled out the Persian transcript of the test. After two weeks, the patients filled out the CAT test again. Obstruction severity was determined for all the patients using spirometry, and the patients were categorized into four groups according to the Global Initiative for Chronic Obstructive Lung Disease criteria. The relationship between the test scores and the disease severity wan validated.</p><p><strong>RESULTS:</strong> The mean age of the patients was 51.5 years. The Cronbach's alpha coefficient of the Persian transcript of the test was 0.872 in the first time, and 0.885 in the second time. Intragroup reliability, test re-test and intragroup correlations were significant for all the questions (&lt;0.001). The relationship between the test mean score and obstruction severity was significant, and the correlation between disease categorization in accordance with obstruction severity and categorization according to the test score was significant as well.</p><p><strong>CONCLUSION:</strong> The Persian transcript of the assessment test for COPD was reliable and is directly related to the disease severity according to airflow limitation.</p>

scholarly journals Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

2021 ◽  
Vol 13 ◽  
Author(s):  
Pei-Lun Kuo ◽  
Ann Zenobia Moore ◽  
Frank R. Lin ◽  
Luigi Ferrucci
Keyword(s):  
Dna Methylation ◽  
Longitudinal Study ◽  
Smoking History ◽  
Future Research ◽  
Age Related ◽  
Epigenetic Age ◽  
Epigenetic Age Acceleration ◽  
Baltimore Longitudinal Study ◽  
Age Related Hearing Loss ◽  
The Relationship

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated diseases and mortality. However, the association between epigenetic age acceleration and hearing remains unknown. Our study aims to investigate the relationship between epigenetic age acceleration and audiometric hearing in the Baltimore Longitudinal Study of Aging (BLSA).Methods: Participants with both DNA methylation and audiometric hearing measurements were included. The main independent variables are epigenetic age acceleration measures, including intrinsic epigenetic age acceleration—“IEAA,” Hannum age acceleration—“AgeAccelerationResidualHannum,” PhenoAge acceleration—“AgeAccelPheno,” GrimAge acceleration—“AgeAccelGrim,” and methylation-based pace of aging estimation—“DunedinPoAm.” The main dependent variable is speech-frequency pure tone average. Linear regression was used to assess the association between epigenetic age acceleration and hearing.Results: Among the 236 participants (52.5% female), after adjusting for age, sex, race, time difference between measurements, cardiovascular factors, and smoking history, the effect sizes were 0.11 995% CI: (–0.00, 0.23), p = 0.054] for Hannum’s clock, 0.08 [95% CI: (–0.03, 0.19), p = 0.143] for Horvath’s clock, 0.10 [95% CI: (–0.01, 0.21), p = 0.089] for PhenoAge, 0.20 [95% CI: (0.06, 0.33), p = 0.004] for GrimAge, and 0.21 [95% CI: (0.09, 0.33), p = 0.001] for DunedinPoAm.Discussion: The present study suggests that some epigenetic age acceleration measurements are associated with hearing. Future research is needed to study the potential subclinical cardiovascular causes of hearing and to investigate the longitudinal relationship between DNA methylation and hearing.

scholarly journals COPD assessment test and severity of airflow limitation in patients with asthma, COPD, and asthma–COPD overlap syndrome

2016 ◽  
pp. 479 ◽  
Author(s):  
Kazuyoshi Kurashima ◽  
Yotaro Takaku ◽  
Chie Ohta ◽  
Noboru Takayanagi ◽  
Tsutomu Yanagisawa ◽  
...  
Keyword(s):  
Overlap Syndrome ◽  
Airflow Limitation ◽  
Copd Assessment Test

Abstract 165: Platelet Derived Growth Factor (pdgf) is Associated With Progression of Symptomatic Intracranial Large Artery Atherosclerosis

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Sang-Wuk Jeong
Keyword(s):  
Logistic Model ◽  
Matched Control ◽  
Univariate Analysis ◽  
Platelet Derived Growth Factor ◽  
Smoking History ◽  
Tnf Alpha ◽  
Large Artery ◽  
Risk Of Progression ◽  
The Relationship ◽  
Age And Sex

Background and Purpose: Studies on the molecular pathways involved in the progression of intracranial large artery atherosclerosis are rare. We aimed to study the relationship between biomarkers and the risk of progression of symptomatic intracranial large artery atherosclerosis. Methods: Of 409 patients in Trial of cilostazol in symptomatic intracranial stenosis-2 (TOSS-2) study, 52 patients showed progression of symptomatic intracranial large artery atherosclerosis on MRA after 7 months. We selected 20 patients with progression and 40 age- and sex- matched control patients. We collected blood sample initially, one month and 7 month after infarction, and multiplex analysis of biomarkers including interleukin-1,2,6,8,10, soluble CD40ligand, TNF alpha, PDGF, soluble ICAM, E-selectin and VCAM , MMP-2,3,9, SOD1,2,3 and adipokines, were performed. Results: Demographic features such as age, sex, hypertension, diabetes and smoking history were not different between both groups. On univariate analysis, 7 month PDGF-AA (3053 ± 2896 pg/ml, vs 1444±1548 pg/ml), PDGF-AB/BB (15304.0±15634 pg/ml vs 5627±8656 pg/ml) level and MPO(25.7±33.9vs 9.9±8.7ng/ml) were higher in progression group. On multivariate analysis using logistic model, 7 month PDGF AA is independent prognostic factor for progression of intracranial large artery atherosclerosis (p=0.012). Conclusion: PDGF-AB/BB level is associated with progression of symptomatic intracranial large artery atherosclerosis.

Airflow limitation as a risk factor for vascular stiffness

2020 ◽  
Vol 24 (6) ◽  
pp. 577-584
Author(s):  
S. S. Sheen ◽  
H. J. Kim ◽  
D. Singh ◽  
S. C. Hwang ◽  
K. J. Park ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Forced Expiratory Volume ◽  
Vascular Stiffness ◽  
University Hospital ◽  
Airflow Limitation ◽  
Smoking History ◽  
Chronic Obstructive ◽  
Health Examination

BACKGROUND: Cardiovascular disease is one of the main causes of mortality in patients with chronic obstructive pulmonary disease (COPD), and atherosclerosis is a cause of cardiac comorbidities in COPD. However, it is not clear whether airflow limitation is associated with atherosclerosis irrespective of smoking.OBJECTIVE: To investigate whether airflow limitation is independently associated with vascular stiffness.METHODS: We enrolled 18 893 participants (male 70.5%; mean age 47.5 ± 9.8 years; never smokers 44.2%) who underwent spirometry and brachial-ankle pulse wave velocity (baPWV) as part of a standard health examination at Ajou University Hospital, Suwon, South Korea, from January 2010 to December 2015.We defined vascular peripheral atherosclerosis as baPWV ≥ 1400 cm/s and airflow limitation as pre-bronchodilator ratio of forced expiratory volume in 1 sec (FEV1) to forced vital capacity (FVC) <70%.RESULTS: Mean baPWV was higher in subjects with airflow limitation (1477.6 ± 331.7 cm/sec, n = 638) than in those without airflow limitation (1344.1 ± 231.8 cm/sec, n = 18255, P < 0.001). In multivariate logistic regression analysis, the following were independent predictors associated with peripheral atherosclerosis (P < 0.05): age, male sex, fasting serum glucose, mean blood pressure, serum leukocyte count, serum low density lipoprotein level and FEV1.CONCLUSION: Airflow limitation was an independent predictor of vascular stiffness irrespective of smoking history, which suggests that airflow limitation is linked with atherosclerosis.

Spiritual Well-Being and Marital Adjustment

1988 ◽  
Vol 16 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Patricia D. Roth
Keyword(s):  
Religious Orientation ◽  
Marital Adjustment ◽  
Well Being ◽  
Dyadic Adjustment ◽  
Scale Scores ◽  
Spiritual Well Being ◽  
Married Individuals ◽  
Relationship Of ◽  
The Relationship ◽  
Over 40 Years

This pilot study investigated the relationship of spiritual well-being (defined here as a well-integrated internal religious orientation) to marital adjustment. The subscale dimensions of satisfaction, cohesion, consensus, and affectual expression were used as indicators of adjustment as measured by Spanier's (1976) Dyadic Adjustment Scale. These scale scores were correlated with the religious, existential, and spiritual well-being scores from Paloutzian & Ellison's (1982) Spiritual Well-Being Scale. Subjects were 147 married individuals from churches in Southern California. Responses indicated that spiritual well-being correlated significantly to marital adjustment, with significant differences for years married: Those married 10–40 years showed a higher correlation than those married over 40 years. Existential well-being scores correlated highly with marital adjustment scores at most marital stages. This provides some support for the hypothesis that lived-out spirituality is an important factor in perception of marital happiness.

scholarly journals Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD)

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 783 ◽  
Author(s):  
Ozretić ◽  
da Silva Filho ◽  
Catalano ◽  
Sokolović ◽  
Vukić-Dugac ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Minor Allele ◽  
Fine Tuning ◽  
Airflow Limitation ◽  
Smoking History ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Impact

Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by a progressive decline in lung function due to airflow limitation, mainly related to IL-1β-induced inflammation. We have hypothesized that single nucleotide polymorphisms (SNPs) in NLRP genes, coding for key regulators of IL-1β, are associated with pathogenesis and clinical phenotypes of COPD. We recruited 704 COPD individuals and 1238 healthy controls for this study. Twenty non-synonymous SNPs in 10 different NLRP genes were genotyped. Genetic associations were estimated using logistic regression, adjusting for age, gender, and smoking history. The impact of genotypes on patients’ overall survival was analyzed with the Kaplan–Meier method with the log-rank test. Serum IL-1β concentration was determined by high sensitivity assay and expression analysis was done by RT-PCR. Decreased lung function, measured by a forced expiratory volume in 1 s (FEV1% predicted), was significantly associated with the minor allele genotypes (AT + TT) of NLRP1 rs12150220 (p = 0.0002). The same rs12150220 genotypes exhibited a higher level of serum IL-1β compared to the AA genotype (p = 0.027) in COPD patients. NLRP8 rs306481 minor allele genotypes (AG + AA) were more common in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) definition of group A (p = 0.0083). Polymorphisms in NLRP1 (rs12150220; OR = 0.55, p = 0.03) and NLRP4 (rs12462372; OR = 0.36, p = 0.03) were only nominally associated with COPD risk. In conclusion, coding polymorphisms in NLRP1 rs12150220 show an association with COPD disease severity, indicating that the fine-tuning of the NLRP1 inflammasome could be important in maintaining lung tissue integrity and treating the chronic inflammation of airways.

scholarly journals Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers

2009 ◽  
Vol 107 (5) ◽  
pp. 1622-1628 ◽  
Author(s):  
A. William Sheel ◽  
Jordan A. Guenette ◽  
Ren Yuan ◽  
Lukas Holy ◽  
John R. Mayo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Tomographic Imaging ◽  
Smoking History ◽  
Men And Women ◽  
Male And Female ◽  
Computed Tomographic ◽  
Males And Females ◽  
Airway Tree ◽  
Conducting Airways ◽  
The Relationship

We sought to determine the relationship between lung size and airway size in men and women of varying stature. We also asked if men and women matched for lung size would still have differences in airway size and if so where along the pulmonary airway tree would these differences exist. We used computed tomography to measure airway luminal areas of the large and central airways. We determined airway luminal areas in men ( n = 25) and women ( n = 25) who were matched for age, body mass index, smoking history, and pulmonary function and in a separate set of men ( n = 10) and women ( n = 11) who were matched for lung size. Men had greater values for the larger airways and many of the central airways. When male and female subjects were pooled there were significant associations between lung size and airway size. Within the male and female groups the magnitudes of these associations were decreased or nonsignificant. In males and females matched for lung size women had significantly smaller airway luminal areas. The larger conducting airways in females are significantly smaller than those of males even after controlling for lung size.

COPD EXACERBATION RATE BY BASELINE COPD ASSESSMENT TEST SCORE IN THE DYNAGITO STUDY

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A1758-A1759
Author(s):  
Peter Calverley ◽  
Christine Jenkins ◽  
Jadwiga Wedzicha ◽  
Alberto de la Hoz ◽  
Florian Voß ◽  
...  
Keyword(s):  
Test Score ◽  
Copd Exacerbation ◽  
Exacerbation Rate ◽  
Copd Assessment Test
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